ALEXIS Biochemicals: Tyrphostin AG 494

ALX-270-143

Revised 20-Feb-08

Tyrphostin AG 494
SYNONYMS	Tyrphostin B48 N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide α-Cyano-(3,4-dihydroxy)-N-phenylcinnamamide
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Tyrphostins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-143-M005		5 mg	25.00 USD
ALX-270-143-M025		25 mg	90.00 USD

Product Specification

FORMULA:	C₁₆H₁₂N₂O₃
MW:	280.3
CAS NUMBER:	133550-35-3
PURITY:	≥98%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Blocks CDK2 activation and causes cells to arrest at late G1 and during S phase.

Product Specific Literature References

Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases: A. Gazit, et al.; J. Med. Chem. 34, 1896 (1991) Abstract
Tyrphostin AG 494 blocks Cdk2 activation: N. Osherov & A. Levitzki; FEBS Lett. 410, 187 (1997) Abstract
Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase: N. Kleinberger-Doron, et al.; Exp. Cell Res. 241, 340 (1998) Abstract

Further Categories Containing This Product:

EGFR Kinase Inhibitors • Tyrosine Kinase Inhibitors • CDK & Cyclin Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.