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Heat Shock Proteins [HSPs] / Chaperones / Related Products
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ALX-380-091 Revised 21-Aug-08
17-AAG
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SYNONYMS 17-(Allylamino)-17-desmethoxygeldanamycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-091-C100   100 µg 65.00 USD Add To Cart
ALX-380-091-M001   1 mg 162.00 USD Add To Cart
Product Specification
FORMULA: C31H43N3O8
MW: 585.7
CAS NUMBER: 75747-14-7
SOURCE/HOST: Semisynthetic derivative from geldanamycin.
PURITY: ≥97%
APPEARANCE: Red to dark red powder.
SOLUBILITY: Soluble in DMSO (10mg/ml) or methanol (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Potent, less toxic derivative of geldanamycin (Prod. No. ALX-380-054). Inhibits the essential ATPase activity of HSP90. Inhibitor of telomerase activity. Inducer of apoptosis with antitumor activity.
Product Specific Literature References
Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives: R.C. Schnur, et al.; J. Med. Chem. 38, 3806 (1995) Abstract
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin: T.W. Schulte & L.M. Neckers; Cancer Chemother. Pharmacol. 42, 273 (1998) Abstract
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone: P.A. Clarke, et al.; Oncogene 19, 4125 (2000) Abstract
Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts: R. Nimmanapalli, et al.; Cancer Res. 61, 1799 (2001) Abstract; Full Text
Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells: P.N. Munster, et al.; Cancer Res. 61, 2945 (2001) Abstract; Full Text
Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin: J. Yang, et al.; Cancer Res. 61, 4010 (2001) Abstract; Full Text
Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis: D.M. Nguyen, et al.; Ann. Thorac. Surg. 72, 371 (2001) Abstract
ErbB2 degradation mediated by the co-chaperone protein CHIP: P. Zhou, et al.; J. Biol. Chem. 278, 13829 (2003) Abstract
Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells: R. Villa, et al.; Carcinogenesis 24, 851 (2003) Abstract
Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of Cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction: I.A. Vasilevskaya, et al.; Cancer Res. 63, 3241 (2003) Abstract
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors: A. Kamal, et al.; Nature 425, 407 (2003) Abstract
Chaperoning oncogenes: HSP90 as a target of geldanamycin: L. Neckers; Handb. Exp. Pharmacol. 259 (2006) Abstract
Drugging the cancer chaperone HSP90: Combinatorial therapeutic exploitation of oncogene addiction and tumor stress: P. Workman, et al.; Ann. N.Y. Acad. Sci. 1113, 202 (2007) Abstract
Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51: Q. Yao, et al.; Clin. Cancer Res. 13, 1591 (2007) Abstract; Full Text
Phase I and pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with refractory advanced cancers: R.K. Ramanathan, et al.; Clin. Cancer Res. 13, 1769 (2007) Abstract
HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells: P.N. Meyer, et al.; Leuk. Res. 32, 143 (2008) Abstract
Intratumor injection of the Hsp90 inhibitor 17AAG decreases tumor growth and induces apoptosis in a prostate cancer xenograft model: C.R. Williams, et al.; J. Urol. 178, 1528 (2007) Abstract
Rituximab and 17-allylamino-17-demethoxygeldanamycin induce synergistic apoptosis in B-cell chronic lymphocytic leukaemia: A.J. Johnson, et al.; Br. J. Haematol. 139, 837 (2007) Abstract
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models: U. Banerji, et al.; Cancer Chemother. Pharmacol. 62, 769 (2008) Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Tyrosine Kinase Inhibitors • Antibiotics - Other Signal Transduction Pathway Modulators • HSP90 / HtpG / Related Products
 
 
ALX-201-275 Revised 18-Mar-08
Activator of HSP90 ATPase 1 (human) (recombinant)
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SYNONYMS AHA1 (human) (recombinant)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP90 / HtpG / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-275-C100   100 µg 320.00 USD Add To Cart
Product Specification
MW: ~36.1kDa
SOURCE/HOST: Produced in E.coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 20mM TRIS, pH 8.0, containing 2mM EDTA.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q12449: Activator of HSP90 ATPase-1 (human)
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-219 Revised 22-Mar-07
BiP (mouse) (recombinant)
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SYNONYMS GRP78 (mouse) (recombinant)
Glucose Regulated Protein 78 (mouse) (recombinant)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP70 / DnaK / Related Products
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ALX-201-219-C025   25 µg 170.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
PURITY: ≥99% (SDS-PAGE; MS)
FORMULATION: Liquid. In 50mM HEPES, pH 7.5, containing 150mM KCl and 10mM MgCl2.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Specific Literature References
Influence of the oxidoreductase ER57 on the folding of an antibody fab fragment: M. Mayer, et al.; J. Mol. Biol. 341, 1077 (2004) Abstract
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • Recombinant Proteins / Fusion Proteins
 
