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Calcium Signalling (Intracellular)
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ALX-151-023 Revised 23-Nov-06
Autocamtide-2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-023-M001   1 mg 80.00 USD Add To Cart
ALX-151-023-M005   5 mg 320.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH
FORMULA: C65H118N22O20
MW: 1527.8
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Very selective substrate for Ca2+/calmodulin-dependent protein kinase II.
Product Specific Literature References
Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation: P.I. Hanson, et al.; Neuron 3, 59 (1989) Abstract
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Peptides
 
 
ALX-151-029 Revised 23-Nov-06
Autocamtide-2-Related Inhibitory Peptide
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SYNONYMS AIP
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-029-M001   1 mg 75.00 USD Add To Cart
ALX-151-029-M005   5 mg 300.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
FORMULA: C64H116N22O19
MW: 1497.8
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Highly specific and potent inhibitor of Ca2+/calmodulin-dependent protein kinase II without affecting cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and Ca2+/calmodulin-dependent protein kinase IV.
Product Specific Literature References
A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II: A. Ishida, et al.; BBRC 212, 806 (1995) Abstract
Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain: A. Ishida & H. Fujisawa; J. Biol. Chem. 270, 2163 (1995) Abstract; Full Text
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Peptides
 
 
ALX-151-030 Revised 05-Feb-08
Autocamtide-2-Related Inhibitory Peptide (Myristoylated)
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SYNONYMS AIP Myristoylated
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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ALX-151-030-MC05   0.5 mg 90.00 USD Add To Cart
Product Specification
SEQUENCE: Myr-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
FORMULA: C78H142N22O20
MW: 1708.1
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Corresponds to Prod. No. ALX-151-029 but this one is N-terminal myristoylated to increase cell permeability.
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Peptides
 
 
ALX-153-006 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase II (290-309)
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SYNONYMS CaM Kinase II (290-309)
CAMK2 (290-309)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-006-MC01   0.1 mg 40.00 USD Add To Cart
ALX-153-006-M001   1 mg 120.00 USD Add To Cart
Product Specification
SEQUENCE: H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
FORMULA: C103H185N31O24S
MW: 2273.9
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent inhibitor of Ca2+/calmodulin-dependent protein kinase II.
Product Specific Literature References
Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains: M.E. Payne, et al.; J. Biol. Chem. 263, 7190 (1988) Abstract; Full Text
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Peptides
 
 
ALX-153-008 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase IV Substrate
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SYNONYMS CaM Kinase IV Substrate
CAMK4 Substrate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-008-M001   1 mg 70.00 USD Add To Cart
ALX-153-008-M005   5 mg 290.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Ser-Asp-Gly-Gly-Val-Lys-Lys-Arg-Lys-Ser-Ser-Ser-Ser-OH
FORMULA: C58H107N21O22
MW: 1450.6
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Very selective and potent substrate for a brain-specific Ca2+/calmodulin-dependent protein kinase IV over Ca2+/calmodulin-dependent protein kinase II. This peptide corresponds to aa 345-358 of Ca2+/calmodulin-dependent protein kinase II-δ.
Product Specific Literature References
Purification and characterization of a brain-specific multifunctional calmodulin-dependent protein kinase from rat cerebellum: O. Miyano, et al.; J. Biol. Chem. 267, 1198 (1992) Abstract; Full Text
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Peptides
 
