ALEXIS Biochemicals: Venturicidin B

ALX-380-223

Revised 19-Feb-08

Venturicidin B
SYNONYMS	Aabomycin A2
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Antifungal

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-223-MC25		0.25 mg	360.00 USD

Product Specification

FORMULA:	C₄₀H₆₆O₁₀
MW:	706.9
CAS NUMBER:	33538-72-6
MERCK INDEX:	14: 9947
SOURCE/HOST:	Isolated from Streptomyces sp. MST-117594.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Macrolide antibiotic. Potent inhibitor of mitochondrial ATP synthase complex, acting on the F₀ membrane sector. Shows antifungal activity.

Product Specific Literature References

Venturicidin: a new antifungal antibiotic of potential use in agriculture: A. Rhodes, et al.; Nature 192, 952 (1961) Abstract
Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin: D.S. Perlin, et al.; Biochim. Biophys. Acta 807, 238 (1985) Abstract
Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance: M. Galanis, et al.; FEBS Lett. 249, 333 (1989) Abstract; Full Text
Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds: A. Matsuno-Yagi and Y. Hatefi; J. Biol. Chem. 268, 6158 (1993) Abstract; Full Text
Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers: H. Miedema, et al.; BBRC 203, 1005 (1994) Abstract

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