 
ALX-400-040 Revised 13-Aug-07
Cisplatin
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SYNONYMS cis-Platinum(ll)diamine dichloride
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Reagents Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-400-040-M050   50 mg 42.00 USD Add To Cart
ALX-400-040-M250   250 mg 90.00 USD Add To Cart
Product Specification
FORMULA: Cl2H6N2Pt
MW: 300.0
CAS NUMBER: 15663-27-1
MERCK INDEX: 14: 2317
RTECS: TP2450000
PURITY: ≥99% (Assay)
APPEARANCE: Off-white to orange powder.
ENDOTOXIN CONTENT: ≤1.0EU/mg
SOLUBILITY: Soluble in dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Specific Literature References
Cisplatin induces a persistent activation of JNK that is related to cell death: I. Sanchez-Perez, et al.; Oncogene 16, 533 (1998) Abstract
Telomere loss in cells treated with cisplatin: T. Ishibashi & S.J. Lippard; PNAS 95, 4219 (1998) Abstract
Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin: J. Melendez-Zajgla, et al.; Biochem. Mol. Biol. Int. 47, 765 (1999) Abstract
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage: J.G. Gong, et al.; Nature 399, 806 (1999) Abstract
Cisplatin-induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the Fas/Fas ligand system: M.S. Razzaque, et al.; Histochem. Cell Biol. 111, 359 (1999) Abstract
Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma: K. Seki, et al.; Cancer Chemother. Pharmacol. 45, 199 (2000) Abstract
Effectiveness of hsp90 inhibitors as anti-cancer drugs: L. Xiao, et al.; Mini Rev. Med. Chem. 6, 1137 (2006), (Review) Abstract
Further Categories Containing This Product:
HSP90 / HtpG / Related Products
 
 
ALX-201-209 Revised 03-Mar-05
ClpB (E. coli) (recombinant)
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PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Heat Shock Proteins Other Products
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ALX-201-209-C100   100 µg 170.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 5mg/ml.
PURITY: ≥95%
FORMULATION: Liquid. In 20mM TRIS-HCl, pH 7.8, containing 80mM sodium chloride, 5mM magnesium dichloride, 0.5mM EDTA and 10% (v/v) glycerol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network: P. Goloubinoff, et al.; PNAS 96, 13732 (1999) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-380-110 Revised 03-Apr-08
17-DMAG
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SYNONYMS 17-[2-(Dimethylamino)ethyl]amino-17-desmethoxygeldanamycin
NSC 707545
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Angiogenesis Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-110-C100   100 µg 50.00 USD Add To Cart
ALX-380-110-M001   1 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C32H48N4O8
MW: 616.8
CAS NUMBER: 150270-08-9
SOURCE/HOST: Semisynthetic from geldanamycin (Prod. No. ALX-380-054).
PURITY: ≥99%
APPEARANCE: Purple to black powder.
SOLUBILITY: Soluble in water, 100% ethanol (10mg/ml) or DMSO (>25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description

