ALEXIS Biochemicals: Tautomycin

ALX-380-041

Revised 08-Aug-08

Tautomycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-041-C025		25 µg	180.00 USD
ALX-380-041-C050		50 µg	235.00 USD
ALX-380-041-C100		100 µg	440.00 USD

Product Specification

FORMULA:	C₄₁H₆₆O₁₃
MW:	767.0
CAS NUMBER:	109946-35-2
RTECS:	WX1000000
SOURCE/HOST:	Isolated from Streptomyces spiroverticillatus.
PURITY:	≥90% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol, ethyl acetate or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light and moisture.
HAZARD:	VERY TOXIC.

Product Description

Cell permeable, potent protein phosphatase inhibitor. Apoptosis inducer. Mixture of two isomers.

Product Specific Literature References

A new antibiotic, tautomycin: X.C. Cheng, et al.; J. Antibiot. (Tokyo) 40, 907 (1987) Abstract
Comparison of the effect of tautomycin and phorbol ester on protein kinase C in a cell-free system: J. Magae, et al.; J. Antibiot. 42, 1290 (1989) Abstract
Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A: C. MacKintosh & S. Klumpp; FEBS Lett. 277, 137 (1990) Abstract
Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle: M.C. Gong, et al.; J. Biol. Chem. 267, 14662 (1992) Abstract; Full Text
Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity: M. Suganuma, et al.; Toxicon 30, 873 (1992) Abstract
Molecular shape analysis and activity of tautomycin, a protein phosphatase inhibitor: Y. Sugiyama, et al.; Bioorg. Med. Chem. Lett. 6, 3 (1996)
The apoptosis-inducing activity of the two protein phosphatase inhibitors, tautomycin and thyrsiferyl 23-acetate, is not due to the inhibition of protein phosphatases PP1 and PP2A: K. Kikuchi, et al.; Int. J. Mol. Med. 4, 395 (1999), Review Abstract

Further Categories Containing This Product:

Protein Serine / Threonine Phosphatases Other Products • Antibiotics - Apoptosis Inducers & Inhibitors

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