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TNF & TNF Receptor Superfamily / Related Products
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ALX-804-250 Revised 18-Aug-08
Monoclonal Antibody to TRAF5 (human) (55A219)
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SYNONYMS anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 5 (human) MAb (55A219)
PRODUCT LINE Inflammation
PRODUCT CATEGORY TRAFs / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-250-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 55A219
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G affinity-purified.
FORMULATION: Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN: Recombinant human TRAF5 (tumor necrosis factor (TNF) receptor-associated factor 5) (aa 77-186).
SPECIFICITY: Recognizes human TRAF5. Detects a band of ~64kDa by Western blot.
APPLICATION: Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
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Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-296 Revised 09-Apr-08
Monoclonal Antibody to TRAIL (human) (2E5)
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SYNONYMS anti-Apo-2L (human) MAb (2E5)
anti-TNFSF 10 (human) MAb (2E5)
anti-CD253 (human) MAb (2E5)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-296-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 2E5
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified. Sterile filtered.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human soluble TRAIL (aa 95-281).
SPECIFICITY: Recognizes human TRAIL. Does not cross-react with mouse TRAIL.
APPLICATION: Flow Cytometry
Functional Application (excellent): neutralizes human TRAIL mediated killing in a concentration range of 0.5-1.5µg/ml. 
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors: M. Plasilova, et al.; Leukemia 16, 67 (2002) Abstract
IFN{alpha}-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity on leukemic cells: C. Tecchio, et al.; Blood 103, 3837 (2004) Abstract
Further Categories Containing This Product:
CD AntibodiesMonoclonal Antibodies
 
 
ALX-804-300 Revised 04-Mar-05
Monoclonal Antibody to TRAIL (human) (HS501)
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SYNONYMS anti-Apo-2L (human) MAb (HS501)
anti-TNFSF 10 (human) MAb (HS501)
anti-CD253 (human) MAb (HS501)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-300-C100   100 µg 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: HS501
ISOTYPE: Mouse IgG1
SOURCE/HOST: Purified from concentrate hybridoma tissue culture supernatant.
CONCENTRATION: 0.25mg/ml
PURITY: >95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing PEG-sucrose and 0.02% sodium azide.
IMMUNOGEN: Recombinant human soluble TRAIL.
SPECIFICITY: Recognizes human TRAIL.
APPLICATION: Western Blot (excellent)
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. Thaw at +37°C.
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Product Specific Literature References
TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus: B. Washburn, et al.; J. Immunol. 170, 1814 (2003) Abstract
Further Categories Containing This Product:
CD AntibodiesMonoclonal Antibodies
 
 
ALX-804-326 Revised 12-Jan-07
Monoclonal Antibody to TRAIL (human) (III6F)
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SYNONYMS anti-APO-2L (human) MAb (III6F)
anti-TNFSF 10 (human) MAb (III6F)
anti-CD253 (human) MAb (III6F)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-326-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: III6F
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE).
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human soluble TRAIL.
SPECIFICITY: Recognizes human TRAIL.
APPLICATION: ELISA
Flow Cytometry
Immunohistochemistry (frozen sections) (excellent)
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Development, characterization and use of monoclonal antibodies against sTRAIL: measurement of sTRAIL by ELISA: N.B. Liabakk, et al.; J. Immunol. Method. 259, 119 (2002) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
CD AntibodiesMonoclonal Antibodies
 
 
ALX-804-325 Revised 24-Mar-05
Monoclonal Antibody to TRAIL (human) (VI10E)
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SYNONYMS anti-Apo-2L (human) MAb (VI10E)
anti-TNFSF 10 (human) MAb (VI10E)
anti-CD253 (human) MAb (VI10E)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL [Apo-2L]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-325-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: VI10E
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE).
FORMULATION: Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human soluble TRAIL.
SPECIFICITY: Recognizes human TRAIL.
APPLICATION: ELISA (excellent)
Flow Cytometry
Immunoprecipitation
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored as recommended.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Development, characterization and use of monoclonal antibodies against sTRAIL: measurement of sTRAIL by ELISA: N.B. Liabakk, et al.; J. Immunol. Methods 259, 119 (2002) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
CD AntibodiesMonoclonal Antibodies
 
