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ALX-430-081 Revised 22-May-08
TEMPOL
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SYNONYMS 4-OH-TEMPO
4-Hydroxy-TEMPO
4-Hydroxy-2,2,6,6-tetramethylpiperidinyloxy, free radical
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-081-M250   250 mg 15.00 USD Add To Cart
ALX-430-081-M500   500 mg 25.00 USD Add To Cart
ALX-430-081-G001   1 g 38.00 USD Add To Cart
Product Specification
FORMULA: C9H18NO2
MW: 172.2
CAS NUMBER: 2226-96-2
PURITY: ≥98% (HPLC, EPR)
APPEARANCE: Yellow to orange crystalline solid.
SOLUBILITY: Soluble in water, 100% ethanol, methanol or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Free radical scavenger useful for both in vivo and in vitro experiments.
Product Specific Literature References
Measurement of intracellular oxygen concentration using the spin label TEMPOL: P.D. Morse, 2nd & H.M. Swartz; Magn. Reson. Med. 2, 114 (1985) Abstract
Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol: J.B. Mitchell, et al.; Arch. Biochem. Biophys. 289, 62 (1991) Abstract
Tempol, a stable free radical, is a novel murine radiation protector: S.M. Hahn, et al.; Cancer Res. 52, 1750 (1992) Abstract
Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis: Z. Sledzinski, et al.; Int. J. Pancreatol. 18, 153 (1995) Abstract
A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy: M. Tal; Neuroreport 7, 1382 (1996) Abstract
Stable nitroxide radicals protect lipid acyl chains from radiation damage: A.M. Samuni & Y. Barenholz; Free Radic. Biol. Med. 22, 1165 (1997) Abstract
Tempol inhibits neutrophil and hydrogen peroxide-mediated DNA damage: S.M. Hahn, et al.; Free Radic. Biol. Med. 23, 879 (1997) Abstract
Effects of the superoxide dismutase-mimic compound TEMPOL on oxidant stress-mediated endothelial dysfunction: A.I. Haj-Yehia, et al.; Antioxid. Redox. Signal. 1, 221 (1999) Abstract
The nitroxide tempol induces oxidative stress, p21(WAF1/CIP1), and cell death in HL60 cells: M.B. Gariboldi, et al.; Free Radic. Biol. Med. 29, 633 (2000) Abstract
Nitroxide TEMPOL impairs mitochondrial function and induces apoptosis in HL60 cells: E. Monti, et al.; J. Cell. Biochem. 82, 271 (2001) Abstract
Spin trapping agents (Tempol and POBN) protect HepG2 cells overexpressing CYP2E1 against arachidonic acid toxicity: M.J. Perez & A.I. Cederbaum; Free Radic. Biol. Med. 30, 734 (2001) Abstract
Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress: L. Yanes, et al.; Am. J. Physiol. Regul. Integr.Comp. Physiol. 288, R903 (2005) Abstract
Tempol, one of nitroxides, is a novel ultraviolet-A1 radiation protector for human dermal fibroblasts: S.X. Yan, et al.; J. Dermatol. Sci. 37, 137 (2005) Abstract
Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor: L. Erker, et al.; Hum. Mol. Genet. 14, 1699 (2005) Abstract
Antioxidant enzymes and effects of tempol on the development of hypertension induced by nitric oxide inhibition: J. Sainz, et al.; Am. J. Hypertens. 18, 871 (2005) Abstract
Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson’s disease: Q. Liang, et al.; Biochem. Pharmacol. 70, 1371 (2005)
The role of oxidant stress in angiotensin II-mediated contraction of human resistance arteries in the state of health and the presence of cardiovascular disease: M.B. Hussain, et al.; Vascul. Pharmacol. 45, 395 (2006) Abstract
Acute effects of the superoxide dismutase mimetic tempol on split kidney function in two-kidney one-clip hypertensive rats: G.S. Guron, et al.; J. Hypertens. 24, 387 (2006) Abstract
The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea: H. Murashita, et al.; Hear. Res. 214, 1 (2006) Abstract
The nitroxide Tempol modulates anthracycline resistance in breast cancer cells: M.B. Gariboldi, et al.; Free Radic. Biol. Med. 40, 1409 (2006) Abstract
Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents: F. Hyodo, et al.; Cancer Res. 66, 9921 (2006) Abstract
Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells: T. Lipman, et al.; Eur. J. Pharmacol. 549, 50 (2006) Abstract
A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria: J. Trnka, et al.; Free Radic. Biol. Med. 44, 1406 (2008) Abstract
Further Categories Containing This Product:
Free Radicals/Related Products
 
 

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