ALEXIS Biochemicals: Harpagoside

Advanced Search

You are here: Product Lines > Viral Signalling > Natural Products - Nitric Oxide Pathway Modulators

ALX-350-255

Revised 03-Apr-08

(+)-cis,trans-Abscisic acid
SYNONYMS	(S)-5-(1-Hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl)-3-methyl-[2Z,4E]-pentadienoic acid (+)-cis,trans ABA
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Plant Research Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-255-C500		500 µg	90.00 USD
ALX-350-255-M001		1 mg	160.00 USD
ALX-350-255-M005		5 mg	620.00 USD

Product Specification

FORMULA:	C₁₅H₂₀O₄
MW:	264.3
CAS NUMBER:	21293-29-8
MERCK INDEX:	14: 11
SOURCE/HOST:	Isolated from Curvularia lunata.
PURITY:	≥97%
APPEARANCE:	Off-white powder.
SOLUBILITY:	Soluble in ethanol or DMSO.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Natural and active isomer of the abscission accelerating plant hormone.

Product Specific Literature References

Metabolism and physiology of abscisic acid: J.A.D. Zeevaart & R.A. Creelman; Annu. Rev. Plant Physiol. Plant Mol. Biol. 39, 439 (1988), (Review)
Molecular responses to drought and cold stress: K. Shinozaki & K. Yamaguchi-Shinozaki; Curr. Opin. Biotechnol. 7, 161 (1996), (Review) Abstract
Abscisic acid and signal transduction: J. Leung & J. Giraudat; Annu. Rev. Plant Physiol. Plant Mol. Biol. 49, 199 (1998), (Review)
ABA signal transduction: E. Grill & A. Himmelbach; Curr. Opin. Plant Biol. 1, 412 (1998), (Review) Abstract
Signal transduction networks and the biology of plant cells: M.J. Chrispeels, et al.; Biol. Res. 32, 35 (1999), (Review) Abstract
Abscisic acid: A.M. Hetherington; Curr. Biol. 9, R390 (1999), (Review) Abstract
Regulation of abscisic acid-induced stomatal closure and anion channels by guard cell AAPK kinase: J. Li, et al.; Science 287, 300 (2000) Abstract
Mitogen-activated protein kinase and abscisic acid signal transduction: S. Heimovaara-Dijkstra, et al.; Results Probl. Cell Differ. 27, 131 (2000) Abstract
Relay and control of abscisic acid signaling: A. Himmelbach, et al.; Corr. Opin. Plant Biol. 6, 470 (2003), Review Abstract
Nitric oxide induced by hydrogen peroxide mediates abscisic acid-induced activation of the mitogen-activated protein kinase cascade involved in antioxidant defense in maize leaves: A. Zhang, et al.; New Phytol. 175, 36 (2007) Abstract
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger: S. Bruzzone, et al.; PNAS 104, 5759 (2007) Abstract

Further Categories Containing This Product:

Natural Products - Nitric Oxide Pathway Modulators • Plant Research Reagents / Related Products

ALX-350-329

Revised 21-May-08

Allicin
SYNONYMS	2-Propene-1-sulfinothioic acid S-2-propenyl ester Diallyl thiosulfinate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-329-M001		1 mg	200.00 USD
ALX-350-329-M005		5 mg	690.00 USD

Product Specification

FORMULA:	C₆H₁₀OS₂
MW:	162.3
CAS NUMBER:	539-86-6
MERCK INDEX:	14: 261
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	Clear to slightly yellow liquid.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Active metabolite of garlic. Exhibits antimicrobial, antioxidant, antiproliferative, chemopreventive, antihyperlipidaemic and antihypertensive effects. Inhibits telomerase activity. Induces apoptosis. Also inhibits inducible nitric oxide synthase (iNOS; NOS II) expression.