 
ALX-804-297 Revised 24-Jun-08
Monoclonal Antibody to TRAIL-R1 (human) (HS101)
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SYNONYMS anti-DR4 (human) MAb (HS101)
anti-TNFRSF 10A (human) MAb (HS101)
anti-CD261 (human) MAb (HS101)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL-R1
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-297-C100 Preservative Free 100 µg 330.00 USD Add To Cart
ALX-804-297A-C100 Purified 100 µg 330.00 USD Add To Cart
ALX-804-297F-T100 FITC 100 tests 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: HS101
ISOTYPE: Mouse IgG1
CONCENTRATION: HS101 & HS101 (preservative free): 1mg/ml
HS101-FITC: 0.5mg/ml
PURITY: ≥95%
FORMULATION: HS101: Liquid. In PBS containing 0.02% sodium azide.
HS101 (preservative free): Liquid. In PBS.
HS101-FITC: Liquid. 50µg in PBS containing 0.09% sodium azide.
IMMUNOGEN: Recombinant human TRAIL-R1 (DR4).
SPECIFICITY: Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4.
APPLICATION: Flow Cytometry
Immunocytochemistry
Immunoprecipitation

Functional Application: Inhibition (blocks TRAIL-R1 mediated killing if applied in solution).
For Western blot of whole cell lysate use PAb to TRAIL-R1 (CT) (Prod. No. PSC-1139).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8: M.R. Sprick, et al.; EMBO J. 21, 4520 (2002) Abstract
Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in Activated T Cells Abrogates TRAIL-Induced Apoptosis Upstream of the Mitochondrial Amplification Loop and Caspase-8: T.S. Soderstrom, et al.; J. Immunol. 169, 2851 (2002) Abstract
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation: M. Leverkus, et al.; Mol. Cell. Biol. 23, 777 (2003) Abstract; Full Text
TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus: B. Washburn, et al.; J. Immunol. 170, 1814 (2003) Abstract
TRAIL regulates normal erythroid maturation through an ERK-dependent pathway: P. Secchiero, et al.; Blood 103, 517 (2004) Abstract
IFN{alpha}-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity on leukemic cells: C. Tecchio, et al.; Blood 103, 3837 (2004) Abstract
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs: T.M. Ganten, et al.; Cell Death Differ. 11 Suppl 1, S86 (2004) Abstract
Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex: K. Izeradjene, et al.; Cancer Res. 64, 8036 (2004) Abstract; Full Text
cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes: T. Wachter, et al.; J. Biol. Chem. 279, 52824 (2004) Abstract; Full Text
Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression: E. Contassot, et al.; Blood 111, 4780 (2008) Abstract
Further Categories Containing This Product:
CD AntibodiesMonoclonal Antibodies
 
