ALEXIS Biochemicals: TL1A, Soluble (human) ELISA Kit

APO-54N-027

Revised 01-Apr-08

TL1A, Soluble (human) ELISA Kit
SYNONYMS	TNFSF 15, Soluble (human) ELISA Kit VEGI, Soluble (human) ELISA Kit
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	HVEM & LIGHT / LT-betaR / DcR3 / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
APO-54N-027-KI01		1 Set	630.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SENSITIVITY:	15pg/ml (range 39 to 2'500pg/ml).
QUANTITY:	For 96 wells (~80 tests)
APPLICATION:	For the quantitative determination of soluble human TL1A from biological fluids (serum and cell culture supernatant).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C

General Information

TL1A (TNFSF15), a ligand belonging to the tumor necrosis factor (TNF) family, is expressed predominantly by endothelial cells and monocytes [1]. TL1a is upregulated by the proinflammatory cytokines TNF and IL-1 and also by immune complexes (IC) [2]. TL1 functions in T cell costimulation and Th1 polarization. On activated T cells, TL1A functions specifically via its surface-bound receptor DR3, (a member of the death-domain containing TNF receptor family) to promote cell survival and secretion of proinflammatory cytokines (1). The secreted decoy receptor 3 (DcR3), a soluble protein of the tumor necrosis factor receptor (TNFR) superfamily blocks the action of TL1A [3]. TL1A can be released to circulate as a homotrimeric soluble form [4]. Activation of DR3 by TL1A induced the formation of a signaling complex containing TRADD, TRAF2, and RIP and activated the NF-κB and the ERK, JNK, and p38 mitogen-activated protein kinase pathways [5]. The TL1A/DR3 pathway plays an important role in Th1-mediated intestinal diseases, such as Crohn’s disease [6].
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q8NFE9: TL1A (human)
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

[1] TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator: T.S. Migone, et al.; Immunity 16, 479 (2002) Abstract
[2] Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis: M.A. Cassatella, et al.; J. Immunol. 178, 7325 (2007) Abstract
[3] Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3: M.J. Hsu, et al.; Exp. Cell Res. 292, 241 (2004) Abstract
[4] Identification of naturally secreted soluble form of TL1A, a TNF-like cytokine: S. Kim & L. Zhang; J. Immunol. Methods 298, 1 (2005) Abstract
[5] TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells: L. Wen, et al.; J. Biol. Chem. 278, 39251 (2003) Abstract
[6] Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease: G. Bamias, et al.; J. Immunol. 171, 4868 (2003) Abstract

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