ALEXIS Biochemicals: Toll-like Receptor 4 (mouse):Fc (human) (recombinant) (aa 24-334)

ALX-522-073

Revised 20-Sep-07

Toll-like Receptor 4 (mouse):Fc (human) (recombinant) (aa 24-334)
SYNONYMS	TLR4 (mouse):Fc (human) (recombinant) (aa 24-334) CD284 (mouse):Fc (human) (recombinant) (aa 24-334)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLRs

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-073-C050		50 µg	360.00 USD

Product Specification

MW:	~83kDa (SDS-PAGE).
SOURCE/HOST:	Produced in HEK 293 cells. The N-terminal region of the extracellular domain of mouse TLR4 (aa 24-334) is fused at the C-terminus to the Fc portion of human IgG1 and a linker peptide (2 aa).
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Product Specific Literature References

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy: L. Apetoh, et al.; Nat. Med. 13, 1050 (2007) Abstract

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region: A. Poltorak, et al.; Blood Cells Mol. Dis. 24, 340 (1998) Abstract
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene: A. Poltorak, et al.; Science 282, 2085 (1998) Abstract
Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction: J.C. Chow, et al.; J. Biol. Chem. 274, 10689 (1999) Abstract; Full Text
TLR4 as the mammalian endotoxin sensor: B. Beutler; Curr. Top. Microbiol. Immunol. 270, 109 (2002), (Review) Abstract