ALEXIS Biochemicals: URB602

ALX-550-519

Revised 03-Jul-07

URB602
SYNONYMS	[1,1’-Biphenyl]-3-yl-carbamic acid cyclohexyl ester
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Diacylglycerol Lipase [DAGL] & Monoacylglycerol Lipase [MGL]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-519-M005		5 mg	34.00 USD
ALX-550-519-M025		25 mg	150.00 USD

Product Specification

FORMULA:	C₁₉H₂₁NO₂
MW:	295.4
CAS NUMBER:	565460-15-3
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 100% ethanol (10mg/ml), DMSO (30mg/ml) or dimethyl formamide (30mg/ml); also soluble in a 1:1 solution in DMSO:PBS, pH 7.2 (0.25mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Sparingly soluble in aqueous buffers. For maximum solubility dissolve first in DMSO and then dilute with the aqeous buffer of choice. We do not recommend storing the aqueous solution for more than one day.

Product Description

Selective noncompetitive inhibitor of monoacylglycerol lipase (MGL) (IC₅₀=28µM). Does not inhibit FAAH, DAG lipase or COX-2.

Product Specific Literature References

An endocannabinoid mechanism for stress-induced analgesia: A.G. Hohmann, et al.; Nature 435, 1108 (2005) Abstract
Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla: R.L. Suplita, 2nd, et al.; Neuropharmacology 49, 1201 (2005) Abstract

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