ALEXIS Biochemicals: Tryptanthrin

ALX-270-360

Revised 21-May-08

Tryptanthrin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products for Inflammation Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-360-M001		1 mg	50.00 USD
ALX-270-360-M005		5 mg	200.00 USD

Product Specification

FORMULA:	C₁₅H₈N₂O₂
MW:	248.2
CAS NUMBER:	13220-57-0
SOURCE/HOST:	Synthetic.
PURITY:	≥98% (¹H-NMR, HPLC)
APPEARANCE:	Yellow needles.
SOLUBILITY:	Soluble in DMSO (8mg/ml) or methanol (0.3mg/ml); sparingly soluble in water (2.5µg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least 2 years after receipt when stored at +4°C in the dark. Stock solutions made in DMSO must be stored in the dark no longer than one month.
HANDLING:	Protect from light and moisture.
IDENTITY:	Identity determined by ¹H-NMR, ¹³C-NMR, IR, MS and UV.

Product Description

Potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Selective inhibitor of cyclooxygenase 2 (COX-2). Inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Inhibits the production of IFN-γ and IL-2 after stimulation of Peyer’s patch lymphocytes with staphylococcal enterotoxin B (SEB). Inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin (Prod. No. ALX-380-042) resistance on breast cancer cells.

Product Specific Literature References

H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000)
Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med. 67, 411 (2001) Abstract
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis: H. Danz, et al.; Planta Med. 68, 875 (2002) Abstract
Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages: T. Ishihara, et al.; Eur. J. Pharmacol. 407, 197 (2000) Abstract
Tryptanthrin inhibits interferon-gamma production by Peyer’s patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin: Y. Takei, et al.; Biol. Pharm. Bull. 26, 365 (2003) Abstract
Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells: S.T. Yu, et al.; BBRC 358, 79 (2007) Abstract

General Information

Tryptanthrin occurs as a natural product in various plants, including Isatis tinctoria, I. indigotica, Polygonum tinctorium, Couroupita guianensis, Wrightia tinctoria and Calanthe discolor.

Further Categories Containing This Product:

Leukotrienes Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • Prostaglandins Other Products • COX Inhibitors • Natural Products - Nitric Oxide Pathway Modulators

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