ALEXIS Biochemicals: Veratridine

ALX-550-307

Revised 25-Mar-08

Veratridine
SYNONYMS	3-Veratroylveracevine
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Na+ Channels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-307-M005		5 mg	80.00 USD
ALX-550-307-M025		25 mg	320.00 USD

Product Specification

FORMULA:	C₃₆H₅₁NO₁₁
MW:	673.8
CAS NUMBER:	71-62-5
MERCK INDEX:	14: 9954
RTECS:	YX5600000
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 100% ethanol or DMSO (25mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	VERY TOXIC.

Product Description

Activates Na⁺ channels. Increases intracellular Ca²⁺ levels without affecting Na⁺-Ca²⁺ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na⁺ channels causing persistent activation. Induces cell death in bovine chromaffin cells.

Product Specific Literature References

Comparative pharmacology of voltage-dependent sodium channels: W.B. Stallcup; Brain Res. 135, 37 (1977) Abstract
Purification, solubility, and pKa of veratridine: L.C. McKinney, et al.; Anal. Biochem. 153, 33 (1986) Abstract
The interaction between the activator agents batrachotoxin and veratridine and the gating processes of neuronal sodium channels: T.A. Rando, et al.; Mol. Pharmacol. 29, 467 (1986) Abstract
Rapid and slow gating of veratridine-modified sodium channels in frog myelinated nerve: T.A. Rando; J. Gen. Physiol. 93, 43 (1989) Abstract
Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine: R. Maroto, et al.; Eur. J. Pharmacol. 270, 331 (1994) Abstract
Veratridine triggers exocytosis in Paramecium cells by activating somatic Ca channels: H. Plattner, et al.; J. Membr. Biol. 142, 229 (1994) Abstract
Veratridine induces apoptotic death in bovine chromaffin cells through superoxide production: J. Jordan, et al.; Br. J. Pharmacol 130, 1496 (2000) Abstract
Alteration of veratridine neurotoxicity in sympathetic neurons during development in vitro: T. Koike and T. Ninomiya; Neuroreport 11, 151 (2000) Abstract
Excessive release of [3H] noradrenaline by veratridine and ischemia in spinal cord: Y. Sumiya, et al.; Neurochem. Int. 39, 59 (2001) Abstract
Effects of veratrine and veratridine on oxygen consumption and electrical membrane potential of isolated rat skeletal muscle and liver mitochondria: E.M. Silva Freitas, et al.; Toxicon. 47, 780 (2006) Abstract

Further Categories Containing This Product:

Ca2+ Modulators • Neurotoxins • Apoptosis Inducers & Inhibitors Other Products • Alkaloids

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