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Inositols & Inositolphosphates / Related Products
You are here: Product Lines > Signal Transduction > PI(3)K-Akt-mTOR Pathway > Inositols & Inositolphosphates / Related Products
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ALX-307-001 Revised 18-Feb-08
L-Quebrachitol
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SYNONYMS 1L-2-O-Methyl-chiro-inositol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-307-001-G001   1 g 40.00 USD Add To Cart
Product Specification
FORMULA: C7H14O6
MW: 194.2
CAS NUMBER: 642-38-6
SOURCE/HOST: Isolated from rubber tree.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Key starting material for the synthesis of optically active inositol phosphates.
Product Specific Literature References
Synthesis of 1D-3-deoxy-, 1D-2,3-dideoxy-, and 1D-2,3,6-trideoxy-myo-inositol 1,4,5-trisphosphate from quebrachitol, their binding affinities, and calcium release activity: A.P. Kozikowski, et al.; JACS 115, 4429 (1993)
Synthesis and Biological Activity of the D-3-Deoxy-3-fluoro and D-3-Chloro-3-deoxy Analogs of Phosphatidylinositol: A.P. Kozikowski, et al.; J. Org. Chem. 59, 963 (1994)
Quebrachitol: A Versatile Building Block in the Construction of Naturally
Occurring Bioactive Materials: J.J. Kiddle; Chem. Rev. 95, 2189 (1995), (Review) Abstract
A versatile approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from L-(-)-quebrachitol: L. Qiao, et al.; Org. Lett. 2, 115 (2000) Abstract
Further Categories Containing This Product:
Chiral Compounds (Organic) • Chemical Synthesis - Reagents & Intermediates • Inositols & Inositolphosphates / Related Products
 
 
ALX-307-002 Revised 24-Feb-05
1-D-3-Deoxy-phosphatidylinositol
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SYNONYMS DPI
3-Deoxy-D-myo-inositol 1-[(R)-2,3-bis(hexa-
decanoyloxy)propyl hydrogenphosphate]
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
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ALX-307-002-C100   100 µg 30.00 USD Add To Cart
ALX-307-002-M001   1 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C41H79O12P
MW: 795.0
PURITY: ≥98%
APPEARANCE: Off-white amorphous solid.
SOLUBILITY: Solube in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Antimetabolite of phosphatidylinositol-3-phosphate. Inhibitor of cancer cell colony formation.
Product Specific Literature References
Synthesis and biology of 1D-3-deoxyphosphatidylinositol: a putative antimetabolite of phosphatidylinositol-3-phosphate and an inhibitor of cancer cell colony formation: A.P. Kozikowski, et al.; J. Med. Chem. 38, 1053 (1995) Abstract
Further Categories Containing This Product:
Chemopreventive Agents Other Products
 
 
ALX-307-003 Revised 19-Aug-08
myo-Inositol
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
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ALX-307-003-G025   25 g 18.00 USD Add To Cart
Product Specification
FORMULA: C6H12O6
MW: 180.2
CAS NUMBER: 87-89-8
MERCK INDEX: 14: 4978
RTECS: NM7520800
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water; slightly soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
IDENTITY: Identity determined by IR.

 
 
ALX-307-004 Revised 04-Apr-07
scyllo-Inositol
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SYNONYMS Scyllitol
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
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ALX-307-004-M005   5 mg 45.00 USD Add To Cart
ALX-307-004-M025   25 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C6H12O6
MW: 180.2
CAS NUMBER: 488-59-5
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Naturally occuring isomer of myo-inositol (Prod. No. ALX-307-003).
Product Specific Literature References
In vivo conversion of [3H]myoinositol to [3H]chiroinositol in rat tissues: Y. Pak, et al.; J. Biol. Chem. 267, 16904 (1992) Abstract; Full Text
Phosphoinositide metabolism in the developing conceptus. Effects of hyperglycemia and scyllo-inositol in rat embryo culture: P.J. Strieleman, et al.; Diabetes 41, 989 (1992) Abstract
 
 
ALX-307-005 Revised 21-Nov-08
D-myo-Inositol 1,3,4,5-tetrakisphosphate . tetrapotassium salt
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SYNONYMS Ins(1,3,4,5)P4 . 4K
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
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ALX-307-005-C100   100 µg 180.00 USD Add To Cart
ALX-307-005-M001   1 mg 680.00 USD Add To Cart
Product Specification
FORMULA: C6H12O18P4 . 4K
MW: 496.0 . 156.4
CAS NUMBER: 135269-51-1
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR, 31P-NMR and MS.

Product Description
Formed by phosphorylation of Ins(1,4,5)P3. Precursor of Ins(1,3,4)P3. Suggested to play a second messenger role different from that of Ins(1,4,5)P3 (Prod.No. ALX-307-006).
Product Specific Literature References
Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver: C.A. Hansen, et al.; J. Biol. Chem. 261, 8100 (1986) Abstract; Full Text
The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues: R.F. Irvine, et al.; Nature 320, 631 (1986) Abstract
Inositol polyphosphates and intracellular calcium release: S.K. Joseph & J.R. Williamson; Arch. Biochem. Biophys. 273, 1 (1989) Abstract
Inositol 1,3,4,5-tetrakisphosphate and regulation of intracellular calcium: A.L. Boynton, et al.; Biochem. Pharmacol. 40, 1933 (1990) Abstract
Agonist-induced calcium signaling is impaired in fibroblasts overproducing inositol 1,3,4,5-tetrakisphosphate: T. Balla, et al.; J. Biol. Chem. 266, 24719 (1991) Abstract; Full Text
Inositol phosphates and Ca2+ entry: toward a proliferation or a simplification?: R.F. Irvine; FASEB J. 6, 3085 (1992) Abstract
InsP3 and Ins(1,3,4,5)P4 act in synergy to stimulate influx of extracellular Ca2+ in Xenopus oocytes: S. DeLisle; Am. J. Physiol. 262, C1456 (1992) Abstract
Inositol-1,3,4,5-tetrakisphosphate induces calcium mobilization via the inositol-1,4,5-trisphosphate receptor in SH-SY5Y neuroblastoma cells: R.A. Wilcox, et al.; Mol. Pharmacol. 44, 810 (1993) Abstract
 
 
ALX-307-006 Revised 28-Nov-08
D-myo-Inositol 1,3,4-trisphosphate . hexapotassium salt
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SYNONYMS Ins(1,3,4)P3 . 6K
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
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ALX-307-006-C100   100 µg 160.00 USD Add To Cart
ALX-307-006-M001   1 mg 760.00 USD Add To Cart
Product Specification
FORMULA: C6H9O15P3 . 6K
MW: 414.1 . 234.6
CAS NUMBER: 140385-74-6
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR, 31P-NMR and MS.

Product Description
Produced upon hormonal stimulation of cells. Precursor is postulated to be Ins(1,3,4,5)P4 (Prod. No. ALX-307-005). For the enantiomer Ins(1,3,6)P3, see Prod. No. ALX-307-050. For the cell permeable AM-derivative, see Prod. No. ALX-307-045.
Product Specific Literature References
Interconversion of inositol (1,4,5)-trisphosphate to inositol (1,3,4,5)- tetrakisphosphate and (1,3,4)-trisphosphate in permeabilized adrenal glomerulosa cells is calcium-sensitive and ATP-dependent: M.F. Rossier, et al.; BBRC 139, 259 (1986) Abstract
The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate: V.S. Bansal, et al.; J. Biol. Chem. 262, 9444 (1987) Abstract; Full Text
Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism: R.C. Inhorn, et al.; PNAS 84, 2170 (1987) Abstract
Calcium modulates the generation of inositol 1,3,4-trisphosphate in human platelets by the activation of inositol 1,4,5-trisphosphate 3-kinase: J.L. Daniel, et al.; Biochem. J. 253, 789 (1988) Abstract
Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate: X. Yang, et al.; J. Biol. Chem. 274, 18973 (1999) Abstract; Full Text
 
 
ALX-307-007 Revised 28-Nov-08
D-myo-Inositol 1,4,5-trisphosphate . hexapotassium salt
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SYNONYMS Ins(1,4,5)P3 . 6K
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
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ALX-307-007-M001   1 mg 70.00 USD Add To Cart
ALX-307-007-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C6H9O15P3 . 6K
MW: 414.1 . 234.6
CAS NUMBER: 103476-24-0
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR, 31P-NMR and MS.

Product Description
Product of phosphatidylinositol phospholipid hydrolysis. Causes release of calcium from intracellular stores.
Product Specific Literature References
myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver: S.K. Joseph, et al.; J. Biol. Chem. 259, 3077 (1984) Abstract
Inositol trisphosphate and diacylglycerol: two interacting second messengers: M.J. Berridge, et al.; Annu. Rev. Biochem. 56, 159 (1987) Abstract
Inositol 1,4,5-trisphosphate-activated calcium channels: C.D. Ferris & S.H. Snyder; Annu. Rev. Physiol. 54, 469 (1992) Abstract
 
 
ALX-307-009 Revised 28-Nov-08
D-myo-Inositol 1,4,5-trisphosphate . hexasodium salt
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SYNONYMS Ins(1,4,5)P3 . 6Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
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ALX-307-009-M001   1 mg 90.00 USD Add To Cart
ALX-307-009-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C6H9O15P3 . 6Na
MW: 414.1 . 137.9
CAS NUMBER: 108340-81-4
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR, 31P-NMR and MS.

Product Description
Product of phosphatidylinositol phospholipid hydrolysis. Causes release of calcium from intracellular stores.
 
 
ALX-307-011 Revised 28-Nov-08
D-myo-Inositol 1,4,5-trisphosphate . triammonium salt
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SYNONYMS Ins(1,4,5)P3 . 3NH4
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
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ALX-307-011-M001   1 mg 90.00 USD Add To Cart
ALX-307-011-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C6H12O15P3 . 3NH4
MW: 417.1 . 54.1
CAS NUMBER: 112571-69-4
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR, 31P-NMR and MS.

Product Description
Product of phosphatidylinositol phospholipid hydrolysis. Causes release of calcium from intracellular stores.
 
 
ALX-307-013 Revised 28-Nov-08
D-myo-Inositol 1,4,5-trisphosphate . trilithium salt
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SYNONYMS Ins(1,4,5)P3 . 3Li
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
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ALX-307-013-M001   1 mg 90.00 USD Add To Cart
ALX-307-013-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C6H12O15P3 . 3Li
MW: 417.1 . 20.8
CAS NUMBER: 129828-69-91
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR, 31P-NMR and MS.

Product Description
Product of phosphatidylinositol phospholipid hydrolysis. Causes release of calcium from intracellular stores.
Product Specific Literature References
myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver: S.K. Joseph, et al.; J. Biol. Chem. 259, 3077 (1984) Abstract; Full Text
Inositol trisphosphate and diacylglycerol: two interacting second messengers: M.J. Berridge; Ann. Rev. Biochem. 56, 159 (1987) Abstract
Inositol 1,4,5-trisphosphate-activated calcium channels: C.D. Ferris & S.H. Snyder; Annu. Rev. Physiol. 54, 469 (1992) Abstract
 
 
ALX-307-018 Revised 04-Mar-05
3-Deoxy-3-bromo-D-myo-inositol 1,4,5-trisphosphate . hexasodium salt
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SYNONYMS 3-Br-Deoxy-Ins(1,4,5)P3 . 6Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Inositols & Inositolphosphates / Related Products
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