ALEXIS Biochemicals: TIQ-A

ALX-270-365

Revised 01-Jul-08

TIQ-A
SYNONYMS	Thieno[2,3-c]isoquinolin-5-one
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PARP Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-365-M001		1 mg	45.00 USD
ALX-270-365-M005		5 mg	180.00 USD

Product Specification

FORMULA:	C₁₁H₇NOS
MW:	201.2
PURITY:	≥98%
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor (IC₅₀=450nM). Neuroprotectant.

Product Specific Literature References

Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia: A. Chiarugi, et al.; J. Pharmacol. Exp. Ther. 305, 943 (2003) Abstract; Full Text
Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors: R. Pellicciari, et al.; Farmaco 58, 851 (2003) Abstract

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