ALEXIS Biochemicals: TMB-8 . hydrochloride

ALX-550-300

Revised 07-Feb-05

TMB-8 . hydrochloride
SYNONYMS	8-(Diethylamino)octyl-3,4,5-trimethoxybenzoate . HCl
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Platelet Activating Factors [PAF] & Receptors/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-300-M025		25 mg	50.00 USD

Product Specification

FORMULA:	C₂₂H₃₇NO₅ . HCl
MW:	395.5 . 36.5
CAS NUMBER:	53464-72-5
PURITY:	≥98%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in water or ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and moisture.

Product Description

Intracellular Ca²⁺ antagonist of serum-stimulated Na⁺ influx in human fibroblasts. Inhibits platelet-activating factor (PAF) and PMA-stimulated prostaglandin production in Kupffer cells.

Product Specific Literature References

Inhibition of protein kinase C activation by 8-(N,N-diethylamino)-octyl- 3, 4, 5-trimethoxybenzoate (TMB-8), an intracellular Ca2+ antagonist: M. Sawamura; J. Med. Sci. 31, 221 (1985) Abstract
Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells: C.R. Gandhi, et al.; Biochim. Biophys. Acta 1136, 68 (1992) Abstract
Calcium-independent effects of TMB-8. Modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake: F.B. Palmer, et al.; Biochem. J. 286, 505 (1992) Abstract

Further Categories Containing This Product:

Ca2+ Modulators • Acetylcholine Receptors (Muscarinic)/Related Products • Acetylcholine Receptors (Nicotinic)/Related Products • Prostaglandins Other Products • Acetylcholine Receptors Other Products

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