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TNF & TNF Receptor Superfamily / Related Products
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ALX-804-207 Revised 13-Dec-04
Monoclonal Antibody to Osteoprotegerin (human) (NT) (OPG-13)
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SYNONYMS anti-OPG (human) MAb (NT) (OPG-13)
anti-TNFRSF 11B (human) MAb (OPG-13)
anti-Osteoclastogenesis Inhibitory Factor (human) MAb (NT) (OPG-13)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY OPG
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-207-C100   100 µg 508.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: OPG-13
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml after reconstitution.
FORMULATION: Lyophilized from sterile filtered solution of protein G affinity purified antibody in 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION: Reconstitute with 100µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN: Synthetic peptide corresponding to N-terminal aa 21-39 of human OPG (osteoprotegerin).
SPECIFICITY: Recognizes human OPG.
APPLICATION: ELISA
Western Blot (1:10'000).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
General Information
Osteoprotegerin (OPG) is a secretory glycoprotein belonging to TNF receptor superfamily. OPG consists of 401 aa with molecular weight of 55kDa as a monomer and 110kDa as a disulphide-linked dimer. It acts as a soluble factor in the regulation of bone mass and may be beneficial in the treatment of osteoporosis associated with increased osteoclast activity.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-532 Revised 15-Apr-08
Monoclonal Antibody to Osteoprotegerin (human) (OPG-01)
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SYNONYMS anti-OPG (human) MAb (OPG-01)
anti-TNFRSF 11B (human) MAb (OPG-01)
anti-Osteoclastogenesis Inhibitory Factor (human) MAb (OPG-01)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY OPG
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-532-C100   100 µg 508.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: OPG-01
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml after reconstitution.
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Lyophilized from sterile filtered solution in 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION: Reconstitute with 100µl distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN: Recombinant human OPG (osteoprotegerin).
SPECIFICITY: Recognizes human OPG.
APPLICATION: ELISA
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
General Information
Osteoprotegerin (OPG) is a secretory glycoprotein belonging to TNF receptor superfamily. OPG consists of 401 aa with molecular weight of 55kDa as a monomer and 110kDa as a disulfide-linked dimer. It acts as a soluble factor in the regulation of bone mass and may be beneficial in the treatment of osteoporosis associated with increased osteoclast activity.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-212 Revised 17-Sep-07
Monoclonal Antibody to RANK (human) (9A725)
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SYNONYMS anti-TRANCE-R (human) MAb (9A725)
anti-ODFR (human) MAb (9A725)
anti-TNFRSF 11A (human) MAb (9A725)
anti-CD265 (human) MAb (9A725)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY RANK & RANKL
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-212-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 9A725
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Recombinant human RANK (aa 326-616).
SPECIFICITY: Recognizes an epitope between aa 330-427 of human RANK. Detects a band of ~97kDa by Western blot.
APPLICATION: Flow Cytometry (intracellular) (see [1])
Immunohistochemistry (paraffin sections)
Western Blot  (1-2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
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Product Specific Literature References
[1] Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines: P. Fiumara, et al.; Blood 98, 2784 (2001) Abstract; Full Text
[2] A novel in vivo role for osteoprotegerin ligand in activation of monocyte effector function and inflammatory response: D. Seshasayee, et al.; J. Biol. Chem. 279, 30202 (2004) Abstract
[3] Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism: A.C. Bharti, et al.; J. Biol. Chem. 279, 6065 (2004) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-244 Revised 20-Aug-07
Monoclonal Antibody to RANKL (12A380)
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SYNONYMS anti-ODF MAb (12A380)
anti-OPGL MAb (12A380)
anti-TRANCE MAb (12A380)
anti-TNFSF 11 MAb (12A380)
anti-CD254 MAb (12A380)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY RANK & RANKL
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-244-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 12A380
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse RANKL (aa 1-317).
SPECIFICITY: Recognizes human and mouse RANKL. Detects a band of ~40kDa by Western blot.
APPLICATION: Flow Cytometry (see [2])
Immunohistochemistry (frozen sections (see [2]))
Western Blot (4-6µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at +4°C.
Product Specific Literature References
[1] Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines: P. Fiumara, et al.; Blood 98, 2784 (2001) Abstract; Full Text
[2] Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenesis: T. Yoneda, et al.; Endocrinology 145, 2384 (2004) Abstract; Full Text
[3] Expression of bone-regulatory proteins in human valve allografts: R. Shetty, et al.; Heart 92, 1303 (2006) Abstract; Full Text
General Information
RANKL (TRANCE, OPGL, ODF) is a member of the TNF family. RANKL (receptor activator of NF-κB [RANK] ligand) or TRANCE (TNF-related activation-induced cytokine receptor) has been implicated in interactions between T cells and dendritic cells [1,2]. RANKL binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival [2]. RANKL is also important in T- and B-cell maturation [3]. As OPGL (osteoprotegerin ligand) or ODF (osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis [4,5]. RANKL deficient mice show severe osteoporesis and complete abscence of osteoclasts as a result of lack of osteogenesis [3].
General Literature References
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function: D.M. Anderson, et al.; Nature 390, 175 (1997) Abstract
[2] TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor: B.R. Wong, et al.; J. Exp. Med. 186, 2075 (1997) Abstract; Full Text
[3] OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis: Y.Y. Kong, et al.; Nature 397, 315 (1999) Abstract
[4] Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation: D.L. Lacey, et al.; Cell 93, 165 (1998) Abstract
[5] Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand: H. Hsu, et al.; PNAS 96, 3540 (1999) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-243 Revised 13-May-08
Monoclonal Antibody to RANKL (12A668)
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SYNONYMS anti-ODF MAb (12A668)
anti-TRANCE MAb (12A668)
anti-OPGL MAb (12A668)
anti-TNFSF 11 MAb (12A668)
anti-CD254 MAb (12A668)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY RANK & RANKL
Ordering Information
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ALX-804-243-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 12A668
ISOTYPE: Mouse IgG1κ
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
IMMUNOGEN: Recombinant mouse RANKL (aa 1-317).
SPECIFICITY: Recognizes human and mouse RANKL. Detects a band of ~35-40kDa by Western blot.
APPLICATION: Immunohistochemistry (paraffin sections (5µg/ml))
Western Blot (1-2µg/ml)
Note: Not suitable for flow cytometry.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
Product Images
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Product Specific Literature References
Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression: R.N. Pearse, et al.; PNAS 98, 11581 (2001) Abstract; Full Text
Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines: P. Fiumara, et al.; Blood 98, 2784 (2001) Abstract; Full Text
Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors: T. Kikuchi, et al.; J. Immunol. 166, 3574 (2001) Abstract; Full Text
Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor: S. Niida, et al.; J. Biol. Chem. 279, 5752 (2004) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-830 Revised 16-Aug-07
Monoclonal Antibody to RANKL (human) (Ranky-1)
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SYNONYMS anti-ODF (human) MAb (Ranky-1)
anti-OPGL (human) MAb (Ranky-1)
anti-TRANCE (human) MAb (Ranky-1)
anti-TNFSF11 (human) MAb (Ranky-1)
anti-CD254 (human) MAb (Ranky-1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY RANK & RANKL
Ordering Information
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ALX-804-830-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: Ranky-1
ISOTYPE: Rat IgG1
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human soluble RANKL extracellular domain (aa 151-316) (Prod. No. ALX-522-012).
SPECIFICITY: Recognizes human RANKL.
APPLICATION: ELISA (capture)
Immunohistochemistry (paraffin sections)
Western Blot (1:1’000)
Note: Does not work for Flow Cytometry or Immunoprecipitation.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
Product Images
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General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling: S. Theoleyre, et al.; Cytokine Growth Factor Rev. 15, 457 (2004) Abstract
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-804-153 Revised 01-Sep-05
Monoclonal Antibody to TACI (human) (1A1)
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SYNONYMS anti-Transmembrane Activator and CAML Interactor (human) MAb (1A1)
anti-TNFRSF 13B (human) MAb (1A1)
anti-CD267 (human) MAb (1A1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TACI
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ALX-804-153-C050   50 µg 230.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 1A1
ISOTYPE: Rat IgG2a
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS.
IMMUNOGEN: Rat RBL cells expressing human TACI.
SPECIFICITY: Recognizes human TACI.
APPLICATION: Flow Cytometry
Note: Not recommended for Immunohistochemistry.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R Is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells: L.G. Ng, et al.; J. Immunol. 173, 807 (2004) Abstract
Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans: U. Salzer, et al.; Nat. Genet. 37, 820 (2005) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies • CD Antibodies
 
