ALEXIS Biochemicals: Teniposide

ALX-400-053

Revised 21-Apr-08

Teniposide
SYNONYMS	(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3’,4’:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one 4’-Demethylepipodophyllotoxin-β-D-thenylidine glucoside
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Agents (DNA Interaction & Gene Regulation)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-053-M025		25 mg	55.00 USD
ALX-400-053-M100		100 mg	165.00 USD

Product Specification

FORMULA:	C₃₂H₃₂O₁₃S
MW:	656.7
CAS NUMBER:	29767-20-2
MERCK INDEX:	14: 9145
SOURCE/HOST:	Semisynthetic derivative of podophyllotoxin.
PURITY:	≥97% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in acetone or dimethyl formamide; slightly soluble in methanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC. MAY BE CARCINOGENIC.

Product Description

Glycoside-derivative of podophyllotoxin. Has cytostatic effect. Inhibits topoisomerase II. Induces apoptosis.

Product Specific Literature References

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage: W. Ross, et al.; Cancer Res. 44, 5857 (1984) Abstract; Full Text
Human cytochrome P450 metabolism of teniposide and etoposide: M.V. Relling, et al.; J. Pharmacol. Exp. Ther. 261, 491 (1992) Abstract
Topoisomerase II as a target of VM-26 and 4’-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells: S de Jong, et al.; Cancer Res. 53, 1064 (1993) Abstract; Full Text
Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma: J. Li, et al.; World J. Surg. Oncol. 4, 41 (2006) Abstract; Full Text