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ALX-201-154
Revised 10-Feb-05
HSP104 (yeast) (recombinant)
SYNONYMS
Heat Shock Protein 104 (yeast) (recombinant)
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
Heat Shock Proteins Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-154-C025
25 µg
155.00 USD
Product Specification
SOURCE/HOST:
Produced in yeast.
CONCENTRATION:
4.7mg/ml
PURITY:
≥99%
FORMULATION:
Liquid. In 20mM TRIS/HCl, pH 8.0, containing 1mM DTT.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Specific Literature References
Purification and properties of Hsp104 from yeast:
E.C. Schirmer & S. Lindquist; Methods Enzymol.
290
, 430 (1998)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P31539:
Heat shock protein 104 (
Saccharomyces cerevisiae
(Baker's yeast))
General Literature References
HSP100/Clp proteins: a common mechanism explains diverse functions
:
E.C. Schirmer, et al.; Trends Biochem. Sci.
21
, 289 (1996), (Review)
Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
ALX-201-146
Revised 10-Feb-05
HtpG (E. coli) (recombinant)
SYNONYMS
Heat Shock Protein 90 (
E. coli
) (recombinant)
HSP90 (
E. coli
) (recombinant)
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
HSP90/HtpG/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-146-C025
25 µg
155.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
.
CONCENTRATION:
4mg/ml
PURITY:
≥99%
FORMULATION:
Liquid. In 40mM HEPES/KOH, pH 7.5, containing 20mM KCl and 5% glycerol.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Specific Literature References
Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli
:
J.C. Bardwell & E.A. Craig; PNAS
84
, 5177 (1987)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P10413:
Chaperone protein htpG (
E. coli
)
General Literature References
Heat-shock protein 90, a chaperone for folding and regulation
:
D. Picard; Cell. Mol. Life Sci.
59
, 1640 (2002), (Review)
Abstract
Further Categories Containing This Product:
Ubiquitin-conjugating Enzymes [E2]
•
Recombinant Proteins/Fusion Proteins
ALX-270-292
Revised 09-Feb-05
1L-6-Hydroxymethyl-chiro-inositol-2-[(R)-2-O-methyl-3-O-octadecylcarbonate]
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphoinositide 3-kinase [PI(3)K]/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-292-M001
1 mg
85.00 USD
ALX-270-292-M005
5 mg
330.00 USD
Product Specification
FORMULA:
C
30
H
58
O
10
MW:
578.8
PURITY:
>98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Potent inhibitor of Akt (PKB) (IC
50
=2.0µM). Weak inhibitor of PI(3)K (phosphoinositide 3-kinase) (IC
50
=83µM). Has been shown to inhibit the growth of the following cancer cell lines: HeLa (IC
50
=2.5µM), HT-29 (IC
50
=10µM), MCF-7 (IC
50
=1.2µM) and PC-3 (IC
50
=2.0µM).
Product Specific Literature References
3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth:
Y. Hu, et al.; J. Med. Chem.
43
, 3045 (2000)
Abstract
Further Categories Containing This Product:
Akt [PKB]/Related Products
•
Protein Kinase Inhibitors Other Products
•
Antitumor Agents (Enzyme Inhibitors)
ALX-307-003
Revised 19-Aug-08
myo-Inositol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-307-003-G025
25 g
18.00 USD
Product Specification
FORMULA:
C
6
H
12
O
6
MW:
180.2
CAS NUMBER:
87-89-8
MERCK INDEX:
14:
4978
RTECS:
NM7520800
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water; slightly soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
IDENTITY:
Identity determined by IR.
ALX-307-004
Revised 04-Apr-07
scyllo-Inositol
SYNONYMS
Scyllitol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-307-004-M005
5 mg
45.00 USD
ALX-307-004-M025
25 mg
180.00 USD
Product Specification
FORMULA:
C
6
H
12
O
6
MW:
180.2
CAS NUMBER:
488-59-5
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Naturally occuring isomer of
myo
-inositol (Prod. No.
ALX-307-003
).
Product Specific Literature References
In vivo conversion of [3H]myoinositol to [3H]chiroinositol in rat tissues:
Y. Pak, et al.; J. Biol. Chem.
267
, 16904 (1992)
Abstract
;
Full Text
Phosphoinositide metabolism in the developing conceptus. Effects of hyperglycemia and scyllo-inositol in rat embryo culture:
P.J. Strieleman, et al.; Diabetes
41
, 989 (1992)
Abstract
ALX-307-028
Revised 27-Jun-05
D-myo-Inositol 1,5-bisphosphate . tetrapotassium salt
SYNONYMS
Ins(1,5)P
2
. 4K
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-307-028-C100
100 µg
60.00 USD
ALX-307-028-M001
1 mg
280.00 USD
Product Specification
FORMULA:
C
6
H
10
O
12
P
2
. 4K
MW:
336.1 . 156.4
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR and MS.
