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TNF & TNF Receptor Superfamily/Related Products
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ALX-850-246 Revised 11-Apr-08
FasL, Soluble (human) ELISA Kit
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SYNONYMS APO-1L, Soluble (human) ELISA Kit
CD95L, Soluble (human) ELISA Kit
CD178, Soluble (human) ELISA Kit
TNFSF 6, Soluble (human) ELISA Kit
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY FasL Kits & Sets
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-246-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.07ng/ml (range 0.16 to 10ng/ml).
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human FasL in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
CD Kits & Sets • ELISA & EIA Kits
 
 
ALX-522-131 Revised 27-Mar-08
Fc (human):RANKL, Soluble (mouse) (rec.)
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SYNONYMS Fc (human):ODF, Soluble (mouse) (recombinant)
Fc (human):OPGL, Soluble (mouse) (recombinant)
Fc (human):TRANCE, Soluble (mouse) (recombinant)
Fc (human):TNFSF 11, Soluble (mouse) (recombinant)
Fc (human):CD254, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY RANK & RANKL
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-131-C010   10 µg 390.00 USD Add To Cart
Product Specification
MW: ~55kDa
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse RANKL (aa 157-316) is fused to the Fc portion of human IgG1.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
SPECIFICITY: Binds to mouse RANK.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O35235: TNF11 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-086 Revised 08-Jan-07
Fn14 (human):Fc (human) (recombinant)
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SYNONYMS TWEAK-R (human):Fc (human) (recombinant)
TNFRSF 12A (human):Fc (human) (recombinant)
Fibroblast Growth Factor-inducible Immediate-early Response Protein 14 (human):Fc (human) (recombinant)
CD266 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TWEAK & FN14/DR3/Related Products
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ALX-522-086-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~36kDa for the chimeric protein (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human Fn14 (aa 1-75) is fused at the C-terminus to the Fc portion of human IgG1 and a linker peptide (2 aa).
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: >95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg (LAL test; BioWhittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human and mouse TWEAK.
BIOLOGICAL ACTIVITY: Inhibits TWEAK-mediated killing of Kym-1 target cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least six months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
Intraovarian TWEAK/Fn14 ligand-receptor system limits ovarian preovulatory follicles from excessive luteinization: A. De, et al.; Mol. Endocrinol. 20, 2528 (2006) Abstract; Full Text
General Information
The fibroblast growth factor-inducible-14 (Fn14) is a 129 aa type Ia transmembrane protein. Fn14 is a growth-factor regulated, immediate-early response protein. It is expressed in a developmental and adult tissue-specific manner. Fn14 expression decreases cellular adhesion to extracellular matrix proteins fibronectin and vitronectin and reduces cell growth and migration. It is expressed at high levels in liver cancer cells, in hepatocellular carcinoma specimens as well as in regenerating liver cells showing Fn14 may play a role in hepatocyte growth and liver neoplasia. Fn14 binds to TWEAK [Apo-3 Ligand], a member of the TNF family.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis: S.R. Wiley, et al.; Immunity 15, 837 (2001) Abstract
The molecular architecture of the TNF superfamily: J.L. Bodmer, et al.; TIBS 27, 19 (2002) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-036 Revised 29-Sep-05
Fn14 (mouse):Fc (human) (recombinant)
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SYNONYMS TWEAK-R (mouse):Fc (human) (recombinant)
TNFRSF 12A (mouse):Fc (human) (recombinant)
Fibroblast Growth Factor-inducible Immediate-early Response Protein 14 (mouse):Fc (human) (recombinant)
CD266 (mouse):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TWEAK & FN14/DR3/Related Products
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ALX-522-036-C050   50 µg 360.00 USD Add To Cart
ALX-522-036F-C050 FITC 50 µg 380.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~34kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse Fn14 (aa 1-75) is fused to the Fc portion of human IgG1.
CONCENTRATION: Fn14:Fc: 1mg/ml after reconstitution.
Fn14:Fc-FITC: 1mg/ml.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Fn14:Fc:  Lyophilized. Contains PBS.
Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum. After reconstitution, prepare aliquots and store at -20°C. 
Fn14:Fc-FITC: Liquid. In PBS containing 0.02% sodium azide. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; BioWhittaker).
SPECIFICITY: Binds human and mouse TWEAK.
BIOLOGICAL ACTIVITY: Inhibits TWEAK-mediated killing of Kym-1 target cells.
