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ALX-270-354 Revised 03-Jul-08
TDZD-8
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SYNONYMS 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY GSK-3 Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-354-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C10H10N2SO2
MW: 222.3
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep under inert gas. Protect from light.

Product Description
Highly selective, non-ATP competitive inhibitor of GSK-3β (IC50=2µM). Binds to the active site of GSK-3β. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50>100µM).
Product Specific Literature References
First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease: A. Martinez, et al.; J. Med. Chem. 45, 1292 (2002) Abstract; Full Text
 
 
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