General Information
MANUFACTURER
Manufactured by SiChem, Germany.
ALX-307-027
Revised 27-Jun-05
DL-myo-Inositol 1,5-bisphosphate . dipotassium salt
SYNONYMS
DL-Ins(1,5)P
2
. 2K
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-307-027-C100
100 µg
60.00 USD
ALX-307-027-M001
1 mg
280.00 USD
Product Specification
FORMULA:
C
6
H
12
O
12
P
2
. 2K
MW:
338.1 . 78.2
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR and MS.
General Information
MANUFACTURER
Manufactured by SiChem, Germany.
ALX-307-038
Revised 06-Dec-07
D-myo-Inositol 3,4-bisphosphate, L-α-Phosphatidyl-(1,2-dipalmitoyl)-
SYNONYMS
PtdIns(3,4)P
2
, (1,2-dipalmitoyl)-
L-α-Phosphatidyl-(1,2-dipalmitoyl)-D-
myo
-inositol 3,4-bisphosphate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-307-038-C100
100 µg
95.00 USD
ALX-307-038-C500
500 µg
320.00 USD
Product Specification
FORMULA:
C
41
H
81
O
19
P
3
MW:
971.0
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR,
13
C-NMR and MS.
Product Specific Literature References
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate:
T.F. Franke, et al.; Science
275
, 665 (1997)
Abstract
General Information
MANUFACTURER
Manufactured by SiChem, Germany
ALX-307-039
Revised 12-May-06
D-myo-Inositol 4,5-bisphosphate, L-α-Phosphatidyl-(1,2-dipalmitoyl)-
SYNONYMS
PtdIns(4,5)P
2
, (1,2-dipalmitoyl)-
L-α-Phosphatidyl-(1,2-dipalmitoyl)-D-
myo
-inositol 4,5-bisphosphate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-307-039-C100
100 µg
95.00 USD
Product Specification
FORMULA:
C
41
H
81
O
19
P
3
MW:
971.0
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR,
13
C-NMR and MS.
Product Description
The presence of 4,5-bisphosphate group on the inositol ring has been found critical for binding specifically to PH domains that are commonly present in signalling proteins, also found in cytoskeleton.
Product Specific Literature References
Structure of the binding site for inositol phosphate in a PH domain:
M. Hyvonen, et al.; EMBO J.
14
, 4676 (1995)
Abstract
Inositolpolyphosphates and their binding proteins--a short review:
B. Huisamen & A. Lochner; Mol. Cell. Biochem.
157
, 229 (1996)
Abstract
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate:
T.F. Franke, et al.; Science
275
, 665 (1997)
Abstract
Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking:
T.F. Martin; Annu. Rev. Cell. Dev. Biol.
14
, 231 (1998), (Review)
Abstract
The synthesis and cellular roles of phosphatidylinositol 4,5- bisphosphate:
A. Toker; Curr. Opin. Cell Biol.
10
, 254 (1998)
Abstract
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5- bisphosphate:
R. Rohatgi, et al.; J. Cell Biol.
150
, 1299 (2000)
Abstract
General Information
MANUFACTURER
Manufactured by SiChem, Germany
ALX-307-026
Revised 18-Aug-08
D-myo-Inositol 1-monophosphate . dipotassium salt
SYNONYMS
Ins(1)P
1
. 2K
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-307-026-M001
1 mg
63.00 USD
ALX-307-026-M005
5 mg
158.00 USD
Product Specification
FORMULA:
C
6
H
11
O
9
P . 2K
MW:
258.1 . 78.2
CAS NUMBER:
573-35-3
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic. Protect from light and moisture.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR and MS.
General Information
MANUFACTURER
Manufactured by SiChem, Germany.
ALX-307-080
Revised 23-Jun-05
D-myo-Inositol 3-monophosphate, L-α-Phosphatidyl-(1,2-dipalmitoyl)-
SYNONYMS
PtdIns(3)P
1
, (1,2-dipalmitoyl)-
L-α-Phosphatidyl-(1,2-dipalmitoyl)-D-
myo
-inositol 3-monophosphate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Inositols & Inositolphosphates/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-307-080-C100
100 µg
60.00 USD
ALX-307-080-M001
1 mg
380.00 USD
Product Specification
FORMULA:
C
41
H
80
O
16
P
2
MW:
891.0
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
IDENTITY:
Identity determined by
1
H-NMR,
31
P-NMR,
13
C-NMR and MS.
General Information
MANUFACTURER
Manufactured by SiChem, Germany
ALX-307-081
Revised 23-Jun-05