APPLICATION: Fn14:Fc-FITC: Flow Cytometry.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor: T.C. Polek, et al.; J. Biol. Chem. 278, 32317 (2003) Abstract; Full Text
BAFF production by antigen-presenting cells provides T cell co-stimulation: B. Huard, et al.; Int. Immunol. 16, 467 (2004) Abstract
Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis: D. Bonci, et al.; Blood 104, 3169 (2004) Abstract
General Information
The fibroblast growth factor-inducible-14 (Fn14) is a 129 aa type Ia transmembrane protein. Fn14 is a growth-factor regulated, immediate-early response protein. It is expressed in a developmental and adult tissue-specific manner. Fn14 expression decreases cellular adhesion to extracellular matrix proteins fibronectin and vitronectin and reduces cell growth and migration. It is expressed at high levels in liver cancer cells, in hepatocellular carcinoma specimens as well as in regenerating liver cells showing Fn14 may play a role in hepatocyte growth and liver neoplasia. Fn14 has recently been described to bind TWEAK [Apo-3 Ligand], a member of the TNF family.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9CR75: Fn14 (mouse) (precursor)
AfCS Signalling Gateway link A003364: Fn14 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis: S.R. Wiley, et al.; Immunity 15, 837 (2001) Abstract
The molecular architecture of the TNF superfamily: J.L. Bodmer, et al.; TIBS 27, 19 (2002), (Review) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
APO-54N-028 Revised 02-Apr-08
Free Osteoprotegerin (human) Detection Set [For ELISA Application]
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SYNONYMS Free OPG (human) Detection Set [For ELISA Application]
Free TNFRSF 11B (human) Detection Set [For ELISA Application]
Free Osteoclastogenesis Inhibitory Factor (human) Detection Set [For ELISA Application]
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY OPG
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APO-54N-028-KI01   1 Set 540.00 USD Add To Cart
Product Specification
SENSITIVITY: 2pg/ml (range 0 to 250 pg/ml).
QUANTITY: 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of human free osteoprotegerin (not bound to RANKL or TRAIL) in cell culture supernatant, plasma and serum.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
OPG (Osteoprotegerin; also called Osteoclastogenesis Inhibitory Factor or TNFRSF11B) is a secreted member of the TNF (Tumor necrosis factor) receptor superfamily of proteins [1]. OPG, composed of 380 amino acids, is expressed as monomer and secreted as disulphide-homodimeric protein [2]. Produced by numerous cell types and tissues, its expression pattern targets the skeletal, immune, and vascular systems. Osteoblasts secrete OPG that protects the skeleton from excessive bone resorption by acting as a decoy receptor for the ligand nuclear factor-κB ligand (RANKL), preventing it from interacting with its receptor RANK [3]. OPG/RANK/RANKL molecular triumvirat plays a pivotal function in the regulation of the immune system through dendritic cells [4]. OPG-deficient mice exhibit severe osteoporosis and vascular calcification of the aorta and renal arteries [5]. Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD), a bone disease [6]. OPG also functions as a soluble receptor for the TNF ligand TRAIL (TNF-related apoptosis-inducing ligand) preventing it to activate apoptotic signaling cascase and therefore providing cancer cells with a survival advantage [7].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O00300: Osteoprotegerin (human)
General Literature References
[1] Biology of RANK, RANKL, and osteoprotegerin: B.F. Boyce & L. Xing; Arthritis Res. Ther. 9 Suppl 1, S1 (2007) Abstract
[2] Osteoprotegerin: a novel secreted protein involved in the regulation of bone density: W.S. Simonet, et al.; Cell 89, 309 (1997) Abstract
[3] Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation: D.L. Lacey, et al.; Cell 93, 165 (1998) Abstract
[4] RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases: M. Baud huin, et al.; Cell Mol. Life Sci. 64, 2334 (2007) Abstract
[5] Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis: H. Min, et al.; J. Exp. Med. 192, 463 (2000) Abstract
[6] Paget’s disease of bone and genetic disorders of RANKL/OPG/RANK/NF-kappaB signaling: M.P. Whyte; Ann. N. Y. Acad. Sci. 1068, 143 (2006) Abstract
[7] Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL: J.G. Emery, et al.; J. Biol. Chem. 273, 14363 (1998) Abstract; Full Text
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-350-006 Revised 05-Apr-08
Genistein (synthetic)
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SYNONYMS 4',5,7-Trihydroxyisoflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-006-M010   10 mg 25.00 USD Add To Cart
ALX-350-006-M025   25 mg 50.00 USD Add To Cart
ALX-350-006-M050   50 mg 90.00 USD Add To Cart
ALX-350-006-M100   100 mg 150.00 USD Add To Cart
ALX-350-006-G001   1 g 480.00 USD Add To Cart
Product Specification
FORMULA: C15H10O5
MW: 270.2
CAS NUMBER: 446-72-0
MERCK INDEX: 14: 4391
RTECS: NR2392000
SOURCE/HOST: Synthetic.
