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CD134 [OX40] & CD134L [OX40L] / Related Products
You are here: Product Lines > TNF & TNF Receptor Superfamily / Related Products > CD134 [OX40] & CD134L [OX40L] / Related Products
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ALX-522-022 Revised 29-Nov-05
CD134 (human):Fc (human) (recombinant)
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SYNONYMS TNFRSF 4 (human):Fc (human) (recombinant)
OX40 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-022-C050   50 µg 368.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~72kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human CD134 (OX40) (aa 29-214) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human and mouse CD134L (OX40L).
BIOLOGICAL ACTIVITY: Blocks T cell proliferation induced by CD134L.
APPLICATION: Can be used together with anti-human IgG1 PAb to detect membrane-bound human CD134L. Has been used to ameliorate graft-versus-host disease, experimental allergic encephalomyelitis and inflammatory bowel disease.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes: E. Biagi, et al.; Blood 105, 2436 (2005) Abstract
General Information
The CD134 receptor (OX40) is a member of the tumor necrosis factor receptor (TNF-R) family. CD134 is a type I transmembrane receptor. It contains 3 extracellular cysteine-rich motifs. CD134 is mainly expressed in activated lymphocytes. After interaction with its ligand CD134L (OX40L), CD134 interacts with TNF receptor-associated factor 2 (TRAF2), TRAF5 and mediate activation of nuclear factors NF-κB and AP1. CD134-CD134L have been reported to be involved in T cell selection, migration and induction of Th1 and Th2 cytokine pattern. Moreover, it is involved in anti-tumor immunity, cell adhesion and various auto-immune diseases.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P43489: CD134 (human) (precursor)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-023 Revised 20-Jun-06
CD134L, Soluble (human) (recombinant)
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SYNONYMS OX40L, Soluble (human) (recombinant)
TNFSF 4, Soluble (human) (recombinant)
CD252, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-023-C010   10 µg 200.00 USD Add To Cart
ALX-522-023-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~30kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human CD134L (OX40L) (aa 52-183) is fused at the N-terminus to a linker peptide (11 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds to human CD134 (OX40).
BIOLOGICAL ACTIVITY: Activates T cell proliferation. Delays neutrophil apoptosis.
APPLICATION: Can be used together with anti-FLAG® MAb to detect membrane-bound human CD134 (OX40).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Functional expression of CD134 by neutrophils: R. Baumann, et al.; Eur. J. Immunol. 34, 2268 (2004) Abstract
Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand: J. Dannull, et al.; Blood 105, 3206 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P23510: CD134L (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses: I. Gramaglia, et al.; J. Immunol. 161, 6510 (1998) Abstract
CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells: H. Akiba, et al.; J. Immunol. 162, 7058 (1999) Abstract
CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles: T. Brocker, et al.; Eur. J. Immunol. 29, 1610 (1999) Abstract
OX40-Mediated cosignal enhances the maturation of naive human CD4+ T cells into high IL-4-producing effectors: G. Delespesse, et al.; Int. Arch. Allergy Immunol. 118, 384 (1999) Abstract
Functional expression of CD134 by neutrophils: R. Baumann, et al.; Eur. J. Immunol. 34, 2268 (2004) Abstract
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-522-043 Revised 24-Mar-06
CD134L, Soluble (mouse) (recombinant)
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SYNONYMS OX40L, Soluble (mouse) (recombinant)
TNFSF 4, Soluble (mouse) (recombinant)
CD252, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-043-C010   10 µg 200.00 USD Add To Cart
ALX-522-043-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~28kDa (under reducing conditions).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse CD134L (OX40L) (aa 52-198) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
SPECIFICITY: Binds to human and mouse CD134 (OX40).
BIOLOGICAL ACTIVITY: Activates T cell proliferation.
APPLICATION: Can be used together with anti-FLAG® MAb to detect membrane-bound mouse CD134 (OX40 ).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P43488: CD134L (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34: P.R. Baum, et al.; EMBO J. 13, 3992 (1994) Abstract
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
ALX-804-845 Revised 02-Apr-07
Monoclonal Antibody to CD134 (human) (Nicky-1)
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SYNONYMS anti-OX40 (human) MAb (Nicky-1)
anti-TNFRSF 4 (human) MAb (Nicky-1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-845-C100   100 µg 320.00 USD Add To Cart
ALX-804-845TD-T100 ATTO 488 100 tests 390.00 USD Add To Cart
ALX-804-845TS-T100 ATTO 647N 100 tests 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Nicky-1
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human CD134 (OX40) (aa 29-214) (Prod. No. ALX-522-022).
SPECIFICITY: Recognizes human CD134.
APPLICATION: Flow Cytometry
Immmunoprecipitation (1:200)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Product Images
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Product Description
New ATTO-fluorescent antibodies show increased photostability, outstanding brightness and intense signals. ATTO dyes are thermally stable, resistant to environmental changes and show no significant isomerization. ATTO 488 shows bright green fluorescence (λabs (max): 501nm, λem (max): 523nm, εmax: 90’000).
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes: E. Biagi, et al.; Blood 105, 2436 (2005) Abstract
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-804-138 Revised 14-Dec-06
Monoclonal Antibody to CD134L (mouse) (blocking) (MGP34)
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SYNONYMS anti-OX40L (mouse) MAb (blocking) (MGP34)
anti-TNFSF 4 (mouse) MAb (blocking) (MGP34)
anti-CD252 (mouse) MAb (blocking) (MGP34)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-138-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: MGP34
ISOTYPE: Rat IgG2c
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Rat cells stably overexpressing mouse CD134L (OX40L).
SPECIFICITY: Recognizes mouse CD134L. Does not cross-react with human CD134L.
APPLICATION: Flow Cytometry
Immunoprecipitation
Western Blot
Functional Application (blocks binding of CD134L to CD134)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand: K. Murata, et al.; J. Exp. Med. 191, 365 (2000) Abstract; Full Text
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-522-062 Revised 19-Oct-05
MegaOX40L [CD134L]™, Soluble (mouse) (recombinant)
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SYNONYMS OX40L [CD134L], Soluble (mouse) (recombinant):ACRP30headless (mouse) (FLAG®)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CD134 [OX40] & CD134L [OX40L] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-062-C010   10 µg 440.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~40kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse CD134L (OX40L) (aa 52-199) is fused at the N-terminus to mouse ACRP30 (aa 18-111) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water.
SPECIFICITY: Binds to human and mouse CD134 (OX40).
BIOLOGICAL ACTIVITY: Activates T cell proliferation.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored as recommended.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
CD Proteins • Recombinant Proteins / Fusion Proteins
 
 
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