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ALX-350-154 Revised 08-May-08
Tylophorine
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SYNONYMS (-)-R-Tylophorine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-154-MC05   0.5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C24H27NO4
MW: 393.5
CAS NUMBER: 111408-21-0
MERCK INDEX: 14: 9831
SOURCE/HOST: Isolated from Tylophora indica.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Phenanthroindolizidine alkaloid which shows antitumor activity. Exhibits potent suppression of inducible nitric oxide synthase (iNOS; NOS II) and cyclooxygenase-2 (COX-2). Enhances the phosphorylation of Akt (protein kinase B; PKB) and thus decreases the expression and phosphorylation levels of c-Jun protein, thereby causing the subsequent inhibition of AP1 activity. Exerts anti-inflammatory effects. Adenylyl cyclase modulator. For the biogenetic precursor see septicine (Prod. No. ALX-350-159)
Product Specific Literature References
Pharmacological investigations of tylophorine, the major alkaloid of Tylophora indica: C. Gopalakrishnan, et al.; Indian J. Med. Res. 69, 513 (1979) Abstract
Effect of tylophorine, a major alkaloid of Tylophora indica, on immunopathological and inflammatory reactions: C. Gopalakrishnan, et al.; Indian J. Med. Res. 71, 940 (1980) Abstract
The responsiveness of leukocyte adenyl cyclase to tylophorine in asthmatic subjects: V. Raina & S. Raina; BBRC 94, 1074 (1980) Abstract
Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: Asymmetric Synthesis of (-)-Septicine and (-)-Tylophorine: D.L. Comins, et al.; J. Org. Chem. 62, 7435 (1997) Abstract
Novel mode of action of tylophorine analogs as antitumor compounds: W. Gao, et al.; Cancer Res. 64, 678 (2004) Abstract; Full Text
Anti-inflammatory mechanisms of phenanthroindolizidine alkaloids: C.W. Yang, et al.; Mol. Pharmacol. 69, 749 (2006) Abstract; Full Text
Total syntheses of the tylophora alkaloids cryptopleurine, (-)-antofine, (-)-tylophorine, and (-)-ficuseptine C: A. Fürstner & J.W. Kennedy; Chemistry 12, 7398 (2006) Abstract
Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents: L. Wei, et al.; Bioorg. Med. Chem. 14, 6560 (2006) Abstract
Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents: L. Wei, et al.; J. Med. Chem. 50, 3674 (2007) Abstract
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Further Categories Containing This Product:
Natural Products - Anti-inflammatory AgentsAlkaloidsAdenylyl Cyclases Other Products
 
 

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