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ALX-270-309 Revised 23-Apr-08
T0901317
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SYNONYMS N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Nuclear Receptors Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-309-M010   10 mg 30.00 USD Add To Cart
ALX-270-309-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C17H12NF9O3S
MW: 481.3
CAS NUMBER: 293754-55-9
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: 50mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or any organic solvent; also soluble in a 1:1 solution of DMSO:PBS, pH 7.2 (500µg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing the aqueous solutions for more than one day.
HAZARD: HARMFUL.
IDENTITY: Identity determined by NMR.

Product Description
Potent agonist (EC50=50nM) of the orphan nuclear hormone receptor (liver X receptor; LXR). Inhibitor of human sex hormone-dependent cancer cell lines.
Product Specific Literature References
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers: J.J. Repa, et al.; Science 289, 1524 (2000) Abstract
Role of LXRs in control of lipogenesis: J.R. Schultz, et al.; Genes Dev. 14, 2831 (2000) Abstract; Full Text
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands: R.A. DeBose-Boyd, et al.; PNAS 98, 1477 (2001) Abstract; Full Text
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes: B.A. Laffitte, et al.; PNAS 98, 507 (2001) Abstract; Full Text
Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells: J. Fukuchi, et al.; Cancer Res. 64, 7686 (2004) Abstract
The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells: C.P. Chuu et al.; Biochem. Biophys. Res. Commun. 357, 341 (2007) Abstract
Further Categories Containing This Product:
Antitumor Agents (Hormone-related)
 
 
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