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Stress & Heat Shock Proteins
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ALX-270-063 Revised 03-Apr-08
Cantharidin
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SYNONYMS Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-063-M025   25 mg 50.00 USD Add To Cart
ALX-270-063-M100   100 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C10H12O4
MW: 196.2
CAS NUMBER: 56-25-7
MERCK INDEX: 14: 1752
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone, DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Potent protein phosphatase 2A (PP2A) inhibitor. At higher concentrations, also inhibits protein phosphatase 1 (PP1).
Product Specific Literature References
Partial characterization of specific cantharidin binding sites in mouse tissues: M.J. Graziano, et al.; Mol. Pharmacol. 33, 706 (1988) Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A: Y.-M. Li and J.E. Casida; PNAS 89, 11867 (1992) Abstract
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues: Y.-M. Li, et al.; Biochem. Pharmacol. 46, 1435 (1993) Abstract
Further Categories Containing This Product:
PP2A/Related Products
 
 
ALX-550-084 Revised 13-Dec-04
Carbamazepine
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SYNONYMS 5H-Dibenz[b,f]azepine-5-carboxamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Benzodiazepines/Related Products
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ALX-550-084-G001   1 g 10.00 USD Add To Cart
ALX-550-084-G005   5 g 30.00 USD Add To Cart
Product Specification
FORMULA: C15H12N2O
MW: 236.3
CAS NUMBER: 298-46-4
MERCK INDEX: 14: 1781
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in ethanol. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Anticonvulsant and analgesic.
Further Categories Containing This Product:
Analgesic/Anti-nociceptive Agents/Related Products • Autophagy Other Products
 
 
ALX-201-093 Revised 15-Apr-08
Caspase-4 (active) (human) (recombinant)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspases
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-093-U025   25 U 203.00 USD Add To Cart
ALX-201-093-U100   100 U 371.00 USD Add To Cart
Product Specification
EC: 3.4.22.57
SOURCE/HOST: Produced in E. coli.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with PBS containing 15% glycerol to 1U/µl.
SPECIFIC ACTIVITY: ~5'000U/mg protein. One unit is defined as the amount of enzyme that cleaves 1nmol of the caspase substrate WEHD-pNA per hour at 37°C in reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT.
APPLICATION: Useful in screening caspase inhibitors, studying enzyme regulation and kinetics, determining target substrate or as a positive control in caspase activity assays. We recommend using 1 unit per assay for analyzing caspase activity.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
General Information
Caspase-4 is a member of the caspase family of cysteine proteases. It exists in cells as an inactive pro-enzyme. The pro-enzyme is matured by proteolysis to yield large and small subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. The expressed caspase-4 spontaneously undergoes auto-processing to yield subunits characteristic of the native enzyme. The active caspase-4 is routinely tested for its ability to enzymatically cleave the substrate WEHD-AFC or WEHD-pNA.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P49662: Caspase-4 (human) (precursor)
AfCS Signalling Gateway link A000499: Caspase-4 (mouse)
Further Categories Containing This Product:
Enzymes • Recombinant Proteins/Fusion Proteins • Endoplasmatic Reticulum Stress
 