PURITY: ≥99% (HPLC)
APPEARANCE: White to yellow crystalline powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or dilute aqueous base; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Tyrosine protein kinase inhibitor. Inhibits phosphorylation of EGFR kinase. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits topoisomerase II activity in vivo. Produces cell cycle arrest and apoptosis. Direct inhibitor of insulin-induced glucose uptake in adipocytes (IC50=20µM).
Product Specific Literature References
Genistein, a specific inhibitor of tyrosine-specific protein kinases: T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987) Abstract; Full Text
Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets: H. Salari, et al.; FEBS Lett. 263, 104 (1990) Abstract
Mechanisms of cancer chemoprevention by soy isoflavone genistein: F.H. Sarkar & Y. Li; Cancer Metastasis Rev. 21, 265 (2002) Abstract
Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy: N. Dijsselbloem, et al.; Biochem. Pharmacol. 68, 1171 (2004), Review Abstract
Genistein affects testosterone secretion by Leydig cells in roosters (Gallus gallus domesticus): M. Opalka, et al.; Reprod. Biol. 4, 185 (2004) Abstract
Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes: M. Bazuine, et al.; BBRC 325, 511 (2005) Abstract
Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy-containing isoflavones: Y. Huang, et al.; J. Clin. Endocrinol. Metab. 90, 3956 (2005) Abstract
Phytoestrogens and lipoproteins in women: C.N. Bairey Merz, et al.; J. Clin. Endocrinol. Metab. 91, 2209 (2006) Abstract
Clinical review: a critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations: A. Dewell, et al.; J. Clin. Endocrinol. Metab. 91, 772 (2006), Review Abstract
The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy: F.H. Sarkar, et al.; Mini Rev. Med. Chem. 6, 401 (2006), Review Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • TNF-alpha & TNF Receptors Other Products • Antitumor Agents (Enzyme Inhibitors) • Cell Cycle Blockers & Inhibitors/Related Products • EGFR Kinase Inhibitors • Natural Products - Topoisomerase Inhibitors • Natural Products for Angiogenesis Research • Natural Products - Antitumor Reagents • Flavonoids/Related Products • Active Substances from Fruit and Vegetables • Natural Products for Cell Cycle Research • Natural Products - Apoptosis Inducers & Inhibitors • Antitumor Agents (Apoptosis Inducers) • Antitumor Agents (Anti-proliferative)
 
 
ALX-522-061 Revised 31-Aug-06
GITR (human):Fc (human) (recombinant)
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SYNONYMS Glucocorticoid-induced TNFR-related Protein (human):Fc (human) (recombinant)
AITR (human):Fc (human) (recombinant)
Activation-inducible TNFR Family Receptor (human):Fc (human) (recombinant)
TNFRSF 18 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-061-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~47kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human GITR (AITR) (aa 26-161) is fused to the Fc portion of human IgG1.
QUANTITY: 50µg
CONCENTRATION: 1mg/ml.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human GITRL (AITRL).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9Y5U5: GITR (human) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-024 Revised 31-Aug-06
GITR (mouse):Fc (human) (recombinant)
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SYNONYMS Glucocorticoid-induced TNFR-related Protein (mouse):Fc (human) (recombinant)
TNFRSF 18 (mouse):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY GITR & GITRL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-024-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~45kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds mouse GITRL.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Soluble glucocorticoid-induced TNF receptor (sGITR) induces inflammation in mice: H. H. Shin, et al.; Exp. Mol. Med. 35, 358 (2003) Abstract; Full Text
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells: M. Tone, et al.; PNAS 100, 15059 (2003) Abstract
Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) stimulates osteoclast differentiation in response to receptor activator of NF-kappaB ligand (RANKL) in osteoclast cells: H.H. Shin, et al.; Bone 36, 832 (2005) Abstract
Proinflammatory role of glucocorticoid-induced TNF receptor-related gene in acute lung inflammation: S. Cuzzocrea, et al.; J. Immunol. 177, 631 (2006) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O35714: GITR (mouse) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
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