 
ALX-804-800 Revised 28-Mar-08
Monoclonal Antibody to TACI (mouse) (8F10)
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SYNONYMS anti-Transmembrane Activator and CAML Interactor (mouse) MAb (8F10)
anti-TNFRSF 13B (mouse) MAb (8F10)
anti-CD267 (mouse) MAb (8F10)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TACI
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-800-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 8F10
ISOTYPE: Rat IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS.
IMMUNOGEN: Rat RBL cells expressing mouse TACI.
SPECIFICITY: Recognizes mouse TACI.
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Functional Application (inhibition)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma: M. Batten, et al.; J. Immunol. 172, 812 (2004) Abstract
B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R Is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells: L.G. Ng, et al.; J. Immunol. 173, 807 (2004) Abstract
CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers: N.D. Huntington, et al.; Nat. Immunol. 7, 190 (2006) Abstract
TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo: Y. Diaz-de-Durana, et al.; Blood 107, 594 (2006 107, 594 (2006) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
CD Antibodies • Monoclonal Antibodies
 
 
ALX-804-859 Revised 26-Nov-07
Monoclonal Antibody to TL1A (Laety-1)
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SYNONYMS anti-TNFSF 15 MAb (Laety-1)
anti-VEGI MAb (Laety-1)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY HVEM & LIGHT / LT-betaR / DcR3 / Related Products
Ordering Information
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ALX-804-859-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: Laety-1
ISOTYPE: Mouse IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue cell culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human TL1A (Prod. No. ALX-522-084).
SPECIFICITY: Recognizes human and mouse TL1A.
APPLICATION: Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
TWEAK & FN14 / DR3 / Related Products • Monoclonal Antibodies
 
 
ALX-804-832 Revised 31-Oct-06
Monoclonal Antibody to TL1A (human) (L4G9)
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SYNONYMS anti-TNFSF 15 (human) MAb (L4G9)
anti-VEGI (human) MAb (L4G9)
PRODUCT LINE