Less toxic, more potent synthetic derivative of geldanamycin. Inhibitor of angiogenesis. Inhibitor of heat shock protein 90 (HSP90). Inducer of apoptosis with higher antitumor activity than 17-AAG (Prod. No. ALX-380-091).
Product Specific Literature References
Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats: M.J. Egorin, et al.; Cancer Chemother. Pharmacol. 49, 7 (2002) Abstract
Biliary excretion of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) and metabolites by Fischer 344 rats: S.M. Musser, et al.; Cancer Chemother. Pharmacol. 52, 139 (2003) Abstract
Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90: J.M. Jez, et al.; Chem. Biol. 10, 361 (2003) Abstract
Synthesis and biological activities of novel 17-aminogeldanamycin derivatives: Z.Q. Tian, et al.; Bioorg. Med. Chem. 12, 5317 (2004) Abstract
Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator: G. Kaur, et al.; Clin. Cancer Res. 10, 4813 (2004) Abstract
Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin: E.E. Bull, et al.; Clin. Cancer Res. 10, 8077 (2004) Abstract
ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition: H. Dote, et al.; Cancer Res. 65, 6967 (2005) Abstract
In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative: M. Hollingshead, et al.; Cancer Chemother. Pharmacol. 56, 115 (2005) Abstract
Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models: V. Smith, et al.; Cancer Chemother. Pharmacol. 56, 126 (2005) Abstract
Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance: E.R. Glaze, et al.; Cancer Chemother. Pharmacol. 56, 637 (2005) Abstract
17-Allyamino-17-demethoxygeldanamycin and 17-NN-dimethyl ethylene diamine-geldanamycin have cytotoxic activity against multiple gynecologic cancer cell types: D.R. Gossett, et al.; Gynecol. Oncol. 96, 381 (2005) Abstract
Structure-based design of 7-carbamate analogs of geldanamycin: G. Rastelli, et al.; Biooorg. Med. Chem. Lett. 15, 5016 (2005) Abstract
Generation of a novel anti-geldanamycin antibody: E. Barzilay, et al.; BBRC 330, 561 (2005) Abstract
Determination of the heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin in plasma by liquid chromatography-electrospray mass spectrometry: K. Hwang, et al.; J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 830, 35 (2006) Abstract
Related Products
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Tyrosine Kinase Inhibitors • Antitumor Antibiotics • HSP90 / HtpG / Related Products
 
 
ALX-201-143 Revised 18-May-05
DnaK (E. coli) (recombinant)
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SYNONYMS Heat Shock Protein 70 (E. coli) (recombinant)
HSP70 (E. coli) (recombinant)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP70 / DnaK / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-143-C025   25 µg 135.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
CONCENTRATION:  
PURITY: ≥99%
FORMULATION: Liquid. In 20mM TRIS/HCl, pH 7.2, containing 100mM NaCl, 40mM KCl, 0.1mM EDTA, 1mM DTT and 5% glycerol.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Specific Literature References
The unfolding story of the Escherichia coli Hsp70 DnaK: is DnaK a holdase or an unfoldase?: S.V. Slepenkov & S.N. Witt; Mol. Microbiol. 45, 1197 (2002), (Review) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P04475: Chaperone protein dnaK (E. coli)
General Literature References
Protein folding and degradation in bacteria: to degrade or not to degrade? That is the question: D.A. Dougan, et al.; Cell. Mol. Life Sci. 59, 1607 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-217 Revised 13-Aug-07
DnaK (1-638) (E. coli) (recombinant)
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SYNONYMS HSP70 (1-638) (E. coli) (recombinant)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP70 / DnaK / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-217-C100   100 µg 125.00 USD Add To Cart
Product Specification
MW: ~69kDa
SOURCE/HOST: Recombinant full length DnaK produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 25mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 5mM DTT and 10% glycerol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-187 Revised 10-Feb-05
DnaK (ATPase Domain) (1-384) (recombinant)
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PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP70 / DnaK / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-187-C100   100 µg 125.00 USD Add To Cart
Product Specification
MW: ~41.6kDa.
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 25mM TRIS-HCl, pH 7.5, containing 100mM NaCl, 5mM DTT and 10% glycerol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Literature References
Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous: J.C. Bardwell & E.A. Craig; PNAS 81, 848 (1984) Abstract
Structural analysis of substrate binding by the molecular chaperone DnaK: X. Zhu, et al.; Science 272, 1606 (1996) Abstract
The substrate binding domain of DnaK facilitates slow protein refolding: N. Tanaka, et al.; PNAS 99, 15398 (2003) Abstract; Full Text
Further Categories Containing This Product:
Enzymes • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-186 Revised 10-Feb-05
DnaK (Substrate Binding Domain) (385-546) (recombinant)
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PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP70 / DnaK / Related Products
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ALX-201-186-C100   100 µg 125.00 USD Add To Cart
Product Specification
MW: ~17.8kDa.
SOURCE/HOST: Produced in E. coli. Substrate binding domain of DnaK (aa 385-546) with an additional methionine attached at the N-terminus.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 25mM TRIS-HCl, pH 7.5, containing 2mM β-mercaptoethanol and 1mM EDTA.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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