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ALX-380-274
Revised 21-May-08
Erythromycin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Inflammation Research
Ordering Information
Product Numbers:
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ALX-380-274-G005
5 g
40.00 USD
Product Specification
FORMULA:
C
37
H
67
NO
13
MW:
733.9
CAS NUMBER:
114-07-8
MERCK INDEX:
14:
3681
RTECS:
KF4375000
SOURCE/HOST:
Isolated from
Streptomyces erythreus
.
PURITY:
≥85% (Assay on dry basis)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (50mg/ml), 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL.
Product Description
Macrolide antibiotic. Inhibits protein synthesis (elongation) at the transpeptidation step. Binds to the 23S RNA of the 50S ribosomal subunit. Effective against Gram-negative and Gram-positive bacteria.
Product Specific Literature References
Inducible erythromycin resistance in bacteria:
B. Weisblum; Br. Med. Bull.
40
, 47 (1984)
Abstract
Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells:
Y. Aoki & P.N. Kao; Antimicrob. Agents Chemother.
43
, 2678 (1999)
Abstract
;
Full Text
Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban:
J.Q. Tran, et al.; J. Clin. Pharmacol.
39
, 513 (1999)
Abstract
Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism:
T. Tokairin, et al.; Br. J. Clin. Pharmacol.
60
, 172 (2005)
Abstract
;
Full Text
Related Products
ALX-380-264
EM574
Further Categories Containing This Product:
NF-kB Pathway Inhibitors
•
Anti-inflammatory Agents Other Products
•
Translation Inhibitors
ALX-155-005
Revised 04-Feb-05
ET-Receptor Antagonist [BE-18257A]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-155-005-PC05
0.5 mg*
75.00 USD
ALX-155-005-P001
1 mg*
125.00 USD
Product Specification
SEQUENCE:
cyclo(D-Glu-Ala-D-Val-Leu-D-Trp)
FORMULA:
C
30
H
42
N
6
O
7
MW:
598.7
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥96%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Weak and non-selective endothelin antagonist.
Product Specific Literature References
Endothelin-binding inhibitors, BE-18257A and BE-18257B. I. Taxonomy, fermentation, isolation and characterization:
K. Kojiri, et al.; J. Antibiot. (Tokyo)
44
, 1342 (1991)
Abstract
Endothelin-binding inhibitors, BE-18257A and BE-18257B II. Structure determination:
S. Nakajima, et al.; J. Antibiot. (Tokyo)
44
, 1348 (1991)
Abstract
An endothelin receptor (ETA) antagonist isolated from Streptomyces misakiensis:
M. Ihara, et al.; BBRC
178
, 132 (1991)
Abstract
WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities:
S. Miyata, et al.; J. Antibiot. (Tokyo)
45
, 74 (1992)
Abstract
WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. III. Structures of WS-7338 A, B, C and D and total synthesis of WS-7338 B:
S. Miyata, et al.; J. Antibiot. (Tokyo)
45
, 788 (1992)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-008
Revised 04-Dec-06
ET-Receptor Antagonist [PD 142,893]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-155-008-PC05
0.5 mg*
60.00 USD
ALX-155-008-P001
1 mg*
100.00 USD
Product Specification
SEQUENCE:
Ac-D-Dip-Leu-Asp-Ile-Ile-Trp-OH (D-Dip = D-3,3-Diphenylalanine; Lit. THL
33
, 3293 (1992))
FORMULA:
C
50
H
65
N
7
O
10
MW:
924.1
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in a mixture of 10% acetonitrile and 90% water or in phosphate buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Non-selective antagonist of endothelin-1 with high affinity for both the ET
A
and ET
B
receptor subtypes.
Product Specific Literature References
Design of a functional hexapeptide antagonist of endothelin:
W.L. Cody, et al.; J. Med. Chem.
35
, 3301 (1992)
Abstract
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists:
A.M. Doherty, et al.; J. Med. Chem.
36
, 2585 (1993)
Abstract
Endothelin: progress in pharmacology and physiology:
W.G. Haynes, et al.; TIPS
14
, 225 (1993), (Review)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-016
Revised 03-Mar-05
ET-Receptor Antagonist [PD 145,065]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-155-016-PC05
0.5 mg*
235.00 USD
ALX-155-016-P001
1 mg*
400.00 USD
Product Specification
SEQUENCE:
Ac-D-Bhg-Leu-Asp-Ile-Ile-Trp-OH (D-Bhg = D-5
H
-Dibenzo[a,d]cycloheptene-5-acetic acid)
FORMULA:
C
52
H
67
N
7
O
10
MW:
950.1
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent ligand for both the ET
A
and ET
B
receptor subtypes.
Product Specific Literature References
W.L. Cody, et al.; in: 'Peptides 1992: Proceedings of the 22nd European Peptide Symposium' (C.H. Schneider & A.N. Eberle, eds.), ESCOM 687 (1993)
Further Categories Containing This Product:
Peptides
ALX-155-009
Revised 04-Feb-05
ETA-Receptor Antagonist [BE-18257B]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-155-009-PC05
0.5 mg*
85.00 USD
ALX-155-009-P001
1 mg*
140.00 USD
Product Specification
SEQUENCE:
cyclo(D-Glu-Ala-allo-D-Ile-Leu-D-Trp)
FORMULA:
C
31
H
44
N
6
O
7
MW:
612.3
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥96%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Weak but highly selective ET
A
antagonist.
Product Specific Literature References
An endothelin receptor (ETA) antagonist isolated from Streptomyces misakiensis:
M. Ihara, et al.; BBRC
178
, 132 (1991)
Abstract
Endothelin-binding inhibitors, BE-18257A and BE-18257B. I. Taxonomy, fermentation, isolation and characterization:
K. Kojiri, et al.; J. Antibiot. (Tokyo)
44
, 1342 (1991)
Abstract
Endothelin-binding inhibitors, BE-18257A and BE-18257B II. Structure determination:
S. Nakajima, et al.; J. Antibiot. (Tokyo)
44
, 1348 (1991)
Abstract
WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities:
S. Miyata, et al.; J. Antibiot. (Tokyo)
45
, 74 (1992)
Abstract
WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. III. Structures of WS-7338 A, B, C and D and total synthesis of WS-7338 B:
S. Miyata, et al.; J. Antibiot. (Tokyo)
45
, 788 (1992)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-004
Revised 11-Mar-05
ETA-Receptor Antagonist [BQ-123] . sodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-155-004-P001
1 mg*
95.00 USD
ALX-155-004-P005
5 mg*
380.00 USD
Product Specification
SEQUENCE:
cyclo(D-Asp-Pro-D-Val-Leu-D-Trp . Na)
FORMULA:
C
31
H
42
N
6
O
7
. Na
MW:
633.7
CAS NUMBER:
136553-81-6
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥96%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 3 years after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
Product Description
Highly potent and selective ET
A
antagonist.
Product Specific Literature References
Identification of a domain of ETA receptor required for ligand binding
:
M. Adachi, et al.; FEBS Lett.
311
, 179 (1992)
Abstract
Conformational study of cyclo[D-Trp-D-Asp-Pro-D-Val-Leu], an endothelin- A receptor-selective antagonist:
R.A. Atkinson & J.T. Pelton; FEBS Lett.
296
, 1 (1992)
Abstract
A novel ETA antagonist (BQ-123) inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis in rat vascular smooth muscle cells:
S. Eguchi, et al.; FEBS Lett.
302
, 243 (1992)
Abstract
Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor:
M. Ihara, et al.; Life Sci.
50
, 247 (1992)
Abstract
Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications:
K. Ishikawa, et al.; J. Med. Chem.
35
, 2139 (1992)
Abstract
Endothelin: progress in pharmacology and physiology:
W.G. Haynes, et al.; TIPS
14
, 225 (1993), (Review)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-011
Revised 04-Feb-05
ETA-Receptor Antagonist [BQ-610]
SYNONYMS
BQ-610
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-155-011-P001
1 mg*
125.00 USD
ALX-155-011-P005
5 mg*
500.00 USD
Product Specification
SEQUENCE:
(Hexahydro-1
H
-azepinyl)carbonyl-Leu-D-Trp(CHO)-D-Trp-OH
FORMULA:
C
36
H
44
N
6
O
6
MW:
656.8
QUANTITY:
*Sold as net peptide weight.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
30-fold more potent ET
A
antagonist than BQ-123 in pig aortic smooth muscle membrane assay, same activity as BQ-123 when tested on pig cerebellum membrane.
Further Categories Containing This Product:
Peptides
ALX-155-017
Revised 02-Dec-04
ETA-Receptor Antagonist [FR 139317]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-155-017-PC05
0.5 mg*
180.00 USD
ALX-155-017-P001
1 mg*
340.00 USD
Product Specification
SEQUENCE:
(Hexahydro-1
H
-azepinyl)carbonyl-Leu-D-Trp(Me)-D-Ala(2-pyridyl)-OH
FORMULA:
C
32
H
43
N
6
O
5
MW:
605.8
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Selective ET
A
antagonist.
Product Specific Literature References
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists:
A.M. Doherty, et al.; J. Med. Chem.
36
, 2585 (1993)
Abstract
Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma:
B.-M. Löffler, et al.; FEBS Lett.
333
, 108 (1993)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-012
Revised 02-Dec-04
ETA-Receptor Antagonist [JKC-301]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-155-012-PC05
0.5 mg*
85.00 USD
ALX-155-012-P001
1 mg*
140.00 USD
Product Specification
SEQUENCE:
cyclo(D-Asp-Pro-D-Ile-Leu-D-Trp)
FORMULA:
C
32
H
44
N
6
O
7
MW:
624.7
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥96%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Very potent ET
A
antagonist.
Product Specific Literature References
Lippton et al. ; American Heart Association, 66th Scientific Sessions, Georgia (World Congress, Nov. 8-11, 1993)
66
, 8 (1993)
The endothelin receptor profile in L6 myotubes:
Z. Fekete, et al.; Pharmacol. Exp. Ther.
275
, 215 (1995)
Abstract
Characterization of [125I]-endothelin-1 and [125I]-BQ3020 binding to rat cerebellar endothelin receptors:
P.S. Widdowson & C.N. Kirk; Br. J. Pharmacol.
118
, 2126 (1996)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-013
Revised 02-Dec-04
ETA-Receptor Antagonist [JKC-302]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-155-013-PC05
0.5 mg*
85.00 USD
ALX-155-013-P001
1 mg*
140.00 USD
Product Specification
SEQUENCE:
cyclo(D-Ser-Pro-D-Val-Leu-D-Trp)
FORMULA:
C
30
H
42
N
6
O
6
MW:
582.7
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥96%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Very potent ET
A
antagonist.
Product Specific Literature References
Lippton et al.; American Heart Association, 66th Scientific Sessions, Georgia (World Congress, Nov. 8-11, 1993)
66
, 8 (1993)
Further Categories Containing This Product:
Peptides
ALX-155-020
Revised 17-Mar-08
ETB-Receptor Antagonist . sodium salt
SYNONYMS
BQ-788 . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-155-020-MC05
0.5 mg
133.00 USD
ALX-155-020-M001
1 mg
185.00 USD
