ALEXIS Biochemicals: Sodium 4-phenylbutyrate

ALX-270-303

Revised 13-Apr-06

Sodium 4-phenylbutyrate
SYNONYMS	SPB 4-Phenylbutyric acid 4PBA PBNa
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	HDAC Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-303-M100		100 mg	35.00 USD

Product Specification

FORMULA:	C₁₀H₁₁O₂Na
MW:	186.2
CAS NUMBER:	1716-12-7
PURITY:	≥98%
APPEARANCE:	White to yellowish solid.
SOLUBILITY:	Soluble in DMSO or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Hygroscopic.

Product Description

Inhibitor of histone deacetylase (HDAC). Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Shows chemical chaperone activity.

Product Specific Literature References

Discordant effects of butyrate analogues on erythroleukemia cell proliferation, differentiation and histone deacetylase: M.A. Lea & N. Tulsyan; Anticancer Res. 15, 879 (1995) Abstract
Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase: R.P. Warrell, Jr., et al.; J. Natl. Cancer Inst. 90, 1621 (1998) Abstract
Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors: S.D. Gore & M.A. Carducci; Expert Opin. Investig. Drugs 9, 2923 (2000), (Review) Abstract
Butyrate as a model for "gene-regulating chemoprevention and chemotherapy.": Y. Sowa & T. Sakai; Biofactors 12, 283 (2000) Abstract

Further Categories Containing This Product:

Antitumor Agents (Anti-proliferative)

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