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ALX-550-304 Revised 12-Aug-08
Valproic acid . sodium salt
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SYNONYMS 2-Propylpentanoic acid . Na
Sodium 2-propylpentanoate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuroactive Agents Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-304-G005   5 g 25.00 USD Add To Cart
Product Specification
FORMULA: C8H15O2 . Na
MW: 143.2 . 23.0
CAS NUMBER: 1069-66-5
MERCK INDEX: 14: 9913
PURITY: ≥98% (Assay)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (50mg/ml) or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Hygroscopic.

Product Description
Anticonvulsant [1,2]. Anti-depressant [3,4]. Potent teratogen [5]. Inhibits histone deacetylase 1 (HDAC1) (IC50=0.4mM) [6,7]. Inhibitor of human cytochrome P450 2C9 isoform (Ki=600µM) [8]. Inducer of apoptosis in human leukemia cells [9]. In nude mice experiments, inhibits significantly human uterine tumor growth without toxic side effects [10].
Product Specific Literature References
[1] Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy: R.M. Pinder, et al.; Drugs 13, 81 (1977), (Review) Abstract
[2] The mechanism of action of sodium valproate: R.W. Kerwin & P.V. Taberner; Gen. Pharmacol. 12, 71 (1981), (Review) Abstract
[3] Actions of sodium valproate on the central nervous system: G. Tunnicliff; J. Physiol. Pharmacol. 50, 347 (1999), (Review) Abstract
[4] Mechanisms of action of valproate: a commentatory: C.U. Johannessen; Neurochem. Int. 37, 103 (2000), (Review) Abstract
[5] Maternal valproic acid and congenital neural tube defects: E. Robert & P. Guibaud; Lancet 2, 937 (1982) Abstract
[6] Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen: C.J. Phiel, et al.; J. Biol. Chem. 276, 36734 (2001) Abstract; Full Text
[7] Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells: M. Gottlicher, et al.; Embo J. 20, 6969 (2001) Abstract
[8] In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9): X. Wen, et al.; Br. J. Clin. Pharmacol. 52, 547 (2001) Abstract
[9] Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathways: R. Kawagoe, et al.; Leuk. Res. 26, 495 (2002) Abstract
[10] Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells: N. Takai, et al.; Clin. Cancer Res. 10, 1141 (2004) Abstract
[11] Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1: S. Shetty, et al.; Mol. Cell. Biol. 25, 5404 (2005) Abstract; Full Text
Further Categories Containing This Product:
HDAC Inhibitors • Apoptosis Inducers & Inhibitors Other Products • Cytochrome P450 [CYP450]/Related Products • Autophagy Other Products
 
 
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