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ALX-153-064
Revised 31-Aug-07
Caveolin-1 Scaffolding Domain Peptide
SYNONYMS
Cavtratin
AP-Cav
Pen-C1-SD
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Caveolae / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-153-064-M001
1 mg
140.00 USD
ALX-153-064-M005
5 mg
560.00 USD
Product Specification
SEQUENCE:
H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH
FORMULA:
C
228
H
335
N
61
O
49
S
MW:
4746.6
APPEARANCE:
≥97% (HPLC)
SOLUBILITY:
Soluble in DMSO or acentonitrile:water (50:50).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Hygroscopic. Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HARMFUL.
Product Description
Cell permeable peptide that blocks eNOS (NOS III) activity and cellular nitric oxide (NO) release
in vitro
and reduces inflammation and tumorigenesis
in vivo
. Caveolin-1 interacts with several lipid-modified signalling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence.
Product Specific Literature References
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane:
T. Okamoto, et al.; J. Biol. Chem.
273
, 4519 (1998)
Abstract
;
Full Text
In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation:
M. Bucci, et al.; Nat. Med.
6
, 1362 (2000)
Abstract
;
Full Text
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice:
J.P. Gratton, et al.; Cancer Cell
4
, 31 (2003)
Abstract
;
Full Text
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion:
T.M. Williams, et al.; J. Biol. Chem.
279
, 51630 (2004)
Abstract
;
Full Text
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides:
P.N. Bernatchez, et al.; PNAS
102
, 761 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
NOS Regulation
•
Cancer Other Products
ALX-165-005
Revised 16-Feb-05
PDGF β-Receptor (719-723) (phosphorylated)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SH2 & SH3 Domains
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-165-005-M001
1 mg
130.00 USD
ALX-165-005-M005
5 mg
520.00 USD
Product Specification
SEQUENCE:
H-Tyr(PO
3
H
2
)-Val-Pro-Met-Leu-OH
FORMULA:
C
30
H
48
N
5
O
10
PS
MW:
701.8
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Contains the PDGF β-receptor recognition sequence which specifically interacts with the SH2 domain of PI(3)K (phosphoinositide 3-kinase). In this phosphorylated form the peptide inhibits the binding of the 85kDa subunit of PI(3)K to the PDGF β-receptor.
Product Specific Literature References
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways:
W.J. Fantl, et al.; Cell
69
, 413 (1992)
Abstract
Closing in on SH2 specificity:
R.B. Birge & H. Hanafusa; Science
262
, 1522 (1993)
Abstract
Further Categories Containing This Product:
Peptides
•
Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
ALX-165-019
Revised 24-Feb-05
PDGF Fragment (phosphorylated) (cyclic)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SH2 & SH3 Domains
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-165-019-MC01
0.1 mg
50.00 USD
ALX-165-019-M001
1 mg
250.00 USD
Product Specification
SEQUENCE:
cyclo(Gly-Tyr(PO
3
H
2
)-Val-Pro-Met-Leu)
FORMULA:
C
32
H
49
N
6
O
10
PS
MW:
740.8
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Cyclic hexapeptide inhibitor of SH2 interactions. The peptide sequence represents the autophosphorylation region around Tyr
751
of the PDGF β-receptor.
Product Specific Literature References
Synthesis of phosphonomethyl-phenylalanine and phosphotryrosine containing cyclic peptides as inhibitors of protein kinase/SN2 interactions:
M. Nomizu, et al.; Tetrahedron
50
, 2691 (1994)
Further Categories Containing This Product:
Peptides
•
Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
ALX-168-003
Revised 02-Apr-03
Tyrosine Phosphorylation Site Inhibitor
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
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ALX-168-003-M001
1 mg
60.00 USD
ALX-168-003-M005
5 mg
240.00 USD
Product Specification
SEQUENCE:
H-Gly-Ser-Phe-Leu-Val-Arg-Glu-Ser-OH
FORMULA:
C
39
H
63
N
11
O
13
MW:
894.0
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of EGF receptor binding to SH2. The peptide corresponds to a highly conserved amino acid sequence common in a variety of SH2-containing proteins. It is the minimum essential sequence for recognition of the phosphotyrosine site.
Product Specific Literature References
Highly conserved eight amino acid sequence in SH2 is important for recognition of phosphotyrosine site:
M. Hidaka, et al.; BBRC
180
, 1490 (1991)
Abstract
Further Categories Containing This Product:
Peptides
•
SH2 & SH3 Domains
ALX-210-017
Revised 12-Apr-07
Polyclonal Antibody to NALP1 (human) (CT) (Bur 242)
SYNONYMS
anti-NACHT-, LRR- and PYD-containing Protein 1 (human) (CT) PAb (Bur 242)
anti-DEFCAP (human) (CT) PAb (Bur 242)
anti-NAC (human) (CT) PAb (Bur 242)
anti-CARD7 (human) (CT) PAb (Bur 242)
anti-Caspase Recruitment Domain-containing Protein 7 (human) (CT) PAb (Bur 242)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Inflammasome
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-210-017-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing PBS and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1058-1077 (C
1058
VPSPASQGDLHTKPLGTDD
1077
) of C-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein 1).
