ALEXIS Biochemicals: Tunicamycin

ALX-380-047

Revised 20-Feb-08

Tunicamycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-047-M010		10 mg	82.00 USD
ALX-380-047-M050		50 mg	350.00 USD

Product Specification

CAS NUMBER:	11089-65-9
MERCK INDEX:	14: 9819
RTECS:	YO7980200
SOURCE/HOST:	Isolated from Streptomyces lysosuperficus.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
PURITY DETAIL:	Mixture of tunicamycin A, B, C and D.
SOLUBILITY:	Soluble in methanol or DMSO (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	VERY TOXIC.

Product Description

Nucleoside antibiotic that blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. Induces ER-stress following the inhibition of N-linked glycosylation.

Product Specific Literature References

Isolation and structures of components of Tunicamycin: T. Ito, et al.; Agric. Biol. Chem. 44, 695 (1980)
Separation of tunicamycin homologues by reversed-phase high-performance liquid chromatography: W.C. Mahoney & D. Duksin; J. Chromatogr. 198, 506 (1980) Abstract
Relationship of the structure and biological activity of the natural homologues of tunicamycin: D. Duksin & W.C. Mahoney; J. Biol. Chem. 257, 3105 (1982) Abstract; Full Text
Tunicamycin inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells: A. Tordai, et al.; BBRC 206, 857 (1995) Abstract
Tunicamycin, a new antibiotic. I. Isolation and characterization of tunicamycin: A. Takatsuki, et al.; J. Antibiot. (Tokyo) 24, 215 (1971) Abstract
Tunicamycin inhibits NMDA and AMPA receptor responses independently of N-glycosylation: K. Maruo, et al.; Brain Res. 977, 294 (2003) Abstract
Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells: T. Shiraishi, et al.; Cancer Res. 65, 6364 (2005) Abstract
Novel potential of tunicamycin as an activator of the aryl hydrocarbon receptor -- dioxin responsive element signaling pathway: K. Horikawa, et al.; FEBS Lett. 580, 3721 (2006) Abstract
Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response: C.C. Jiang, et al.; Cancer Res. 67, 5880 (2007) Abstract
Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin: T. Yoshida, et al.; Oncol. Rep. 18, 1239 (2007) Abstract

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Endoplasmatic Reticulum Stress • Autophagy Other Products

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