 
ALX-201-148 Revised 16-Feb-05
Cdc37 (yeast) (recombinant)
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SYNONYMS Cell Division Control Protein 37 (yeast) (recombinant)
HSP90 Co-chaperone Cdc37 (yeast) (recombinant)
HSP90 Chaperone Protein Kinase-targeting Subunit (yeast) (recombinant)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Co-Chaperones & HSP-interacting Proteins/Related Products
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ALX-201-148-C025   25 µg 155.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1.7mg/ml
PURITY: ≥99%
FORMULATION: Liquid. In 50mM TRIS/HCl, pH 7.5, containing 50mM NaCl, 5mM EDTA and 1mM DTT.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Specific Literature References
Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37: G. Siligardi, et al.; J. Biol. Chem. 277, 20151 (2002) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P06101: HSP90 Co-chaperone Cdc73 (Saccharomyces cerevisiae (Baker's yeast))
General Literature References
Heat-shock protein 90, a chaperone for folding and regulation: D. Picard; Cell. Mol. Life Sci. 59, 1640 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-350-332 Revised 03-Apr-08
Celastrol
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SYNONYMS Tripterine
3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-332-M005   5 mg 65.00 USD Add To Cart
ALX-350-332-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C29H38O4
MW: 450.6
CAS NUMBER: 34157-83-0
SOURCE/HOST: Isolated from the root of Tripterygium sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Red cubic crystals.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable triterpenoid anti-inflammatory and immunosuppressive compound. Antioxidant. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC50=40nM for IL-1β and IL-1α, 80nM for IL-6, 110nM for prostaglandin E2 and 210nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC50=230nM) and LPS-induced NF-κB activation (IC50=270nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC50=2.5µM). Inhibits lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50=7µM). Induces expression of a wider set of heat shock proteins. Inhibits topoisomerse II.
Product Specific Literature References
The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria: H. Sassa, et al.; BBRC 172, 890 (1990) Abstract
Structural basis of potent antiperoxidation activity of the triterpene celastrol in mitochondria: effect of negative membrane surface charge on lipid peroxidation: H. Sassa, et al.; Free Radic. Biol. Med. 17, 201 (1994) Abstract
Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine: W. He, et al.; Bioorg. Med. Chem. Lett. 8, 3659 (1998) Abstract
Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer’s disease: A.C. Allison, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341 (2001) Abstract
Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production: H.Z. Jin, et al.; J. Nat. Prod. 65, 89 (2002) Abstract
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol: M. Nagase, et al.; Biosci. Biotechnol. Biochem. 67, 1883 (2003) Abstract; Full Text
Celastrol inhibits pro-inflammatory cytokine secretion in Crohn’s disease biopsies: G.F. Pinna, et al.; BBRC 322, 778 (2004) Abstract
Celastrols as inducers of the heat shock response and cytoprotection: S.D. Westerheide, et al.; J. Biol. Chem. 279, 56053 (2004) Abstract; Full Text
Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity: C. Cleren, et al.; J. Neurochem. 94, 995 (2005) Abstract
Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis: M. Kiaei, et al.; Neurodegener. Dis. 2, 246 (2005) Abstract
Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice: H. Yang, et al.; Cancer Res. 66, 4758 (2006) Abstract; Full Text
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation: G. Sethi, et al.; Blood 109, 2727 (2007) Abstract
Induction of heat shock proteins in differentiated human and rodent neurons by celastrol: A.M. Chow & I.R. Brown; Cell Stress Chaperones 12, 237 (2007) Abstract
Further Categories Containing This Product:
NF-kB Pathway Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Stress & Heat Shock Proteins Other Products • Natural Products - Immunomodulators • Natural Products - Topoisomerase Inhibitors • Ubiquitin & Proteasome Other Products • Natural Products - Antioxidants
 
 
ALX-850-307 Revised 29-Apr-05
Chaperone Cocktail
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PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Stress & Heat Shock Proteins Other Products
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ALX-850-307-KI01   1 Kit 590.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
QUANTITY: 85µl
CONCENTRATION: 2.4mg/ml total protein.
KIT/SET CONTAINS: Contains the following recombinant E. coli proteins:
ClpB (10µM)
DnaK (10µM)
DnaJ (2µM)
GrpE (1µM)
GroEL (10µM)
GroES (10µM)
PURITY: ≥95%
FORMULATION: Liquid. In 50mM TRIS-HCl, pH 7.5, containing 50mM sodium chloride, 5mM magnesium dichloride and 5% (v/v) glycerol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Description
High power chaperone mix which mediates the ATP-dependent refolding of aggregated proteins (i.e. inclusion bodies).
Product Specific Literature References
Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network: P. Goloubinoff, et al.; PNAS 96, 13732 (1999) Abstract; Full Text
Further Categories Containing This Product:
Panels/Sets
 
