ALEXIS Biochemicals: Trequinsin . hydrochloride

ALX-270-126

Revised 13-Dec-04

Trequinsin . hydrochloride
SYNONYMS	9,10-Dimethoxy-2-mesitylimino-3-methyl-2,3,6,7-tetrahydro-4H-pyrimido-[6,1a]-isoquinolin-4-one . HCl HL 725 . HCl
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphodiesterases / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-126-M010		10 mg	290.00 USD

Product Specification

FORMULA:	C₂₄H₂₇N₃O₃ . HCl
MW:	405.5 . 36.5
CAS NUMBER:	79855-88-2
PURITY:	≥98%
APPEARANCE:	White to pale yellow solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
USE/STABILITY:	Solutions are stable for up to 3 months when stored at -20°C.
HANDLING:	Protect from moisture.

Product Description

Ultrapotent, highly selective inhibitor of cGMP-inhibited phosphodiesterase (PDE lll) in vitro. Potentiates adenosine-stimulated cAMP accumulation.

Product Specific Literature References

HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro: D. Rupert & K.U. Weithmann; Life Sci. 31, 2037 (1982) Abstract
Arachidonic acid metabolites, ADP and thrombin modulate occlusive thrombus formation over extensive arterial injury in the rat: F. DeClerck, et al.; Blood Coag. Fibrinol. 1, 247 (1990) Abstract
Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C- mediated pathways: B.A. Konkle, et al.; J. Biol. Chem. 265, 21867 (1990) Abstract; Full Text
Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells: M.E. Whalin, et al.; Mol. Pharmacol. 39, 711 (1991) Abstract

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