ALEXIS Biochemicals: Tranilast

ALX-550-409

Revised 18-May-06

Tranilast
SYNONYMS	N-(3’,4’-Dimethoxycinnamoyl)anthranilic acid
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Anti-inflammatory Agents Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-409-M010		10 mg	70.00 USD
ALX-550-409-M050		50 mg	280.00 USD

Product Specification

FORMULA:	C₁₈H₁₇NO₅
MW:	327.3
CAS NUMBER:	53902-12-8
MERCK INDEX:	14: 9570
RTECS:	DG8731000
PURITY:	≥95% (HPLC)
APPEARANCE:	Off-white to yellow solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL.

Product Description

Anti-inflammatory and anti-angiogenic agent. Exerts its effects by inhibiting the expression of mediators such as MCP-1, TGF-β, TNF-α induced vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1) and E-selectin.

Product Specific Literature References

Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages: H. Suzawa, et al.; Jpn. J. Pharmacol. 60, 85 (1992) Abstract
Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts: H. Yamada, et al.; J. Biochem. 116, 892 (1994) Abstract
Tranilast inhibits interleukin-1beta-induced monocyte chemoattractant protein-1 expression in rat mesangial cells: A. Chikaraishi, et al.; Eur. J. Pharmacol. 427, 151 (2001) Abstract
Tranilast inhibits cytokine-induced nuclear factor kappaB activation in vascular endothelial cells: M. Spiecker, et al.; Mol. Pharmacol. 62, 856 (2002) Abstract; Full Text
Tranilast: a novel weapon against insulin resistance: M.R. Namazi & J. Soma; Med. Hypotheses 64, 1135 (2005) Abstract

Further Categories Containing This Product:

Antitumor Reagents Other Products • Angiogenesis Modulators Other Products

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