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Receptors
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ALX-101-010 Revised 11-Sep-07
L-Aspartic acid
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SYNONYMS H-L-Asp-OH
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY L-Amino Acids
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ALX-101-010-G001   1 g 12.00 USD Add To Cart
Product Specification
FORMULA: C4H7NO4
MW: 133.1
CAS NUMBER: 56-84-8
MERCK INDEX: 14: 840
RTECS: CI9098500
PURITY: ≥99.5%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Excitatory Amino Acids • NMDA Receptors/Related Products
 
 
ALX-101-011 Revised 22-Nov-06
D-Aspartic acid
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SYNONYMS H-D-Asp-OH
PRODUCT LINE Combinatorial Chemistry
PRODUCT CATEGORY D-Amino Acids
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ALX-101-011-G001   1 g 12.00 USD Add To Cart
Product Specification
FORMULA: C4H7NO4
MW: 133.1
CAS NUMBER: 1783-96-6
MERCK INDEX: 14: 840
RTECS: CI9097500
PURITY: ≥99%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Excitatory Amino Acids • NMDA Receptors/Related Products
 
 
ALX-105-009 Revised 06-Jun-06
N-Methyl-D-aspartic acid
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SYNONYMS NMDA
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-009-M010   10 mg 23.00 USD Add To Cart
ALX-105-009-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C5H9NO4
MW: 147.1
CAS NUMBER: 6384-92-5
MERCK INDEX: 14: 6662
RTECS: CI9457000
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base; slightly soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Selective ionotropic NMDA receptor agonist.
Product Specific Literature References
Excitatory amino acid transmitters: J.C. Watkins & R.H. Evans; Ann. Rev. Pharmacol. Toxicol. 21, 165 (1981), (Review) Abstract
NMDA receptors and ligands in the vertebrate CNS: T.W. Stone & N.R. Burton; Progr. Neurobiol. 30, 333 (1988), (Review) Abstract
Further Categories Containing This Product:
Special Amino Acids • NMDA Receptors/Related Products
 
 
ALX-106-023 Revised 13-Dec-02
5-Hydroxy-L-tryptophan
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors/Related Products
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ALX-106-023-M500   500 mg 20.00 USD Add To Cart
Product Specification
FORMULA: C11H12N2O3
MW: 220.2
CAS NUMBER: 56-69-9
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Serotonin precursor.
Further Categories Containing This Product:
Special Amino Acids • Glutamate Receptors (Metabotropic)/Related Products
 
 
ALX-106-024 Revised 06-Jun-06
O-Phospho-L-serine
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SYNONYMS L-Phosphoserine
L-Serine-O-phosphate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors/Related Products
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ALX-106-024-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C3H8NO6P
MW: 185.1
CAS NUMBER: 407-41-0
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Store tightly sealed. Use fresh solutions.

Product Description
L-AP4 agonist. Competitive NMDA antagonist. Has affinity for type IV, but not type I, metabotropic glutamate receptor.
Product Specific Literature References
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes: W.E. Klunk, et al.; J. Neurochem. 56, 1997 (1991) Abstract
Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor: C. Thomsen & P.D. Suzdak; Neuroreport 4, 1099 (1993) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis: K. Borodezt & S.R. D'Mello; J. Neurosci. Res. 53, 531 (1998) Abstract
Further Categories Containing This Product:
Special Amino Acids • Glutamate Receptors (Metabotropic)/Related Products
 
 
ALX-106-028 Revised 03-Apr-08
D-Cycloserine
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SYNONYMS R(+)-4-Amino-3-isoxazolidinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-106-028-M050   50 mg 20.00 USD Add To Cart
ALX-106-028-M250   250 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C3H6N2O2
MW: 102.1
CAS NUMBER: 68-41-7
RTECS: NY2975000
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Hygroscopic.

Product Description
Excitatory amino acid. Partial agonist at the glycine modulatory site of the NMDA receptor.
Further Categories Containing This Product:
Excitatory Amino Acids • Special Amino Acids • NMDA Receptors/Related Products
 
 
ALX-106-037 Revised 09-Oct-07
L-Cycloserine
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SYNONYMS S(-)-4-Amino-3-isoxazolidinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-106-037-M025   25 mg 50.00 USD Add To Cart
ALX-106-037-M100   100 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C3H6N2O2
MW: 102.1
CAS NUMBER: 339-72-0; 4834-58-6
MERCK INDEX: 14: 2751
RTECS: NY2976000
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Excitatory amino acid. Inhibitor of ketosphinganine synthase (serine-palmitoyl-CoA transferase, EC 2.3.1.50), leading to blockade of sphingosine biosynthesis. Partial agonist at the glycine modulatory site of the NMDA receptor.
Product Specific Literature References
Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo: K.S. Sundaram & M. Lev; J. Neurochem. 42, 577 (1984) Abstract
Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine: R.D. Williams, et al.; J. Lipid Res. 28, 1478 (1987) Abstract; Full Text
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes: G.B. Watson, et al.; Brain Res. 510, 158 (1990) Abstract
D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain: I.P. Chessell, et al.; Brain Res. 565, 345 (1991) Abstract
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor: G.S. Shukla, et al.; Biochim. Biophys. Acta 1083, 101 (1991) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids • NMDA Receptors/Related Products • Special Amino Acids
 
 
ALX-151-020 Revised 10-Feb-05
N-Acetyl-Asp-Glu-OH
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SYNONYMS α-NAAG
Spaglumic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic)/Related Products
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ALX-151-020-M010   10 mg 35.00 USD Add To Cart
ALX-151-020-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C11H16N2O8
MW: 304.3
CAS NUMBER: 3106-85-2
PURITY: ≥98%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.
Product Specific Literature References
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain glutamate receptor: R. Zaczek, et al.; PNAS 80, 1116 (1983) Abstract
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors: K.J. Koller & J.T. Coyle; Eur. J. Pharmacol. 98, 193 (1984) Abstract
The neurobiology of N-acetylaspartylglutamate: R.D. Blakely & J.T. Coyle; Int. Rev. Neurobiol. 30, 39 (1988) Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997) Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997) Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997) Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997) Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997) Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997) Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998) Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998) Abstract
A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999) Abstract
Further Categories Containing This Product:
NMDA Receptors/Related Products • NAALADase/Related Products • Peptides
 
 
ALX-152-001 Revised 12-Sep-05
Big Endothelin-1 (1-38) (human)
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SYNONYMS Big ET-1 (1-38) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors/Related Products
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ALX-152-001-PC01   0.1 mg* 100.00 USD Add To Cart
ALX-152-001-PC05   0.5 mg* 400.00 USD Add To Cart
ALX-152-001-P001   1 mg* 650.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C189H282N48O56S5
MW: 4283.0
CAS NUMBER: 121014-53-7
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98% (HPLC)
SOLUBILITY: Soluble in water; also soluble in 0.5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988) Abstract
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo: T. Kashiwabara, et al.; FEBS Lett. 247, 73 (1989) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-002 Revised 26-Nov-04
Big Endothelin-1 (1-39) (pig)
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SYNONYMS Big ET-1 (1-39) (pig)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors/Related Products
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ALX-152-002-PC01   0.1 mg* 140.00 USD Add To Cart
ALX-152-002-PC05   0.5 mg* 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Ile-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C193H289N49O58S5
MW: 4384.1
CAS NUMBER: 121014-54-8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988) Abstract
A novel potent vasoconstrictor peptide produced by vascular endothelial cells [see comments]: M. Yanagisawa, et al.; Nature 332, 411 (1988) Abstract
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo: T. Kashiwabara, et al.; FEBS Lett. 247, 73 (1989) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-003 Revised 26-Nov-04
Big Endothelin-1 (1-39) (rat)
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SYNONYMS Big ET-1 (1-39) (rat)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors/Related Products
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Product Numbers: Format: Size: