ALEXIS Biochemicals: Swainsonine

ALX-350-077

Revised 30-Jun-08

Swainsonine
SYNONYMS	8α,β-Octahydroindolizidine-1α,2α,8β-triol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-077-MC05		0.5 mg	85.00 USD
ALX-350-077-M001		1 mg	148.00 USD

Product Specification

FORMULA:	C₈H₁₅NO₃
MW:	173.2
CAS NUMBER:	72741-87-8
SOURCE/HOST:	Synthetic.
PURITY:	≥98% (TLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO, methanol or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Reversibly inhibits the active site of lysosomal α-mannosidase. Also inhibits the growth of tumors and prevents metastasis in murine models. Could inhibit cell proliferation in vitro and the growth of human gastric carcinoma in vivo. Blocks the processing of high mannose oligosaccharides to form complex type oligosaccharides.

Product Specific Literature References

Inhibitors of glycoprotein synthesis: A.D. Elbein; Meth. Enzymol. 98, 135 (1983) Abstract
Purification and characterization of Ca2+/calmodulin-dependent protein kinase V from rat cerebrum: H. Mochizuki, et al.; J. Biol. Chem. 268, 9143 (1993) Abstract; Full Text
Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity: J.L. Klein, et al.; Br. J. Cancer 80, 87 (1999) Abstract
Swainsonine stimulates bone marrow cell proliferation and differentiation in different strains of inbred mice: O.A. Oredipe, et al.; Pharmacol. Res. 47, 69 (2003) Abstract
Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine: J.Y. Sun, et al.; Phytomedicine 14, 353 (2007) Abstract

Further Categories Containing This Product:

Alkaloids • Natural Products with Antibiotic Activity • Glycosidases / Related Products

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.