 
ALX-201-215 Revised 02-Apr-08
CHIP (human) (recombinant)
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SYNONYMS C-terminus of HSC70 Interacting Protein
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Co-Chaperones & HSP-interacting Proteins/Related Products
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ALX-201-215-C025   25 µg 160.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥99%
FORMULATION: Liquid. In 50mM HEPES/KOH, pH 7.0, containing 50mM potassium chloride, 5mM DTT and 10% (v/v) glycerol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Dimerization of the human E3 ligase CHIP via a coiled-coil domain is essential for its activity: R. Nikolay, et al.; J. Biol. Chem. 279, 2673 (2004) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • Chaperone-mediated Autophagy [CMA] • Ubiquitin Ligases [E3]
 
 
ALX-270-437 Revised 04-Jun-08
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Sirtuins/Related Products
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ALX-270-437-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C13H13ClN2O
MW: 248.7
CAS NUMBER: 49843-98-3
PURITY: ≥95%
APPEARANCE: White to beige powder.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at -20°C in the dark.
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Specific cell permeable inhibitor. Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC50=98nM in vivo / IC50=38nM in vitro; compared to hSIRT2: IC50=19µM and hSIRT3: IC50=48µM) with no effect on human histone deacetylases (HDACs) class I and class II, nor NAD glycohydrolase (IC50>100µg). Inhibits the deacetylation of p53 (IC50=1µM).
Product Specific Literature References
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1: A.D. Napper, et al.; J. Med. Chem. 48, 8045 (2005) Abstract
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes: J.C. Milne, et al.; Nature 450, 712 (2007) Abstract
Further Categories Containing This Product:
p53 Other Products
 
 
ALX-400-040 Revised 13-Aug-07
Cisplatin
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SYNONYMS cis-Platinum(ll)diamine dichloride
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Reagents Other Products
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ALX-400-040-M050   50 mg 42.00 USD Add To Cart
ALX-400-040-M250   250 mg 90.00 USD Add To Cart
Product Specification
FORMULA: Cl2H6N2Pt
MW: 300.0
CAS NUMBER: 15663-27-1
MERCK INDEX: 14: 2317
RTECS: TP2450000
PURITY: ≥99% (Assay)
APPEARANCE: Off-white to orange powder.
ENDOTOXIN CONTENT: ≤1.0EU/mg
SOLUBILITY: Soluble in dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Specific Literature References
Cisplatin induces a persistent activation of JNK that is related to cell death: I. Sanchez-Perez, et al.; Oncogene 16, 533 (1998) Abstract
Telomere loss in cells treated with cisplatin: T. Ishibashi & S.J. Lippard; PNAS 95, 4219 (1998) Abstract
Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin: J. Melendez-Zajgla, et al.; Biochem. Mol. Biol. Int. 47, 765 (1999) Abstract
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage: J.G. Gong, et al.; Nature 399, 806 (1999) Abstract
Cisplatin-induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the Fas/Fas ligand system: M.S. Razzaque, et al.; Histochem. Cell Biol. 111, 359 (1999) Abstract
Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma: K. Seki, et al.; Cancer Chemother. Pharmacol. 45, 199 (2000) Abstract
Effectiveness of hsp90 inhibitors as anti-cancer drugs: L. Xiao, et al.; Mini Rev. Med. Chem. 6, 1137 (2006), (Review) Abstract
Further Categories Containing This Product:
HSP90/HtpG/Related Products
 
 
ALX-201-209 Revised 03-Mar-05
ClpB (E. coli) (recombinant)
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PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Heat Shock Proteins Other Products
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ALX-201-209-C100   100 µg 170.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 5mg/ml.
PURITY: ≥95%
FORMULATION: Liquid. In 20mM TRIS-HCl, pH 7.8, containing 80mM sodium chloride, 5mM magnesium dichloride, 0.5mM EDTA and 10% (v/v) glycerol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network: P. Goloubinoff, et al.; PNAS 96, 13732 (1999) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins