ALEXIS Biochemicals: Polyclonal Antibody to DR6 (human)

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ALX-522-019

Revised 24-Mar-05

DR6 (human):Fc (human) (recombinant)
SYNONYMS	Death Receptor-6 (human):Fc (human) (recombinant) TNFRSF 21 (human):Fc (human) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	DR6/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-019-C050		50 µg	360.00 USD

Product Specification

MW:	~83kDa (SDS-PAGE).
SOURCE/HOST:	Produced in HEK 293 cells. The cysteine-rich region of human DR6 (aa 42-335) is fused to the Fc portion of human IgG1.
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or other carrier protein.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

General Information

BACKGROUND/TECHNICAL INFORMATION	Swiss Prot link: DR6 (human) (precursor) AfCS Signalling Gateway link: DR6 (mouse)
MANUFACTURER	Manufactured by Apotech Corporation.

Related Products

ALX-203-004

Control:Fc Fusion Protein (human) (recombinant)

Further Categories Containing This Product:

Recombinant Proteins/Fusion Proteins

ALX-804-566

Revised 31-Oct-06

Monoclonal Antibody to DR6 (human) (DR-6-04-EC)
SYNONYMS	anti-Death Receptor-6 (human) MAb (DR-6-04-EC) anti-TNFRSF 21 (human) MAb (DR-6-04-EC)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	DR6/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-566-C100		100 µg	270.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	DR-6-04-EC
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml.
PURITY:	>95% (SDS-PAGE).
PURITY DETAIL:	Protein A-affinity purified.
FORMULATION:	Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN:	Recombinant human DR6 (death receptor-6) extracellular domain (aa 42-335).
SPECIFICITY:	Recognizes human DR6.
APPLICATION:	Flow Cytometry Immunoprecipitation Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at +4°C.
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Further Categories Containing This Product:

Monoclonal Antibodies

ALX-804-150

Revised 26-Feb-07

Monoclonal Antibody to DR6 (human) (Luke-1)
SYNONYMS	anti-Death Receptor-6 (human) MAb (Luke-1) anti-TNFRSF 21 (human) MAb (Luke-1)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	DR6/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-150-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	Luke-1
ISOTYPE:	Rat IgG2a
SOURCE/HOST:	Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human DR6 (death receptor-6) (aa 42-335) (Prod. No. ALX-522-019).
SPECIFICITY:	Recognizes human DR6.
APPLICATION:	Flow Cytometry
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	Avoid freeze/thaw cycles.

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General Information

Apoptosis is induced by certain cytokines including TNF and Fas ligand (CD95L) of the TNF family through their death domain containing receptors, TNF-R1 and Fas (CD95). Several novel death receptors including DR3, TRAIL-R1, and TRAIL-R2 were identified. A new death domain containing receptor in the TNF-R family was cloned and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK [1]. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified yet. T cells from DR6-deficient mice showed preference toward Th2 differentiation in vitro, suggesting that DR6, working through JNK functions to attenuate the Th2 response [2]. Other studies of DR6-targeted mutant mice demonstrated that DR6 functions as a regulatory receptor for mediating CD4(+) T cell activation and maintaining proper immune responses [3].

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

[1] Identification and functional characterization of DR6, a novel death domain-containing TNF receptor : G. Pan, et al.; FEBS Lett 431, 351 (1998) Abstract
[2] Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice : H. Zhao, et al.; J. Exp. Med. 194, 1441 (2001) Abstract; Full Text
[3] Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice: J. Liu, et al.; Immunity 15, 23 (2001) Abstract

PSC-2157	Polyclonal Antibody to DR6 (human) (NT)
ALX-522-019	DR6 (human):Fc (human) (recombinant)