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Geranyl-related Reagents
You are here: Product Lines > Signal Transduction > G-Protein Coupled Receptor Signalling > Geranyl-related Reagents
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ALX-290-007 Revised 02-Jun-08
N-Acetyl-S-geranyl-L-cysteine
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SYNONYMS AGC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Geranyl-related Reagents
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ALX-290-007-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C15H25NO3S
MW: 299.4
PURITY: ≥98% (TLC)
APPEARANCE: Clear to pale yellow viscous oil.
SOLUBILITY: > 25mg/ml soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solutions may be stored at -20 °C for up to 3 months. Product is not sterile.

Product Description
Negative control for AFC (Prod. No. ALX-290-001) and AGGC (Prod. No. ALX-290-008). Has a closely similar structure to these two compounds but lacks their biological activity.
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ALX-290-008 Revised 13-Jul-06
N-Acetyl-S-geranylgeranyl-L-cysteine
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SYNONYMS AGGC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Geranyl-related Reagents
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ALX-290-008-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C25H41NO3S
MW: 435.7
CAS NUMBER: 139332-94-8
PURITY: ≥98%
APPEARANCE: Viscous yellow oil.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Specifically blocks methyl esterification of geranylgeranylated proteins such as Rab proteins. Blocks receptor-mediated signal transduction in human neutrophils (IC50=4µM). Induces insulin release from HIT-T15 cells by mimicking the action of Rab3A. Inhibits β2-integrin-induced actin polymerization (IC50~45nM) in neutrophils.
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ALX-290-006 Revised 25-Jun-08
Geranylgeranylpyrophosphate . triammonium salt
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SYNONYMS 3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl pyrophosphate . 3NH3
GGPP . 3NH3
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Geranyl-related Reagents
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ALX-290-006-C200   200 µg 60.00 USD Add To Cart
Product Specification
FORMULA: C20H36O7P2 . 3NH3
MW: 450.5 . 51.1
CAS NUMBER: 6699-20-3
CONCENTRATION: 1mg/ml
PURITY: ≥98%
FORMULATION: Liquid. In 70% ethanol in 0.25M NH4HCO3.
SOLUBILITY: Soluble in water; also soluble in methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL. FLAMMABLE

Product Description
Geranylgeranyl donor utilized by geranylgeranyltransferase for isoprenylation of target proteins.
Product Specific Literature References
Effects of tautomycin, a protein phosphatase inhibitor, on recycling of mammalian cell surface molecules: T. Kurisaki, et al.; J. Antibiot. 45, 252 (1992) Abstract
Steady-state kinetic mechanism of Ras farnesyl:protein transferase: D.L. Pompliano, et al.; Biochemistry 31, 3800 (1992) Abstract
Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme: Y. Reiss, et al.; J. Biol. Chem. 267, 6403 (1992) Abstract; Full Text
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys: M.C. Seabra, et al.; J. Biol. Chem 267, 14497 (1992) Abstract; Full Text
 
 
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