ALEXIS Biochemicals: URB754

ALX-550-410

Revised 01-Jun-06

URB754
SYNONYMS	6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Diacylglycerol Lipase [DAGL] & Monoacylglycerol Lipase [MGL]/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-410-M001		1 mg	15.00 USD
ALX-550-410-M005		5 mg	25.00 USD
ALX-550-410-M025		25 mg	100.00 USD

Product Specification

FORMULA:	C₁₆H₁₄N₂O₂
MW:	266.3
CAS NUMBER:	86672-58-4
PURITY:	≥98%
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in DMSO and dimethyl formamide. Also soluble in aqueous solutions.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 2 years when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:	Protect from light.

Product Description

Potent, noncompetitive inhibitor of monoacylglycerol lipase (MGL), which hydrolyzes 2-arachidonoylglycerol (2-AG) to arachidonic acid and glycerol. IC₅₀=200nM for the recombinant rat brain enzyme. Inhibits rat brain fatty acid amide hydrolase (FAAH) less effectively (IC₅₀=32µM) and binds weakly to the rat CB₁ receptor (IC₅₀=3.8µM).

Product Specific Literature References

Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus: J.K. Makara, et al.; Nat. Neurosci. 8, 1139 (2005) Abstract