ALEXIS Biochemicals: Sodium orthovanadate

ALX-400-032

Revised 14-May-08

Sodium orthovanadate
SYNONYMS	Decavandate Sodium vanadate
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Oxovanadates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-032-G005		5 g	15.00 USD
ALX-400-032-G025		25 g	60.00 USD

Product Specification

FORMULA:	Na₃VO₄
MW:	183.9
CAS NUMBER:	13721-39-6
RTECS:	YW1120000
PURITY:	≥90% (on dry basis)
APPEARANCE:	White to light blue powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	MAY BE MUTAGENIC. HARMFUL.

Product Description

Potent inhibitor of alkaline phosphatase and tyrosine phosphates. Regarding decavandate: across the pH range of 1-13, simple aqueous solutions of [VO₄]^3- ion involve a dozen or more ionic species, both monomeric and oligomeric, whose abundances depend strongly on pH and [VO₄]^3- concentration. At pH 3.75 a stable complex can be prepared (see below in Fohr et al.) which contains ten vanadium atoms and hence is a decavanadate ion. When diluted to pH 7.2, the decavandate species has a half-life time of about 2 hours. Fohr et al., also provide directions for generating control solutions of mixed vanadate complexes in which decavandate is absent and monomeric orthovanadate is present. Decavandate inhibits inositol 1,4,5-trisphosphate- (IP₃) induced calcium release from permeabilized endocrine cells and the binding of [³H]IP³ to its receptor in cerebellar and adrenal cortical membranes.

Product Specific Literature References

3rd Edition of interscience (New York): F.A. Cotton & G. Wilkinson; Adv. Inorg. Chem. 3, 820 (1972)
Inhibition of human alkaline phosphatases by vanadate: L.E. Seargeant and R.A. Stinson; Biochem. J. 181, 247 (1979) Abstract
Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate: G. Swarup, et al.; BBRC 107, 1104 (1982) Abstract
Characterization of the inositol 1,4,5-trisphosphate-induced calcium release from permeabilized endocrine cells and its inhibition by decavanadate and p-hydroxymercuribenzoate: K.J. Fohr, et al.; Biochem. J. 262, 83 (1989) Abstract
Is decavanadate a specific inositol 1,4,5-trisphosphate receptor antagonist? [letter]: J. Strupish, et al.; Biochem J. 277, 294 (1991) Abstract

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.