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Ion Channels & Transporters/Related Products
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ALX-630-069 Revised 28-Jan-08
Chlorotoxin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-069-C500   500 µg 1'200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-NH2
(Disulfide bonds between Cys2-Cys19, Cys5-Cys28, Cys16-Cys33and Cys20-Cys35)
FORMULA: C158H249N52O48S11
MW: 3995.8
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Lyophilized.
RECONSTITUTION: Reconstitute with distilled water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C.
Product Description
Potent neurotoxin. Small conductance Cl- channel blocker. Highly specific marker for glioma cells and tumors of neuroectodermal origin. Inhibits the activity of matrix metalloproteinase-2 (MMP-2).
Product Specific Literature References
Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion: J.A. DeBin, et al.; Am. J. Physiol. 264, C361 (1993) Abstract
NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels: G. Lippens, et al.; Biochemistry 34, 13 (1995) Abstract
Use of chlorotoxin for targeting of primary brain tumors
:
L. Soroceanu, et al.; Cancer Res. 58, 4871 (1998) Abstract
Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin: S.A. Lyons, et al.; Glia 39, 162 (2002) Abstract
Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2: J. Deshane, et al.; J. Biol. Chem. 278, 4135 (2003) Abstract
Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601): A. N. Mamelak & D. B. Jacoby; Expert Opin. Drug Deliv. 4, 175 (2007), (Review) Abstract
Further Categories Containing This Product:
Cl- Channels
 
 
ALX-350-283 Revised 11-Jun-07
Cinobufagin
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SYNONYMS 5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate
14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-283-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C26H34O6
MW: 442.6
CAS NUMBER: 470-37-1
PURITY: ≥99%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Specific Na+/K+-ATPase inhibitor. About as active as ouabain (Prod. No. ALX-350-066).
Product Specific Literature References
Metabolism and pharmacokinetics of cinobufagin: S. Toma, et al.; Xenobiotica 17, 1195 (1987) Abstract
Specific 12 beta-hydroxylation of cinobufagin by filamentous fungi: M. Ye, et al.; Appl. Environ. Microbiol. 70, 3521 (2004) Abstract
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005) Abstract
 
 
ALX-350-284 Revised 11-Jun-07
Cinobufotalin
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SYNONYMS 14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
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ALX-350-284-M005   5 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C26H34O7
MW: 458.6
CAS NUMBER: 1108-68-5
MERCK INDEX: 14: 2307
PURITY: ≥99%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Specific Na+/K+-ATPase inhibitor. Less active than ouabain (Prod. No. ALX-350-066).
Product Specific Literature References
Actions of bufalin and cinobufotalin, two bufadienolides respectively more active and less active than ouabain, on ouabain binding and 86Rb uptake by human erythrocytes: A.A. Brownlee, et al.; Clin. Sci. (Lond.) 78, 169 (1990) Abstract
Neutralization of cardiac toxins oleandrin, oleandrigenin, bufalin, and cinobufotalin by digibind: monitoring the effect by measuring free digitoxin concentrations: A. Dasgupta & L. Emerson ; Life Sci. 63, 781 (1998) Abstract
Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography: Z. Wang, et al.; Biomed. Chromatogr. 18, 318 (2004) Abstract
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005) Abstract
Further Categories Containing This Product:
Na+/K+-ATPase/Related ProductsNatural Products - Immunomodulators
 
 
ALX-550-242 Revised 23-Jul-04
Clofilium . tosylate
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SYNONYMS 4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium . tosylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Blockers & Inhibitors
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ALX-550-242-M025   25 mg 40.00 USD Add To Cart
ALX-550-242-M100   100 mg 120.00 USD Add To Cart
ALX-550-242-M250   250 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C21H37ClN . C7H7O3S
MW: 339.0 . 171.2
CAS NUMBER: 92953-10-1
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
K+ channel blocker. Antiarrhytmic. Cardiac depressant.
Product Specific Literature References
The differential response of normal and ischaemic Purkinje fibres to clofilium, d-sotalol and bretylium: W.B. Gough & N. el-Sherif; Cardiovasc. Res. 23, 554 (1989) Abstract
Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked: J.P. Arena & R.S. Kass; Mol. Pharmacol. 34, 60 (1988) Abstract
 
 
ALX-550-042 Revised 04-Jun-08
CNQX
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SYNONYMS 6-Cyano-7-nitroquinoxaline-2,3-dione
FG-9065
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-042-M005   5 mg 43.00 USD Add To Cart
ALX-550-042-M010   10 mg 70.00 USD Add To Cart
ALX-550-042-M025   25 mg 155.00 USD Add To Cart
ALX-550-042-M050   50 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C9H4N4O4
MW: 232.2
CAS NUMBER: 115066-14-3
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in DMSO (10mg/ml) or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions are stable for several months when stored at -20°C.
HANDLING: Protect from light.

Product Description
Potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. For the more soluble form see CNQX . disodium salt (Prod. No. ALX-550-283).
Product Specific Literature References
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science, 241, 701 (1988) Abstract
Differential effects of the excitatory amino acid antagonists, 6-cyano- 7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4- yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice: L. Turski, et al.; Neurosci. Lett. 113, 66 (1990) Abstract
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ALX-550-283 Revised 11-Jan-05
CNQX . disodium salt
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SYNONYMS 6-Cyano-7-nitroquinoxaline-2,3-dione . 2Na
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors/Related Products
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ALX-550-283-M005   5 mg 55.00 USD Add To Cart
ALX-550-283-M010   10 mg 100.00 USD Add To Cart
ALX-550-283-M025   25 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C9H2N4O4 . 2Na
MW: 230.2 . 46.0
PURITY: 98%
APPEARANCE: Dark purple solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Water soluble, potent competitive kainate/quisqualate (non-NMDA) receptor antagonist. More soluble form of CNQX (Prod. No. ALX-550-042).
Product Specific Literature References
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science 241, 701 (1988) Abstract
Differential effects of the excitatory amino acid antagonists, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice: L. Turski, et al.; Neurosci. Lett. 113, 66 (1990) Abstract
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ALX-380-034 Revised 30-Jul-08
Concanamycin A
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SYNONYMS Folimycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-034-C025   25 µg 55.00 USD Add To Cart
ALX-380-034-C100   100 µg 180.00 USD Add To Cart
ALX-380-034-M001   1 mg 750.00 USD Add To Cart
Product Specification
FORMULA: C46H75NO14
MW: 866.1
CAS NUMBER: 80890-47-7
RTECS: CB9732000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥96% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol, DMSO or acetonitrile; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Antibiotic. More potent and specific H+-ATPase inhibitor than bafilomycin A1 (Prod. No. ALX-380-030). Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Exhibits cytotoxic effects in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production.
Product Specific Literature References
Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 37, 1333 (1984) Abstract
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells: E.J. Bowman, et al.; PNAS 85, 7972 (1988) Abstract
Structure and function of vacuolar class of ATP-driven proton pumps: M. Forgac; Physiol. Rev. 69, 765 (1989) Abstract
Intravesicular acidification correlates with binding of ADP- ribosylation factor to microsomal membranes: S. Zeuzem, et al.; PNAS 89, 6619 (1992) Abstract
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993) Abstract
Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus: M. Muroi, et al.; Cell Struct. Funct. 18, 139 (1993) Abstract
Folimycin (concanamycin A), an inhibitor of V-type H(+)-ATPase, blocks cell-surface expression of virus-envelope glycoproteins: M. Muroi, et al.; BBRC 193, 999 (1993) Abstract
Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993) Abstract
Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells: M. Yilla, et al.; J. Biol. Chem. 268, 19092 (1993) Abstract; Full Text
Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death: T. Nishihara, et al.; BBRC 212, 255 (1995) Abstract
Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells: F.J. Sharom, et al.; Biochem. J. 308 (Pt2), 381 (1995) Abstract
Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c: M. Huss, et al.; J. Biol. Chem. 277, 40544 (2002) Abstract
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449: S.F. Haydock, et al.; Microbiology 151, 3161 (2005) Abstract; Full Text
Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells: J. Hong, et al.; J. Pharmacol. Exp. Ther. 319, 672 (2006) Abstract
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ALX-380-098 Revised 03-Apr-08
Concanamycin B
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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ALX-380-098-C100   100 µg 180.00 USD Add To Cart
ALX-380-098-C500   500 µg 540.00 USD Add To Cart
Product Specification
FORMULA: C45H73NO14
MW: 852.1
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥96%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in chloroform, methanol, acetonitrile or DMSO. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Antibiotic. Exhibits similar activity as concanamycin A (Prod. No. ALX-380-034) and C (Prod. No. ALX-380-099). Specific inhibitor of vacuolar-type H+-ATPase. Suppresses bone resorption in vitro. Inhibits proliferation of mouse splenic lymphocytes. Shows antifungal and larvicidal properties.
Product Specific Literature References
Structures of concanamycins B and C: H. Kinashi, et al.; J. Antibiot. 35, 1618 (1982) Abstract
Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 37, 1333 (1984) Abstract
Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells: M. Yilla, et al.; J. Biol. Chem. 268, 19092 (1993) Abstract
Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface: K. Ito, et al.; J. Antibiot. 48, 488 (1995) Abstract
Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells: F.J. Sharom, et al.; Biochem. J. 308 (Pt2), 381 (1995) Abstract
Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro: J.T. Woo, et al.; Biol. Pharm. Bull. 19, 297 (1996) Abstract
In vivo rapid reduction of alloantigen-activated CD8+ mature cytotoxic T cells by inhibitors of acidification of intracellular organelles, prodigiosin 25-C and concanamycin B: M. H. Lee, et al.; Immunology 99, 243 (2000) Abstract
Further Categories Containing This Product:
Antibiotics - AntifungalH+-ATPase/Related Products
 
 
ALX-380-099 Revised 03-Apr-08
Concanamycin C
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-099-C100   100 µg 30.00 USD Add To Cart
ALX-380-099-C500   500 µg 90.00 USD Add To Cart
Product Specification
FORMULA: C45H74O13
MW: 823.1
CAS NUMBER: 81552-34-3
RTECS: GK6887000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥96%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in chloroform, methanol, acetonitrile or DMSO. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC.