ALEXIS Biochemicals: Valinomycin

ALX-450-012

Revised 24-Oct-07

Valinomycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Ionophores

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-450-012-M005		5 mg	20.00 USD
ALX-450-012-M025		25 mg	60.00 USD

Product Specification

FORMULA:	C₅₄H₉₀N₆O₁₈
MW:	1111.4
CAS NUMBER:	2001-95-8
MERCK INDEX:	14: 9910
SOURCE/HOST:	Isolated from Streptomyces fulvissimus.
PURITY:	≥90%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in acetic acid, chloroform, DMSO or ether.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	TOXIC.

Product Description

Potassium ionophore. Useful reagent for the measurement of K+ ions by electrode-based systems. Induces apoptosis in several cell lines.

Product Specific Literature References

Opposing interactions of ionophores (valinomycin and monensin) on calcium ion uptake in rat retinal preparations: J.B. Lombardini; Neurochem. Res. 10, 77 (1985) Abstract
Valinomycin-based K+ selective microelectrodes with low electrical membrane resistance: D. Ammann, et al.; Neurosci. Lett. 74, 221 (1987) Abstract
Alternative pathways of apoptosis induced by methylprednisolone and valinomycin analyzed by flow cytometry: C.L. Deckers, et al.; Exp. Cell. Res. 208, 362 (1993) Abstract
K+ ionophores inhibit nerve growth factor-induced neuronal differentiation in rat adrenal pheochromocytoma PC12 cells: H.Harada, et al.; Biochim. Biophys. Acta 1220, 310 (1994) Abstract
The effect of respiration on the permeability of the mitochondrial membrane to ions: S. Luvisetto, et al.; Biochim. Biophys. Acta 1186, 12 (1994) Abstract
Combination of the electrogenic ionophores, valinomycin and CCCP, can lead to non-electrogenic K+/H+ exchange on bilayer lipid membranes: V.N. Orlov, et al.; FEBS Lett. 345, 104 (1994) Abstract
Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential: Y. Inai, et al.; Cell Struct. Funct. 22, 555 (1997) Abstract
Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification: I.J. Furlong, et al.; Cell Death Differ 5, 214 (1998) Abstract
Valinomycin-induced apoptosis of human NK cells is predominantly caspase independent: A. Paananen, et al.; Toxicology 212, 37 (2005) Abstract

Further Categories Containing This Product:

Antibiotics - Apoptosis Inducers & Inhibitors

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