ALEXIS Biochemicals: TRAP5 (human) ImmunoCapture Enzyme-Activity Assay Kit

ALX-850-300

Revised 02-Nov-06

TRAP5 (human) ImmunoCapture Enzyme-Activity Assay Kit
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	TRAP5 [TRACP]

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-850-300-KI01		1 Kit	852.00 USD

Product Specification

SENSITIVITY:	0.2-0.4U of TRAP5/l
QUANTITY:	96 wells (25µl/well).
APPLICATION:	For the quantitative determination of TRAP5 in serum and EDTA plasma. The kit measures only the TRAP5 proteins exhibiting enzymatic activity. Total assay time is less than four hours.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C

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General Information

TRAP5b is claimed to be a specific marker of bone resorption [2-4]. Both osteopontin and bone sialoprotein are colocalized with TRAP5 in the resorption lacuna of osteoclasts and dephosphorylation of osteopontin impair its ability to promote adhesion as well as migration of osteoclasts in vitro [5].
MANUFACTURER	Manufactured by BioVendor.

General Literature References

[1] Purification and N-terminal sequence of two tartrate-resistant acid phosphatases type-5 from the hairy cell leukemia spleen: J.J. Stepan, et al.; BBRC 165, 1027 (1989) Abstract
[2] Tartrate-resistant acid phosphatase 5b: a novel serum marker of bone resorption: J.M. Halleen, et al.; J. Bone Miner. Res 15, 1337 (2000) Abstract
[3] Tartrate-resistant acid phosphatase isoform 5b as serum marker for osteoclastic activity: A.J. Janckila, et al.; Clin. Chem. 47, 74 (2001) Abstract
[4] Clinical performance of immunoreactive tartrate-resistant acid phosphatase isoform 5b as a marker of bone resorption: R.A. Hannon, et al.; Bone 34, 187 (2001) Abstract
[5] TRACP as an osteopontin phosphatase: G. Andersson, et al.; J. Bone Miner. Res 18, 1912 (2003) Abstract

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