Product Specific Literature References

Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica: S. Ankri, et al.; Antimicrob. Agents Chemother. 41, 2286 (1997) Abstract
Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase: V.M. Dirsch, et al.; Atherosclerosis 139, 333 (1998) Abstract
Antimicrobial properties of allicin from garlic: S. Ankri & D. Mirelman; Microbes Infect. 1, 125 (1999), Review Abstract
Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation: K. Hirsch, et al.; Nutr. Cancer 38, 245 (2000) Abstract
The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats: A. Elkayam, et al.; Am. J. Hypertens. 14, 377 (2001) Abstract
Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells: L. Sun & X. Wang; World J. Gastroenterol. 9, 1930 (2003) Abstract
Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells: S. Oommen, et al.; Eur. J. Pharmacol. 485, 97 (2004) Abstract
Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus: R.R. Cutler & P. Wilson; Br. J. Biomed. Sci. 61, 71 (2004) Abstract
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin: L.J. Macpherson, et al.; Curr. Biol. 15, 929 (2005) Abstract
An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic: S.R. Davis; Mycoses 48, 95 (2005), Review Abstract
Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent: R. Hunter, et al.; Ann. N.Y. Acad. Sci. 1056, 234 (2005), Review Abstract
The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide: L.Y. Chung; J. Med. Food 9, 205 (2006) Abstract
Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial: C.D. Gardner, et al.; Arch. Intern. Med. 167, 346 (2007) Abstract

Further Categories Containing This Product:

Active Substances from Fruit and Vegetables • Antitumor Agents (Anti-proliferative) • NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Chemopreventive Agents • Natural Products with Antibiotic Activity • Natural Products - Apoptosis Inducers & Inhibitors • TRPV1 Agonists and Antagonists / Related Products

ALX-350-312

Revised 28-May-08

(-)-Arctigenin
SYNONYMS	(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-(3H)-furanone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-312-M025		25 mg	70.00 USD

Product Specification

FORMULA:	C₂₁H₂₄O₆
MW:	372.4
CAS NUMBER:	7770-78-7
SOURCE/HOST:	Isolated from Arctium lappa.
PURITY:	≥97% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (34mg/ml, heating, sonication); sparingly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Lignan derivative, which shows antitumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic protein Bcl-X_L. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic and cytotoxic properties against Hep62 cells. Antagonist for platelet activating factor and Ca²⁺. Blocks the activation of Akt (protein kinase B; PKB) induced by glucose starvation.

Product Specific Literature References

Antiproliferative effect of Arctigenin and Arctiin: S.Y. Ryu, et al.; Arch. Pharm. Res. 18, 462 (1995)
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase: E. Eich, et al.; J. Med. Chem 39, 86 (1996) Abstract
Immunomodulatory effect of arctigenin, a lignan compound, on tumour necrosis factor-alpha and nitric oxide production, and lymphocyte proliferation: J.Y. Cho, et al.; J. Pharm. Pharmacol. 51, 1267 (1999) Abstract
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor: Y.P. Jang, et al.; J. Neurosci. Res. 68, 233 (2002) 68, 233 (2002) Abstract
A phytochemical study of lignans in whole plants and cell suspension cultures of Anthriscus sylvestris: A. Koulman, et al.; Planta Med. 69, 733 (2003) Abstract
Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells: B. Hausott, et al.; J. Cancer Res. Clin. Oncol. 129, 569 (2003) Abstract
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition: M.K. Cho, et al.; Int. Immunopharmacol. 4, 1419 (2004) Abstract
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition: M.K. Cho, et al.; Int. Immunopharmacol. 4, 1419 (2004) Abstract
Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation: S. Awale, et al.; Cancer Res. 66, 1751 (2006) Abstract
The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme: K. Kang, et al.; Biol. Pharm. Bull. 30, 2352 (2007) Abstract

Further Categories Containing This Product:

Bcl-2 Family Modulators • Natural Products - Nitric Oxide Pathway Modulators • Platelet Activating Factors [PAF] & Receptors / Related Products • HIV / AIDS / Related Products • Natural Products - Topoisomerase Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products - Antiviral / anti-HIV Agents • Natural Products - Immunomodulators

ALX-350-219

Revised 28-May-08

Artemisinin
SYNONYMS	Qinghaosu
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antimalarial Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-219-M100		100 mg	35.00 USD
ALX-350-219-G001		1 g	220.00 USD

Product Specification

FORMULA:	C₁₅H₂₂O₅
MW:	282.4
CAS NUMBER:	63968-64-9
MERCK INDEX:	14: 817
SOURCE/HOST:	Isolated from the traditional Chinese anti-malarial herb Artemisia annua L.
PURITY:	≥98%
APPEARANCE:	White crystalline solid.
SOLUBILITY:	Soluble in methanol, 100% ethanol, dimethyl formamide, DMSO, chloroform or acetone; almost insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light and moisture.
HAZARD:	TOXIC.

Product Description

Powerful antimalarial agent. Inhibits angiogenesis by down-regulating HIF-1α and VEGF expression in mouse embryonic stem cells. Crosses the blood-brain barrier. Inhibitor of human iNOS (NOS II).

Product Specific Literature References

Qinghaosu (artemisinin): an antimalarial drug from China: D.L. Klayman; Science 228, 1049 (1985) Abstract
The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives: X.D. Luo & C.C. Shen; Med. Res. Rev. 7, 29 (1987) Abstract
Inhibition of angiogenesis in embryoid bodies by artemisinin: M. Wartenberg, et al.; Pflugers Arch. Eur. J. Physiol. 445, S85 (1994)
Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication: M.A. van Agtmael, et al.; Trends Pharmacol. Sci. 20, 199 (1999), Review Abstract
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation: E. Aldieri, et al.; FEBS Lett. 552, 141 (2003) Abstract
The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies: M. Wartenberg, et al.; Lab. Invest. 83, 1647 (2003) Abstract
An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb: Y. Li & Y.L. Wu; Curr. Med. Chem. 10, 2197 (2003), Review Abstract
From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements: R.K. Haynes; Curr. Top. Med. Chem. 6, 509 (2006), Review Abstract

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • Hypoxia-inducible Factor [HIF] / Related Products • Natural Products for Angiogenesis Research • Natural Products - Nitric Oxide Pathway Modulators • Malaria / Related Products

ALX-350-144

Revised 03-Apr-08

Bakuchiol
SYNONYMS	4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-144-M001		1 mg	170.00 USD

Product Specification

FORMULA:	C₁₈H₂₄O
MW:	256.4
CAS NUMBER:	10309-37-2
SOURCE/HOST:	Isolated from plant Psoralea corylifolia.
PURITY:	≥97% (HPLC)
APPEARANCE:	Yellow to brownish oil.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
IDENTITY:	Determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression. DNA polymerase inhibitor. Shows antimicrobial and cytotoxic activity.

Product Specific Literature References

Plant antimutagenic agents, 2. Flavonoids: M.E. Wall, et al.; J. Nat. Prod. 51, 1084 (1988) Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) Abstract
Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia: H. Haraguchi, et al.; Planta Med. 66, 569 (2000) Abstract
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities: C.N. Backhouse, et al.; J. Ethnopharmacol. 78, 27 (2001) Abstract
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells: H. Cho, et al.; Planta Med. 67, 750 (2001) Abstract
In vitro antimicrobial activities of bakuchiol against oral microorganisms: H. Katsura, et al.; Antimicrob. Agents Chemother. 45, 3009 (2001) Abstract; Full Text
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages: H.O. Pae, et al.; Int. Immunopharmacol. 1, 1849 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis: S.M. Newton, et al.; J. Ethnopharmacol. 79, 57 (2002) Abstract
Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain: S. Adhikari, et al.; Chem. Res. Toxicol. 16, 1062 (2003) Abstract
Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent: K. Bapat, et al.; Appl. Radiat. Isot. 62, 389 (2005) Abstract
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005) Abstract
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo: E.J. Park, et al.; Planta Med. 71, 508 (2005) Abstract
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts: E.J. Park, et al.; Eur. J. Pharmacol. 559, 115 (2007) Abstract

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - DNA Replication Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Topoisomerase Inhibitors • Natural Products with Antibiotic Activity • Protein Tyrosine Phosphatases Other Products • Lipid Peroxidation • Natural Products - Antioxidants

ALX-270-480

Revised 10-Mar-08

Caffeic acid ethyl ester
SYNONYMS	CAEE Ethyl caffeate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Anti-inflammatory Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-480-M050		50 mg	20.00 USD
ALX-270-480-M250		250 mg	60.00 USD

Product Specification

FORMULA:	C₁₁H₁₂O₄
MW:	208.2
CAS NUMBER:	66648-50-8
SOURCE/HOST:	Synthetic.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least one year after receipt when stored at -20°C.
HANDLING:	Protect from light and moisture.

Product Description

Shows anti-carcinogenic, anti-inflammatory and immunomodulatory properties. Suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production (IC₅₀=5.5µg/ml). Potent and specific inhibitor of NF-κB and its downstream inflammatory mediators inducible nitric oxide synthase (iNOS; NOS II), prostaglandin E₂ (PGE₂) and cyclooxygenase-2 (COX-2). Prevents DNA single-strand breaks caused by H₂O₂.

Product Specific Literature References

Inhibitory effects of caffeic acid ethyl ester on H2O2-induced cytotoxicity and DNA single-strand breaks in Chinese hamster V79 cells: T. Nakayama, et al.; Biosci. Biotechnol. Biochem. 60, 316 (1996) Abstract
Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin: Y.M. Chiang, et al.; Br. J. Pharmacol. 146, 352 (2005) Abstract
Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines: M. Cardenas, et al.; Bioorg. Med. Chem. 14, 2966 (2006) Abstract
Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR: K. Suzuki, et al.; Biofactors 28, 151 (2006) Abstract

Related Products

ALX-270-231	Caffeic acid
ALX-270-244	Caffeic acid phenylethyl ester

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Prostaglandins Other Products • Natural Products - Nitric Oxide Pathway Modulators • NF-kB Pathway Inhibitors • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Immunomodulators • Phenolic Acids

ALX-350-278

Revised 08-Apr-08

Caffeic acid n-octyl ester
SYNONYMS	n-Octylcaffeate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - NF-kB Pathway Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-278-M005		5 mg	25.00 USD
ALX-350-278-M025		25 mg	100.00 USD

Product Specification

FORMULA:	C₁₇H₂₄O₄
MW:	292.2
PURITY:	≥99%
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

More potent analog than CAPE (Prod. No. ALX-270-244). Suppressor of inducible nitric oxide synthase (iNOS; NOS II). Induces apoptosis.

Product Specific Literature References

Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids: B. Etzenhouser, et al.; Bioorg. Med. Chem. 9, 199 (2001) Abstract
A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells: G. Hsiao, et al.; Biochem. Pharmacol. 65, 1383 (2003) Abstract
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties: F.M. da Cunha, et al.; Free Radic. Res. 38, 1241 (2004) Abstract
Octylcaffeate induced apoptosis in human leukemia U937 cells: M. Ujibe, et al.; Biol. Pharm. Bull. 28, 2338 (2005) Abstract

General Information

Octylcaffeate significantly ameliorates circulatory failure of endotoxemia by suppression of iNOS (NOS II) expression through inactivation of mitogen-activated protein kinases.

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Immunomodulators • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Anti-inflammatory Agents • NF-kB Pathway Inhibitors • Natural Products - Antioxidants • Natural Products - Apoptosis Inducers & Inhibitors • Phenolic Acids

ALX-350-015

Revised 15-Sep-08

(S)-(+)-Camptothecin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Topoisomerase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-015-M050		50 mg	40.00 USD
ALX-350-015-M250		250 mg	150.00 USD
ALX-350-015-G001		1 g	295.00 USD

Product Specification

FORMULA:	C₂₀H₁₆N₂O₄
MW:	348.4
CAS NUMBER:	7689-03-4
MERCK INDEX:	14: 1735
RTECS:	UQ0492000
SOURCE/HOST:	Isolated from Mappia foetida Miers (Nothapodytes foetida (Wt.) Sleumer).
PURITY:	≥98% (HPLC)
APPEARANCE:	Pale yellow powder.
SOLUBILITY:	Soluble in DMSO (10mg/ml), methanol (40mg/ml) or 0.1N sodium hydroxide (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and moisture. After reconstitution, prepare aliquots and store at -20°C.
HAZARD:	TOXIC.

Product Description

Potent antitumor agent. Inhibitor of DNA-topoisomerase I. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cells. Suppresses nitric oxide (NO) biosynthesis.

Product Specific Literature References

M.E. Wall, et al.; JACS 88, 3888 (1966)
The current status of camptothecin analogues as antitumor agents: W.J. Slichenmyer, et al.; J. Natl. Cancer Inst. 85, 271 (1993), (Review) Abstract
RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells: J.L. Janavs, et al.; Mol. Brain Res. 23, 47 (1994) Abstract
Camptothecins: from bench research to hospital wards: M. Potmesil; Cancer Res. 54, 1431 (1994), (Review) Abstract
Forskolin and camptothecin induce a 30 kDa protein associated with melatonin production in Y79 human retinoblastoma cells: J.L. Janavs, et al.; J. Neurosci. 15, 298 (1995) Abstract
Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives: A. Tanizawa, et al.; Biochemistry 34, 7200 (1995) Abstract
The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription: M. Ljungman & P.C. Hanawalt; Carcinogenesis 17, 31 (1996) Abstract
The cell cycle effects of camptothecin: Z. Darzynkiewicz, et al.; Ann. N. Y. Acad. Sci. 803, 93 (1996) Abstract
Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases: T. Shimizu & Y. Pommier; Leukemia 11, 1238 (1997)