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ALX-630-044 Revised 08-Apr-08
Stichodactyla Toxin
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SYNONYMS ShK
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-044-C100   100 µg 520.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-OH
(Disulfide bonds between Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32)
FORMULA: C169H274N54O48S7
MW: 4054.8
SOURCE/HOST: Synthetic. Originally isolated from sea anemone Stichodactyla helianthus.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute in destilled water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: The aqueous solution is stable for a few weeks when stored at -20°C.
HAZARD: POTENT NEUROTOXIN.
Product Description
Voltage-dependent K+ channel (A channel) blocker. Inhibitor of T cell activation. Immunosuppressor.
Product Specific Literature References
Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus: O. Castaneda, et al.; Toxicon 33, 603 (1995) Abstract
Identification of three separate binding sites on SHK toxin, a potent inhibitor of voltage-dependent potassium channels in human T-lymphocytes and rat brain: M.W. Pennington, et al.; Biochem. Biophys. Res. Commun. 219, 696 (1996) Abstract
Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin: M.W. Pennington, et al.; Biochemistry 38, 14549 (1999) Abstract
Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile: R.E. Middleton, et al.; Biochemistry 42, 13698 (2003) Abstract
K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity: H. Wulff, et al.; J. Immunol. 173, 776 (2004) Abstract
Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases: R.S. Norton, et al.; Curr. Med. Chem. 11, 3041 (2004), (Review) Abstract
Stichodactyla helianthus peptide, a pharmacological tool for studying Kv3.2 channels: L. Yan, et al.; Mol. Pharmacol. 67, 1513 (2005) Abstract
Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes: L. Hu, et al.; J. Immunol. 179, 4563 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Immunomodulators • K+ Channel Blockers & Inhibitors
 
 
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