ALEXIS Biochemicals: Sirtinol

ALX-270-308

Revised 10-Apr-08

Sirtinol
SYNONYMS	Sir Two Inhibitor Naphthol 2-[(2-Hydroxynaphthalen-1-yl-methylene)amino]-N-(1-phenethyl)benzamide
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Sirtuins/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-308-M001		1 mg	53.00 USD
ALX-270-308-M005		5 mg	160.00 USD

Product Specification

FORMULA:	C₂₆H₂₂N₂O₂
MW:	394.5
PURITY:	≥97% (HPLC)
APPEARANCE:	Off-white to yellow crystals.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Relatively unstable in aqueous solution, especially at acidic pH.
HANDLING:	Protect from light.

Product Description

Specific cell permeable inhibitor of the sirtuin family of NAD-dependent deacetylases (ySir2: IC₅₀=48µM; hSIRT1: IC₅₀=131µM; hSIRT2: IC₅₀=58µM) with no effect on human HDAC1. Reported to inhibit Sir2p transcriptional silencing activity in vivo (IC₅₀=25µM) and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p (IC₅₀=70µM) and hSIRT2 (IC₅₀=40µM) in vitro.

Product Specific Literature References

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening: C.M. Grozinger, et al.; J. Biol. Chem. 276, 38837 (2001) Abstract; Full Text
Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity: C.E. Koering, et al.; EMBO Rep. 3, 1055 (2002) Abstract; Full Text
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors: A. Mai, et al.; J. Med. Chem. 48, 7789 (2005) Abstract
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells: H. Ota, et al.; Oncogene 25, 176 (2006) Abstract

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