ALEXIS Biochemicals: T-2 Toxin

ALX-630-101

Revised 13-May-08

T-2 Toxin
SYNONYMS	4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Mycotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-630-101-M001		1 mg	25.00 USD
ALX-630-101-M005		5 mg	90.00 USD

Product Specification

FORMULA:	C₂₄H₃₄O₉
MW:	466.5
CAS NUMBER:	21259-20-1
RTECS:	YD0100000
SOURCE/HOST:	Isolated from Fusarium sp.
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in methylene chloride or chloroform.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HAZARD:	VERY TOXIC. MAY BE CARCINOGENIC.

Product Description

Mycotoxin. Induces DNA damage and apoptosis. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in the brain.

Product Specific Literature References

The structures of toxins from two strains of Fusarium tricinctum: J.R. Bamburg, et al.; Tetrahedron 24, 3329 (1968) Abstract
Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis: T. Ihara, et al.; Nat. Toxins 5, 141 (1997) Abstract
T-2 toxin-induced apoptosis in lymphoid organs of mice: J. Shinozuka, et al.; Exp. Toxicol. Pathol. 49, 387 (1997) Abstract
T-2 toxin induces thymic apoptosis in vivo in mice: Z. Islam, et al.; Toxicol. Appl. Pharmacol. 148, 205 (1998) Abstract
T-2 toxin-induced apoptosis in hematopoietic tissues of mice: J. Shinozuka, et al.; Toxicol. Pathol. 26, 674 (1998) Abstract
Kinetics and distribution of transforming growth factor (TGF)-beta 1 mRNA in the dorsal skin of hypotrichotic WBN/ILA-Ht rats following topical application of T-2 toxin: S.M. Albarenque, et al.; Exp. Toxicol. Pathol. 52, 297 (2000) Abstract
Thymocyte apoptosis by T-2 toxin in vivo in mice is independent of Fas/Fas ligand system: A.M. Murshedul, et al.; Biosci. Biotechnol. Biochem. 64, 210 (2000) Abstract
Kinetics of apoptosis-related genes mRNA expression in the dorsal skin of hypotrichotic WBN/ILA-ht rats after topical application of T-2 toxin: S.M. Albarenque, et al.; Exp. Toxicol. Pathol. 52, 553 (2001) Abstract
Development of apoptosis and changes in lymphocyte subsets in thymus, mesenteric lymph nodes and Peyer’s patches of mice orally inoculated with T-2 toxin: T. Nagata, et al.; Exp. Toxicol. Pathol. 53, 309 (2001) Abstract
Cytotoxicity and related effects of T-2 toxin on cultured Vero cells: C. Bouaziz, et al.; Toxicon 48, 343 (2006) Abstract