• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Stress & Heat Shock Proteins
You are here: Product Lines > Stress & Heat Shock Proteins
 
Toolbar - View Selection
 
 Items 140-160 of 328 Page 8 of 17 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-803-323 Revised 27-May-08 New product
Monoclonal Antibody to BAG-3 (AC-1)
Add to Clipboard
SYNONYMS anti-Bcl-2-binding Athanogene-3 MAb (AC-1)
anti-Docking Protein CAIR-1 MAb (AC-1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-323-C100   100 µg 280.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: AC-1
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 18-33 (D18RDPLPPGWEIKIDPQ33) of N-terminal human BAG-3 (Bcl-2-binding athanogene 3).
SPECIFICITY: Recognizes human, mouse and rat BAG-3.
APPLICATION: ELISA
Immunocytochemistry
Immunohistochemistry
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Bag3 gene expression is regulated by heat shock factor 1: S. Franceschelli, et al.; J. Cell Physiol. 215, 575 (2008) Abstract
General Information
BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-3 (CAIR-1; Bis) forms a complex with HSC70 and assists in polypeptide folding. In addition, this complex can mediate protein delivery to proteasome and is able to downregulate apoptosis by interfering with cytochrome c release, apoptosome assembly and other events. In human cancer cell lines, BAG-3 expression sustains cell survival and underlies resistance to therapy through downmodulation of apoptosis.
General Literature References
BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis: M.F. Romano, et al.; Cell Death Differ. 10, 383 (2003) Abstract; Full Text
Apoptosis inhibition in cancer cells: a novel molecular pathway that involves BAG3 protein: A. Rosati, et al.; Int. J. Biochem. Cell Biol. 39, 1337 (2007) Abstract
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products • Monoclonal Antibodies
 
 
ALX-804-601 Revised 20-Jun-08
Monoclonal Antibody to BAP31 (A1/182)
Add to Clipboard
SYNONYMS anti-BCR-associated Protein BAP31 MAb (A1/182)
anti-p28 BAP31 MAb (A1/182)
anti-CDM MAb (A1/182)
anti-DXS1357E MAb (A1/182)
anti-6C6-AG Tumor-associated Antigen MAb (A1/182)
PRODUCT LINE Immunology
PRODUCT CATEGORY B Cell Receptor [BCR] & Co-Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-601-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Monkey
CLONE: A1/182
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml after reconstitution.
FORMULATION: Lyophilized. Protein G-affinity purified and gel filtrated (FPLC).
RECONSTITUTION: Reconstitute with 100µl PBS containing 0.1% sodium azide.
IMMUNOGEN: BAP31 (BCR associated protein BAP031) from Vero monkey cells.
SPECIFICITY: Recognizes human and monkey BAP31.
APPLICATION: ELISA
Flow Cytometry
Immunocytochemistry (1:1’000)
Immunohistochemistry (frozen sections)
Immunoprecipitation (2µl)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The recycling pathway of protein ERGIC-53 and dynamics of the ER-Golgi intermediate compartment: J. Klumperman, et al.; J. Cell Sci. 111, 3411 (1998) Abstract; Full Text
A novel direct interaction of endoplasmic reticulum with microtubules: D.R. Klopfenstein, et al.; EMBO J. 17, 6168 (1998) Abstract; Full Text
Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment: D.R. Klopfenstein, et al.; J. Cell Biol. 153, 1287 (2001) Abstract; Full Text
Proteomics of endoplasmic reticulum-golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46: L. Breuza, et al.; J. Biol. Chem. 279, 47242 (2004) Abstract; Full Text
Capturing protein interactions in the secretory pathway of living cells: B. Nyfeler, et al.; PNAS 102, 6350 (2005) Abstract; Full Text
The Cargo Receptors Surf4, Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)-53, and p25 Are Required to Maintain the Architecture of ERGIC and Golgi: S. Mitrovic, et al.; Mol. Biol. Cell 19, 1976 (2008) Abstract
General Information
BAP31 (B cell receptor-associated protein 31) is an integral protein of the ER membrane that forms a large hetero-oligomeric complex with the related BAP29. The cytosolic domain of BAP31 contains two identical caspase recognition sites that are preferentially cleaved by initiator caspases, including caspase-8. After activation of cell surface death receptors, human BAP31 is cleaved into a membrane-embedded fragment called p20, which induces apoptosis when expressed ectopically. The p20 fragment can mediate Ca2+-dependent apoptotic cross-talk between the ER and mitochondria, stimulating cytochrome c release. In addition to its role in apoptosis, BAP31 is a component of the ER quality control compartment and functions as a cargo receptor for ER export of transmembrane proteins such as cellubrevin, MHC class I molecules, and cytochrome P450 2C2.
General Literature References
Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria: M. Nguyen, et al.; Mol. Cell. Biol. 20, 6731 (2000) Abstract; Full Text
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol: D.G. Breckenridge, et al.; J. Cell. Biol. 160, 1115 (2003) Abstract; Full Text
Bap31 Is an Itinerant Protein that Moves between the Peripheral ER and a Juxtanuclear Compartment Related to ER-associated Degradation: Y. Wakana, et al.; Mol. Biol. Cell 19, 1825 (2008) Abstract; Full Text
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • ER-Golgi Intermediate Compartment [ERGIC] / Related Products • Monoclonal Antibodies
 
