ALEXIS Biochemicals: Triacsin C

ALX-380-285

Revised 16-Sep-08

Triacsin C
SYNONYMS	2,4,7-Undecatrienal nitrosohydrazone WS1228A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-285-MC05		0.5 mg	190.00 USD
ALX-380-285-M001		1 mg	350.00 USD

Product Specification

FORMULA:	C₁₁H₁₇N₃O
MW:	207.3
CAS NUMBER:	76896-80-5
SOURCE/HOST:	Isolated from Streptomyces aureofaciens.
PURITY:	≥94% (HPLC)
APPEARANCE:	White to light brown powder.
SOLUBILITY:	Soluble in DMSO (10mg/ml) or methanol (5mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep under inert gas. Protect from light.
MELTINGPOINT:	102-103°C

Product Description

Analog of polyunsaturated fatty acid. Potent inhibitor of long-chain fatty acyl CoA synthetase. Selectively inhibits arachidonoyl-CoA synthetase in intact cells. Blocks β-cell apoptosis induced by fatty acids (lipoapoptosis) and synthesis of triglycerides, diglycerides and cholesterol esters. Potent vasodilator. Used in a rat model of obesity.

Product Specific Literature References

Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase: E.J. Hartman, et al.; Prostaglandins 37, 655 (1989) Abstract
Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation: H. Tomoda, et al.; J. Biol. Chem. 266, 4214 (1991) Abstract; Full Text
The acyl-CoA synthetase inhibitor triacsin C enhanced eicosanoid release in leukocytes: S. Oh-ishi, et al.; Jpn. J. Pharmacol. 59, 417 (1992) Abstract; Full Text
Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA: R.A. Igal, et al.; Biochem. J. 324, 529 (1997) Abstract; Full Text
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression: M. Shimabukuro, et al.; PNAS 95, 9558 (1998) Abstract; Full Text
Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C: I. Namatame, et al.; J. Biochem. 125, 319 (1999) Abstract
Triacsin C inhibits the formation of 1H NMR-visible mobile lipids and lipid bodies in HuT 78 apoptotic cells: E. Iorio, et al.; Biochim. Biophys. Acta 1634, 1 (2003) Abstract
ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells: Y. Masuda, et al.; J. Lipid Res. 47, 87 (2006) Abstract; Full Text

Further Categories Containing This Product:

Lipid Metabolism Other Products

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.