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ALX-380-303 Revised 15-Apr-08 New product
Tosufloxacin . tosylate
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SYNONYMS 7-(3-Amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid . tosylate
A-64730
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-303-M250   250 mg 90.00 USD Add To Cart
ALX-380-303-G001   1 g 270.00 USD Add To Cart
Product Specification
FORMULA: C19H15F3N4O3 . C7H8O3S
MW: 404.4 . 172.2
CAS NUMBER: 115964-29-9
MERCK INDEX: 14: 9555
PURITY: ≥98% (Assay)
APPEARANCE: White to yellow crystalline solid.
SOLUBILITY: Slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Gram-positive and Gram-negative aerobic bacteria, anaerobic bacteria and Chlamydia trachomatis.
Product Specific Literature References
In vitro activity of tosufloxacin, a new quinolone, against respiratory pathogens derived from cystic fibrosis sputum: A.G. Arguedas, et al.; Antimicrob. Agents Chemother. 34, 2223 (1990) Abstract; Full Text
Synthesis and biological properties of A-71497: a prodrug of tosufloxacin: D.T. Chu, et al.; Drugs Exp. Clin. Res. 16, 435 (1990) Abstract
The in-vitro activity of tosufloxacin, a new fluorinated quinolone, compared with that of ciprofloxacin and temafloxacin: A. King, et al.; J. Antimicrob. Chemother. 28, 719 (1991) Abstract
In-vitro activity of tosufloxacin, a new quinolone antibacterial agent: M.A. Cooper, et al.; J. Antimicrob. Chemother. 29, 639 (1992) Abstract
Stereoselective analysis of the disposition of tosufloxacin enantiomers in man: R. Minami, et al.; Eur. J. Clin. Pharmacol. 45, 489 (1993) Abstract
Antibacterial activities of tosufloxacin against anaerobic bacteria and the electron micrograph of its bactericidal effects: M. Takahata & T. Nishino; Chemotherapy 43, 153 (1997) Abstract
Clinical assessment of tosufloxacin tosilate: S. Kohno; J. Infect. Chemother. 8, 19 (2002), (Review) Abstract
Tosufloxacin tosilate-induced thrombocytopenic purpura: H. Takahama & H. Tazaki; J. Dermatol. 34, 465 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Topoisomerase Inhibitors • Antibiotics - DNA Replication Inhibitors
 
 
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