ALEXIS Biochemicals: Siomycin

ALX-380-243

Revised 08-Apr-08

Siomycin
SYNONYMS	Mutabilycin Sporangiomycin Antibiotic 6741-21 Mutabillicin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-243-MC05		0.5 mg	390.00 USD

Product Specification

FORMULA:	C₇₁H₈₁N₁₉O₁₈S₅
MW:	1648.9
CAS NUMBER:	12656-09-6
RTECS:	VX0600000
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS4617.
PURITY:	≥95% (HPLC)
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in DMSO or dimethyl formamide; partially soluble in methanol or 100% ethanol; poorly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Macrocyclic thiazole antibiotic with potent and selective antibacterial activity. Potent inhibitor of the oncogenic transcription factor forkhead box M1 (FoxM1) that downregulates protein and mRNA levels of FoxM1. Inhibits FoxM1 induced cell growth.

Product Specific Literature References

Studies on siomycin. I. Physicochemical properties of siomycins A, B and C: M. Ebata, et al.; J. Antibiot. 22, 364 (1969)
Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1: S.K. Radhakrishnan, et al.; Cancer Res. 22, 364 (2006) Abstract; Full Text
Future roles for FoxM1 inhibitors in cancer treatments: G.R. Adami & H. Ye; Future Oncol. 3, 1 (2007) Abstract; Full Text

Further Categories Containing This Product:

Forkhead Box [FOX] Proteins / Related Products • Other Natural Products - DNA Regulation / Transcription

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