 
ALX-804-298 Revised 24-Jun-08
Monoclonal Antibody to TRAIL-R2 (human) (HS201)
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SYNONYMS anti-DR5 (human) MAb (HS201)
anti-KILLER (human) MAb (HS201)
anti-TNFRSF 10B (human) MAb (HS201)
anti-CD262 (human) MAb (HS201)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL-R2
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-298-C100 Preservative Free 100 µg 330.00 USD Add To Cart
ALX-804-298A-C100 Purified 100 µg 330.00 USD Add To Cart
ALX-804-298F-T100 FITC 100 tests 380.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: HS201
ISOTYPE: Mouse IgG1
CONCENTRATION: HS201 & HS201 (preservative free): 1mg/ml
HS201-FITC: 0.5mg/ml
FORMULATION: HS201: Liquid. In PBS containing 0.02% sodium azide.
HS201 (preservative free): Liquid. In PBS.
HS201-FITC: Liquid. 50µg in PBS containing 0.09% sodium azide.
IMMUNOGEN: Recombinant human TRAIL-R2 (DR5).
SPECIFICITY: Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.
APPLICATION: Flow Cytometry
Immunocytochemistry
Immunoprecipitation
Inhibition
Functional Application
: Inhibition (blocks TRAIL-R2 mediated killing if applied in solution).
For Western blot, use PAb to TRAIL-R2 (from goat) (Prod. No. ALX-210-743) or PAb to TRAIL-R2 (CT) (from rabbit) (Prod. No. PSC-2019).
LONG TERM STORAGE: -20°C
USE/STABILITY: HS201 & HS201 (preservative free): SHIPPED ON BLUE ICE.
HS201-FITC: SHIPPED ON DRY ICE.
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8: M.R. Sprick, et al.; EMBO J. 21, 4520 (2002) Abstract
Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in Activated T Cells Abrogates TRAIL-Induced Apoptosis Upstream of the Mitochondrial Amplification Loop and Caspase-8: T.S. Soderstrom, et al.; J. Immunol. 169, 2851 (2002) Abstract
Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis: H. Higuchi, et al.; J. Biol. Chem. 278, 454 (2003) Abstract; Full Text
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation: M. Leverkus, et al.; Mol. Cell. Biol. 23, 777 (2003) Abstract; Full Text
TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus: B. Washburn, et al.; J. Immunol. 170, 1814 (2003) Abstract
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs: T.M. Ganten, et al.; Cell Death Differ. 11 Suppl 1, S86 (2004) Abstract
Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex: K. Izeradjene, et al.; Cancer Res. 64, 8036 (2004) Abstract; Full Text
Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5: T.G. Jin, et al.; J. Biol. Chem. 279, 55594 (2004) Abstract; Full Text
TRAIL regulates normal erythroid maturation through an ERK-dependent pathway: P. Secchiero, et al.; Blood 103, 517 (2004) Abstract
IFN{alpha}-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity on leukemic cells: C. Tecchio, et al.; Blood 103, 3837 (2004) Abstract
cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes: T. Wachter, et al.; J. Biol. Chem. 279, 52824 (2004) Abstract; Full Text
Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression: E. Contassot, et al.; Blood 111, 4780 (2008) Abstract
Further Categories Containing This Product:
CD AntibodiesMonoclonal Antibodies
 
 
ALX-804-344 Revised 24-Jun-08
Monoclonal Antibody to TRAIL-R3 (human) (HS301)
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SYNONYMS anti-DcR1 (human) MAb (HS301)
anti-TRID (human) MAb (HS301)
anti-TNFRSF 10C (human) MAb (HS301)
anti-CD263 (human) MAb (HS301)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY TRAIL-R3
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-344A-C100   100 µg 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: HS301
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.5mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Recombinant human TRAIL-R3 (DcR1).
SPECIFICITY: Recognizes human TRAIL-R3. Does not cross-react with human TRAIL-R1, -R2 or -R4.
APPLICATION: Flow Cytometry
Immunocytochemisty
For Western blot of whole cell lysate, use PAb to TRAIL-R3 (human) (from goat) (Prod. No. ALX-210-744).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus: B. Washburn, et al.; J. Immunol. 170, 1814 (2003) Abstract
TRAIL regulates normal erythroid maturation through an ERK-dependent pathway: P. Secchiero, et al.; Blood 103, 517 (2004) Abstract
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs: T.M. Ganten, et al.; Cell Death Differ. 11 Suppl 1, S86 (2004) Abstract
cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes: T. Wachter, et al.; J. Biol. Chem. 279, 52824 (2004) Abstract; Full Text
Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression: E. Contassot, et al.; Blood 111, 4780 (2008) Abstract
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