 
ALX-804-812 Revised 20-Jun-08
Monoclonal Antibody to BAP31 (CC-1)
Add to Clipboard
SYNONYMS anti-B Cell Receptor-associated Protein BAP31 MAb (CC-1)
anti-BCR-associated Protein BAP31 MAb (CC-1)
anti-p28 BAP31 MAb (CC-1)
anti-CDM Protein MAb (CC-1)
anti-6C6-AG Tumor-associated Antigen MAb (CC-1)
anti-DXS1357E MAb (CC-1)
PRODUCT LINE Immunology
PRODUCT CATEGORY B Cell Receptor [BCR] & Co-Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-812-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Goat
Sheep
Monkey
Others
CLONE: CC-1
ISOTYPE: Rat IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 0.5mg/ml
PURITY: >95% (SDS-PAGE)
FORMULATION: Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: Solubilized membranes of the IMR-32 human neuroblastoma cell line.
SPECIFICITY: Recognizes an epitope (aa 230-246) encompassing a caspase recognition site and the ER-homing motif (KKEE), present at the C-terminus of human, primate, bovine and hamster BAP31. Does not recognize mouse and rat BAP31.
APPLICATION: ELISA (capture)
Immunocytochemistry (1:1'000-1:10'000; works on endogenous)
Immunohistochemistry (frozen sections (1:1'000-1:10'000); works on endogenous)
Immunoprecipitation
Western Blot (1:1'000-1:6'000; works on endogenous).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Endoplasmic reticulum membrane-sorting protein of lymphocytes (BAP31) is highly expressed in neurons and discrete endocrine cells: H.A. Manley and V.A. Lennon; J. Histochem. Cytochem. 49, 1235 (2001) Abstract; Full Text
Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils: K. Zen, et al.; J. Biol. Chem. 279, 44924 (2004) Abstract; Full Text
Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules: J.J. Ladasky, et al.; J. Immunol. 177, 6172 (2006) Abstract
General Information
BAP31 (B cell receptor-associated protein 31) is an integral protein of the ER membrane that forms a large hetero-oligomeric complex with the related BAP29. The cytosolic domain of BAP31 contains two identical caspase recognition sites that are preferentially cleaved by initiator caspases, including caspase-8. After activation of cell surface death receptors, human BAP31 is cleaved into a membrane-embedded fragment called p20, which induces apoptosis when expressed ectopically. The p20 fragment can mediate Ca2+-dependent apoptotic cross-talk between the ER and mitochondria, stimulating cytochrome c release. In addition to its role in apoptosis, BAP31 is a component of the ER quality control compartment and functions as a cargo receptor for ER export of transmembrane proteins such as cellubrevin, MHC class I molecules, and cytochrome P450 2C2.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria: M. Nguyen, et al.; Mol. Cell. Biol. 20, 6731 (2000) Abstract; Full Text
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol: D.G. Breckenridge, et al.; J. Cell. Biol. 160, 1115 (2003) Abstract; Full Text
Bap31 Is an Itinerant Protein that Moves between the Peripheral ER and a Juxtanuclear Compartment Related to ER-associated Degradation: Y. Wakana, et al.; Mol. Biol. Cell 19, 1825 (2008) Abstract; Full Text
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • ER-Golgi Intermediate Compartment [ERGIC] / Related Products • Monoclonal Antibodies
 