 
ALX-153-009 Revised 20-Sep-05
Ca2+/Calmodulin-dependent Protein Kinase II (281-289)
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SYNONYMS CaM Kinase II (281-289)
CAMK2 (281-289)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinases
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-009-M001   1 mg 70.00 USD Add To Cart
ALX-153-009-M005   5 mg 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-OH
FORMULA: C43H71N15O16S2
MW: 1118.3
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Amino acid sequence defining the major Ca2+-dependent autophosphorylation site of Ca2+/calmodulin-dependent protein kinase II.
Product Specific Literature References
Regulatory interactions of the calmodulin-binding, inhibitory, and autophosphorylation domains of Ca2+/calmodulin-dependent protein kinase II: R.J. Colbran, et al.; J. Biol. Chem. 263, 18145 (1988) Abstract; Full Text
Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues: M.K. Smith, et al.; J. Biol. Chem. 267, 1761 (1992) Abstract; Full Text
Ca2+/calmodulin-dependent protein kinase II is phosphorylated by protein kinase C in vitro: M.N. Waxham & J. Aronowski; Biochemistry 32, 2923 (1993) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-153-010 Revised 16-Feb-05
[Ala286]-Ca2+/Calmodulin-dependent Protein Kinase II (281-302)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-010-MC01   0.1 mg 50.00 USD Add To Cart
ALX-153-010-M001   1 mg 190.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Ala-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-OH
FORMULA: C111H191N39O29S2
MW: 2600.1
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Inhibitor of Ca2+/calmodulin-dependent protein kinase II catalytic fragment, competitive with ATP. The sequence for this product matches that of the original article describing this "CaM kinase II inhibitor" peptide.
Product Specific Literature References
Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues: M.K. Smith, et al.; J. Biol. Chem. 267, 1761 (1992) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-153-018 Revised 16-Feb-05
[Ala288]-Ca2+/Calmodulin-dependent Protein Kinase II (281-289)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinases
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ALX-153-018-M005   5 mg 60.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-His-Arg-Gln-Glu-Thr-Val-Ala-Cys-OH
FORMULA: C42H71N15O14S2
MW: 1074.3
PURITY: ≥97%
APPEARANCE: Lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-157-003 Revised 03-Mar-05
Galanin (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Galanin & Galanin Receptor/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-157-003-PC05   0.5 mg* 190.00 USD Add To Cart
ALX-157-003-P001   1 mg* 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser-OH
FORMULA: C139H210N42O43
MW: 3157.4
CAS NUMBER: 119418-04-1
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Galanin: profile of a new neuropeptide: L.W. Haynes; TIPS 7, 214 (1986), (Review)
Galanin - a newly isolated biologically active neuropeptide: A. Rökaeus; Trends Neurosci. 10, 158 (1987)
Galanin and the endocrine pancreas: B. Ahren, et al.; FEBS Lett. 229, 233 (1988) Abstract
Galanin. A selective inhibitor of insulin secretion?: J. Dupré; Pancreas 3, 119 (1988) Abstract
Co-existence of galanin and acetylcholine: is galanin involved in memory processed and dementia?: J.N. Crawley & G.L. Wenk; TINS 12, 278 (1989) Abstract
Inhibitory action of galanin on gastric acid secretion in pentobarbital-anesthetized rats: W.J. Rossowski & D.H. Coy; Life Sci. 44, 1807 (1989) Abstract
Galanin in the porcine pancreas: T. Messell, et al.; Regul. Pept. 28, 161 (1990) Abstract
Human galanin: primary structure and identification of two molecular forms: M. Bersani, et al.; FEBS Lett. 283, 189 (1991) Abstract
Isolation and primary structure of pituitary human galanin, a 30- residue nonamidated neuropeptide: W.E. Schmidt, et al.; PNAS 88, 11435 (1991) Abstract
Human galanin: molecular cloning reveals a unique structure: H.F. Evans & J. Shine; Endocrinology 129, 1682 (1991) Abstract
Further Categories Containing This Product:
Neuropeptides & Receptors Other Products • Ca2+ Modulators • Peptides
 
 
ALX-157-004 Revised 29-Nov-02
Galanin (pig)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Galanin & Galanin Receptor/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-157-004-PC05   0.5 mg* 180.00 USD Add To Cart
ALX-157-004-P001   1 mg* 290.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-His-Asp-Lys-Tyr-Gly-Leu-Ala-NH2
FORMULA: C146H213N43O40
MW: 3210.6
CAS NUMBER: 88813-36-9
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
For reviews see Galanin (human) (Prod. No. ALX-157-003).
Product Specific Literature References
Galanin - a novel biologically active peptide from porcine intestine: K. Tatemoto, et al.; FEBS Lett. 164, 124 (1983) Abstract
Further Categories Containing This Product:
Ca2+ Modulators • Peptides
 
 
ALX-162-006 Revised 07-Apr-08
Melittin (natural)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-162-006-M001   1 mg 40.00 USD Add To Cart
ALX-162-006-M005   5 mg 160.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
FORMULA: C131H229N39O31
MW: 2846.5
CAS NUMBER: 37231-28-0
MERCK INDEX: 14: 5824
RTECS: OS3960000
SOURCE/HOST: Isolated from bee venom.
PURITY: ≥85% (HPLC)
APPEARANCE: Off-white to faint tan powder.
PURITY DETAIL: Phospholipase A2 impurity: <5 units per mg solid.
SOLUBILITY: Soluble in PBS (5mg/ml) or water (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic. Protect from light.
HAZARD: HARMFUL.
Product Description
Causes disruption of normal cellular activity and cell lysis. Binds calmodulin in a calcium-dependent manner. Activates phospholipase A2 (PLA2) and inhibits protein kinase C (PKC) by binding to the catalytic domain in a Mg-ATP sensitive manner. Antirheumatic.
Product Specific Literature References
Rapid purification of calmodulin and S-100 protein by affinity chromatography with melittin immobilized to sepharose: R.L. Kincaid & C.C. Coulson; BBRC 133, 256 (1985) Abstract
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C: J. Baudier, et al.; Biochemistry 26, 2886 (1987) Abstract
Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin: J.E. Fletcher & M.S. Jiang; Toxicon. 31, 669 (1993) Abstract
Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivo: C.L. Ownby, et al.; Toxicon. 35, 67 (1997) Abstract
Melittin binds to secretory phospholipase A2 and inhibits its enzymatic activity: S.S. Saini, et al.; BBRC 238, 436 (1997) Abstract
Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells: S.T. Chu, et al.; Life Sci. 80, 364 (2007) Abstract