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G-Protein Coupled Receptor Signalling
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ALX-270-242 Revised 21-Feb-08
CP 55,940
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SYNONYMS (-)-cis-3-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cannabinoid Receptor Agonists & Antagonists / Related Products
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ALX-270-242-M005   5 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C24H40O3
MW: 376.6
CAS NUMBER: 83002-04-4
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: 30mg/ml soluble in DMSO, dimethyl formamide or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Cannabinoid receptor (CB) agonist which is considerably more potent than Δ9-THC in both behavioural tests and receptor binding assays. Displays high and about equal affinity for both CB1 (Ki=0.6-5.0nM) and CB2 (Ki=0.7-2.6nM) receptors.
Product Specific Literature References
Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats: J.L. Wiley, et al.; Neuropharmacology 34, 669 (1995) Abstract
Comparative receptor binding analyses of cannabinoid agonists and antagonists: B.F. Thomas, et al.; J. Pharmacol. Exp. Ther. 285, 285 (1998) Abstract
The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells: Y. Waksman, et al.; J. Pharmacol. Exp. Ther. 288, 1357 (1999) Abstract
 
 
ALX-550-120 Revised 26-May-03
(S)-4C-PG
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SYNONYMS (S)-4-Carboxyphenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-120-M001   1 mg 40.00 USD Add To Cart
ALX-550-120-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C9H9NO4
MW: 195.2
CAS NUMBER: 134052-73-6
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Competitve group I mGluR antagonist, with selectivity for mGlu1 over mGlu5 receptor.
Product Specific Literature References
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine: S.A. Eaton, et al.; Eur. J. Pharmacol. 244, 195 (1993) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999) Abstract
 
 
ALX-550-325 Revised 26-May-03
(RS)-CPPG
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SYNONYMS (RS)-α-Cyclopropyl-4-phosphonophenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-325-M001   1 mg 35.00 USD Add To Cart
ALX-550-325-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C11H14NO5P
MW: 271.2
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Most potent group II/III mGluR antagonist, with approx. 20-fold selectivity for group III over group II.
Product Specific Literature References
The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist: N.J. Toms, et al.; Br. J. Pharmacol. 119, 851 (1996) Abstract
Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord: D.E. Jane, et al.; Neuropharmacology 35, 1029 (1996) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999) Abstract
 
 
ALX-201-388 Revised 18-Mar-08
CX3CL1, Soluble  (human) (recombinant)
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SYNONYMS Fractalkine, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CX3C Chemokines & Receptors / Related Products
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ALX-201-388-C010   10 µg 170.00 USD Add To Cart
ALX-201-388-C050   50 µg 590.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and extracellular domain of human CX3CL1 (fractalkine) (aa 1-339) is fused at the C-terminus to a FLAG®-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
BIOLOGICAL ACTIVITY: Chemotaxis effect of soluble recombinant human CX3CL1 (fractalkine) in THP-1 cells (see Figure 2).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P78423: Fractalkine (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-550-314 Revised 03-Feb-05
N-Cyclobutanecarbonyl-2-phenyltryptamine
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SYNONYMS N-[2-(2-Phenylindol-3-yl)ethyl] cyclobutanecarboxyamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
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ALX-550-314-M001   1 mg 60.00 USD Add To Cart
ALX-550-314-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C21H22N2O
MW: 318.4
PURITY: ≥98%
APPEARANCE: Oil.
SOLUBILITY: Soluble in chloroform or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Melatonin receptor antagonist. More potent than Luzindole (Prod. No. ALX-550-184) in the Xenopus melanophore assay.
Product Specific Literature References
Radioligand binding affinity and biological activity of the enantiomers of a chiral melatonin analogue: D. Sugden, et al.; Eur. J. Pharmacol. 287, 239 (1995) Abstract
Mapping the melatonin receptor. 3. Design and synthesis of melatonin agonists and antagonists derived from 2-phenyltryptamines: P.J. Garratt, et al.; J. Med. Chem. 38, 1132 (1995) Abstract
Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles: D.J. Davies, et al.; J. Med. Chem. 41, 451 (1998) Abstract
 
 
ALX-550-269 Revised 27-Oct-06
8-Cyclopentyl-1,3-dipropylxanthine
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SYNONYMS DPCPX
PD 116,948
1,3-Dipropyl-8-cyclopentylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
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ALX-550-269-M010   10 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C16H24N4O2
MW: 304.4
CAS NUMBER: 102146-07-6
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow.
SOLUBILITY: Soluble in 100% ethanol or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Potent and very selective A1 adenosine receptor antagonist, both in vitro and in vivo.
Product Specific Literature References
1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) inhibition of [3H]N- ethylcarboxamidoadenosine (NECA) binding allows the visualization of putative non-A1 adenosine receptors: K.S. Lee & M. Reddington; Brain Res. 368, 394 (1986) Abstract
Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3- dipropylxanthine to rat brain membranes: R.F. Bruns, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 335, 59 (1987) Abstract
PD 116,948, a highly selective A1 adenosine receptor antagonist: S.J. Haleen, et al.; Life Sci. 40, 555 (1987) Abstract
Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations: H. von der Leyen, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 204 (1989) Abstract
Characterization of the adenosine receptors mediating hypothermia in the conscious mouse: Anderson, et al.; Br. J. Pharmacol. 113, 1386 (1994) Abstract
 
 
ALX-260-021 Revised 17-Sep-02
H-Cys-4-Abz-Met-OH
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Farnesylation / Isoprenylation Reagents
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ALX-260-021-M001   1 mg 40.00 USD Add To Cart
ALX-260-021-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C15H21N3O4S2
MW: 371.5
PURITY: ≥92%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent inhibitor of Ras farnesyltransferase.
Product Specific Literature References
Inhibitors of Ras Farnesyltransferase as Novel Antitumor Agents: A.D. Hamilton & S.M. Sebti; Drug News Perspect. 8, 138 (1995)
 
 
ALX-550-046 Revised 14-May-03
4-DAMP methiodide
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SYNONYMS 4-Diphenylacetoxy-N-methylpiperidine methiodide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Receptors (Muscarinic) / Related Products
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ALX-550-046-M005   5 mg 20.00 USD Add To Cart
ALX-550-046-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C21H26NO2I
MW: 451.4
CAS NUMBER: 1952-15-4
PURITY: ≥99.5%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
M3 muscarinic receptor antagonist.
Product Specific Literature References
A further search for selective antagonists at M2-muscarinic receptors: R.B. Barlow & M.K. Shepherd; Br. J. Pharmacol. 89, 837 (1986) Abstract
 
 
ALX-620-064 Revised 17-Dec-04
Dansyl-NECA
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SYNONYMS 1-Deoxy-1-[6-[[6-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]hexyl]amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
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ALX-620-064-MC05   0.5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C30H40N8O6S
MW: 640.8
CAS NUMBER: 219982-12-4
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Fluorescent ligand for adenosine receptors with a marked selectivity for the A1 receptor subtype. Has been successfully applied in fluorescence microscopy assays.
Product Specific Literature References
Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives: M. Macchia, et al.; Bioorg. Med. Chem. Lett. 8, 3223 (1998) Abstract
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
ALX-550-334 Revised 28-Jan-05
DCG IV
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SYNONYMS (2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-334-M001   1 mg 50.00 USD Add To Cart
ALX-550-334-M005   5 mg 150.00 USD Add To Cart
ALX-550-334-M010   10 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C7H9NO6
MW: 203.2
CAS NUMBER: 147782-19-2
PURITY: ≥96%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Highly potent group II mGluR agonist. Presynaptic depressant.
Product Specific Literature References
A potent metabotropic glutamate receptor agonist: electrophysiological actions of a conformationally restricted glutamate analogue in the rat spinal cord and Xenopus oocytes: M. Ishida, et al.; Brain Res. 537, 311 (1990) Abstract
Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells: Y. Hayashi, et al.; Br. J. Pharmacol. 107, 539 (1992) Abstract
A new metabotropic glutamate receptor agonist: developmental change of its sensitivity to receptors in the newborn rat spinal cord: M. Ishida, et al.; Neurosci. Lett. 160, 156 (1993) Abstract
A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord: M. Ishida, et al.; Br. J. Pharmacol. 109, 1169 (1993) Abstract
Synthesis of L-2-(2,3-dicarboxycyclopropyl)-glycines. Novel conformationally restricted glutamate analogues: Y. Ohfune, et al.; Bioorg. Med. Chem. Lett. 3, 15 (1993)
Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons: V.W. Wilsch, et al.; Eur. J. Pharmacol. 262, 287 (1994) Abstract
DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus: N.A. Breakwell, et al.; Eur. J. Pharmacol. 322, 173 (1997) Abstract
Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat: M. Miyamoto, et al.; Neuroscience 77, 131 (1997) Abstract
DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice: Y. Uyama, et al.; Brain Res. 752, 327 (1997) Abstract
Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV): P.J. Attwell, et al.; Brain Res. 805, 138 (1998) Abstract
Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes: I. Brabet, et al.; Neuropharmacology 37, 1043 (1998) Abstract
Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV: J. Kilbride, et al.; Eur. J. Pharmacol. 356, 149 (1998) Abstract
Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists: R. Mistry, et al.; Br. J. Pharmacol. 123, 581 (1998) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-152-031 Revised 24-Nov-06
(Des-Arg1)-Bradykinin
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SYNONYMS Bradykinin (2-9)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-031-M001   1 mg 15.00 USD Add To Cart