 
ALX-804-223 Revised 13-Mar-06
Monoclonal Antibody to Bcl-2 (human) (8C8)
Add to Clipboard
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-223-C100   100 µg 259.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 8C8
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS.
IMMUNOGEN: Synthetic peptide corresponding to aa 41-54 (G41AAPAPGIFSSQPPC54) of human Bcl-2.
SPECIFICITY: Recognizes human Bcl-2.
APPLICATION: Western Blot (0.5-1µg/ml).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. After opening aliquot contents and freeze at -20°C.
Product Specific Literature References
Movement of Bax from the cytosol to mitochondria during apoptosis: K.G. Wolter, et al.; J. Cell Biol. 139, 1281 (1997) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-660 Revised 15-Jan-08
Monoclonal Antibody to Bcl-XL (1C2)
Add to Clipboard
SYNONYMS anti-BCL2L1 MAb (1C2)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-X / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-660-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 1C2
ISOTYPE: Rat IgG2aκ
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse Bcl-XL (aa 1-209).
SPECIFICITY: Recognizes human and mouse Bcl-XL.
APPLICATION: ELISA
Flow Cytometry
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins: S.N. Willis, et al.; Genes Dev. 19, 1294 (2005) Abstract; Full Text
Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak: R.T. Uren, et al.; J. Cell Biol. 177, 277 (2007) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-658 Revised 27-Aug-07
Monoclonal Antibody to Bcl-XL (9C9)
Add to Clipboard
SYNONYMS anti-BCL2L1 MAb (9C9)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-X / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-658-C100   100 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 9C9
ISOTYPE: Rat IgG1κ
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recominant mouse Bcl-XL (aa 1-209).
SPECIFICITY: Recognizes human and mouse Bcl-XL.
APPLICATION: ELISA
Flow Cytometry
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-367 Revised 10-Oct-07
Monoclonal Antibody to Bif-1 (human) (30A882.1.1)
Add to Clipboard
SYNONYMS anti-Bax Interacting Factor-1 (human) MAb (30A882.1.1)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Interacting Proteins / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-367-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 30A882.1.1
ISOTYPE: Mouse IgG
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Recombinant human Bif-1 (Bax interacting factor-1).
SPECIFICITY: Recognizes human Bif-1.
APPLICATION: Western Blot (1-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY:

Stable for 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax: S.M. Cuddeback, et al.; J. Biol. Chem. 276, 20559 (2001) Abstract; Full Text
Endophilin B1 is required for the maintenance of mitochondrial morphology: M. Karbowski, et al.; J. Cell Biol. 166, 1027 (2004) Abstract
Further Categories Containing This Product:
Autophagy Other Products • Monoclonal Antibodies
 
 
ALX-804-014 Revised 18-Sep-08
Monoclonal Antibody to Calnexin (human) (AF18)
Add to Clipboard
SYNONYMS anti-p88 (human) MAb (AF18)
anti-IP90 (human) MAb (AF18)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Endoplasmatic Reticulum Stress
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-014-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: AF18
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Focus human hepatoma cell line.
SPECIFICITY: Recognizes human and mouse calnexin. Detects a band of ~90kDa by Western blot.
APPLICATION: Immunocytochemistry (1:500)
Immunoprecipitation
Western Blot (1:4’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene: K. Galvin, et al.; PNAS 89, 8452 (1992) Abstract; Full Text
Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm: P.P. Li, et al.; PNAS 99, 1353 (2002) Abstract; Full Text
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction: B.N. Desai, et al.; PNAS 99, 4319 (2002) Abstract; Full Text
c-erbB-3: a nuclear protein in mammary epithelial cells: M. Offterdinger, et al.; J. Cell Biol. 157, 929 (2002) Abstract; Full Text
Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator: H. Zhang, et al.; J. Biol. Chem. 277, 28948 (2002) Abstract; Full Text
Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex: J. Enninga, et al.; Mol. Cell. Biol. 23, 7271 (2003) Abstract; Full Text
Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER: R. Khanna, et al.; J. Cell Sci. 117, 2897 (2004) Abstract; Full Text
An LQT mutant minK alters KvLQT1 trafficking: A. Krumerman, et al.; Am. J. Physiol. Cell Physiol. 286, C1453 (2004) Abstract
The stop transfer sequence of the human UDP-glucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms: L. Barre, et al.; Febs J. 272, 1063 (2005) Abstract; Full Text
The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma: K.T. Chin, et al.; Nucl. Acids Res. 33, 1859 (2005) Abstract; Full Text
Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis: H. Zhang, et al.; J. Biol. Chem. 281, 11312 (2006) Abstract; Full Text
General Information
Calnexin, also referred to as IP90 or p88, is a ~88kDa chaperone protein found in the endoplastmic reticulum. It binds with partially folded immunoglobulin proteins and retains them in the endoplastmic reticulum until they are completely folded.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-509 Revised 14-Aug-07
Monoclonal Antibody to Caspase-12 (mouse) (11F10)
Add to Clipboard
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-509-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 11F10
ISOTYPE: Rat IgG1
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: p20 fragment of mouse caspase-12 and synthetic peptide corresponding to aa 183-205 (N183KKFDYLFDRDNADTDILNMQEL205) of mouse caspase-12.
SPECIFICITY: Recognizes an epitope within the p20 fragment of mouse caspase-12. Detects a band of ~51kDa by Western blot. Does not cross-react with mouse caspase-1 or -11.
APPLICATION: ELISA
Flow Cytometry
Western Blot
Other applications not tested.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References