SPECIFICITY:
Recognizes human NALP1. Does not cross-react with mouse NALP1.
APPLICATION:
Immunohistochemistry (paraffin sections)
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
POSITIVE CONTROL:
For Positive Control (Western blot) see Prod. No.
ALX-840-603
.
Product Specific Literature References
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis
:
Z.L. Chu, et al.; J. Biol. Chem.
276
, 9239 (2001)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Polyclonal Antibodies
ALX-210-018
Revised 12-Apr-07
Polyclonal Antibody to NALP1 (human) (NT) (Bur 241)
SYNONYMS
anti-NACHT-, LRR- and PYD-containing Protein 1 (human) (NT) PAb (Bur 241)
anti-DEFCAP (human) (NT) PAb (Bur 241)
anti-NAC (human) (NT) PAb (Bur 241)
anti-CARD7 (human) (NT) PAb (Bur 241)
anti-Caspase Recruitment Domain-containing Protein 7 (human) (NT) PAb (Bur 241)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Inflammasome
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-018-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing PBS and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 161-180 (P
161
SSPDHESPSQESPNAPTST
180
) of N-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein 1).
SPECIFICITY:
Recognizes human NALP1. Does not cross-react with mouse NALP1.
APPLICATION:
Immunohistochemistry (paraffin sections)
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
POSITIVE CONTROL:
For Positive Control (Western blot) see Prod. No.
ALX-840-603
.
Product Specific Literature References
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis
:
Z.L. Chu, et al.; J. Biol. Chem.
276
, 9239 (2001)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Polyclonal Antibodies
ALX-210-023
Revised 29-Jun-05
Polyclonal Antibody to TRAF1 (human) (Bur 32)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 (human) PAb (Bur 32)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
Add To Cart
ALX-210-023-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-22 (M
1
ASSSGSSPRPAPDENEFPFGC
22
) of human TRAF1 (tumor necrosis factor (TNF) receptor-associated factor 1).
SPECIFICITY:
Recognizes human TRAF1. Detects endogenous protein by IHC and WB. Detects a band of ~50-53kDa by Western blot. Does not cross-react with other members of the TRAF family.
APPLICATION:
Immunohistochemistry (paraffin sections (1:1'000))
Immunoprecipitation (1:50)
Western Blot (1:1'000))
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies
:
J.M. Zapata, et al.; J. Immunol.
165
, 5084 (2000)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-024
Revised 29-Jun-05
Polyclonal Antibody to TRAF2 (human) (Bur 34)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 2 (human) PAb (Bur 34)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-024-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing PBS and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 6-31(V
6
TPPGSLELLQPGFSKTLLGTKLEAK
31
) of human TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2).
SPECIFICITY:
Recognizes human TRAF2. Detects endogenous protein by IHC and WB. Detects a band of ~60-64kDa by Western blot. Does not cross-react with other members of the TRAF family.
APPLICATION:
Immunohistochemistry (paraffin sections (1:2'000)
Immunoprecipitation (1:50)
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies
:
J.M. Zapata, et al.; J. Immunol.
165
, 5084 (2000)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
Polyclonal Antibodies
•
Autophagy Other Products
ALX-210-025
Revised 01-Mar-07
Polyclonal Antibody to TRAF3 (human)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (human) PAb
anti-CD40BP (human) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-025-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 5-25 (K
5
KMDSPGALQTNPPLKLHTDR
25
) of human TRAF3 (tumor necrosis factor (TNF) receptor-associated factor 3).
SPECIFICITY:
Recognizes human TRAF3 and TRAF3b. Detects a band of ~64kDa by Western blot. Does not cross-react with other members of the TRAF family.
APPLICATION:
Immunohistochemistry (paraffin sections (1:500-1:1'000))
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Immunohistochemical analysis of in vivo patterns of TRAF-3 expression, a member of the TNF receptor-associated factor family
:
S. Krajewski, et al.; J. Immunol.
159
, 5841 (1997)
Abstract
Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB
:
T.L. VanArsdale, et al.; PNAS
94
, 2460 (1997)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-026
Revised 29-Jun-05
Polyclonal Antibody to TRAF4 (human)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 4 (human) PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-026-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-18 (M
1
PGFDYKFLEKPK
RRLLC
18
) of human TRAF4 (tumor necrosis factor (TNF) receptor-associated factor 4). This sequence is completely conserved in mouse TRAF4.
SPECIFICITY:
Recognizes human TRAF4.
APPLICATION:
Immunocytochemistry (1:300-1:800, transfected cells)
Immunohistochemistry (paraffin sections (1.500-1:1'000))
Immunoprecipitation
Note:
Not recommended for Western blot.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues
:
M. Krajewska, et al.; Am. J. Pathol.
152
, 1549 (1998)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-027
Revised 29-Jun-05
Polyclonal Antibody to TRAF5 (1847)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 5 PAb (1847)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
