• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Natural Products - Immunomodulators
You are here: Product Lines > Natural Products / Antibiotics > Natural Products > Natural Products - Immunomodulators
Toolbar - View Selection
 
 Items 20-34 of 34 Page 2 of 2 Select Page: << 1 2   
ALX-350-274 Revised 16-Jun-08
Myriocin
Add to Clipboard
SYNONYMS ISP-1
Thermozymocidin
2S,3R,4R,6E-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxo-6-eicosenoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Immunomodulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-274-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C21H39NO6
MW: 401.5
CAS NUMBER: 35891-70-4
RTECS: JX3890000
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (25mg/ml; heat briefly in boiling water bath) or in dilute base (5mg/ml; 50mM NaOH).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Potent immunosuppressant ~10 to 100-fold more potent than cyclosporin A (Prod. No. ALX-380-002). Blocks sphingolipid biosynthesis by inhibiting serine palmitoyltransferase (Ki=0.28nM). Induces apoptosis by depletion of cellular sphingolipids. Inhibits proliferation of an IL-2-dependent mouse cytotoxic cell line CTLL-1 (IC50=15nM).
Product Specific Literature References
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite: T. Fujita, et al.; J. Antibiot. 47, 208 (1994) Abstract
Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin: Y. Miyake, et al.; BBRC 211, 396 (1995) Abstract
Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells: S. Furuya, et al.; J. Neurochem. 71, 366 (1998) Abstract
Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells: K. Hidari, et al.; J. Biol. Chem. 271, 14636 (1996) Abstract
Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast: Y. Sun, et al.; Mol. Cell. Biol. 20, 4411 (2000) Abstract; Full Text
Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice: M.R. Hojjati, et al.; J. Biol. Chem. 280, 10284 (2005) Abstract
Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model: T. Umehara, et al.; BBRC 346, 67 (2006) Abstract
Related Products
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Sphingolipids & Glycosphingolipids Other Products • Natural Products - Antiviral/anti-HIV Agents
 
 
ALX-350-228 Revised 08-Jul-08
Nomilin
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-228-M025   25 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C28H34O9
MW: 514.6
CAS NUMBER: 1063-77-0
MERCK INDEX: 14: 6674
SOURCE/HOST: Isolated from grapefruit seed and citrus juice.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone; slightly soluble in 100% ethanol, methanol, isopropanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Induces phase II detoxifying enzymes and inhibits chemically induced carcinogenesis. Exhibits immunomodulatory activity and also inhibits HIV-1 replication. Does not possess any inherent antioxidant capacity.
Product Specific Literature References
V.P. Maier, et al.; ACS Symposium Series 143, 63 (1980)
Inhibition of benzo[a]pyrene-induced forestomach neoplasia in mice by citrus limonoids: L.K.T. Lam & S. Hasegawa; Nutr. Cancer 12, 43 (1989) Abstract
The effect of citrus limonoids on hamster buccal pouch carcinogenesis: E.G. Miller, et al.; Carcinogenesis 10, 1535 (1989) Abstract
Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system: T.J. Raphael & G. Kuttan; Phytomedicine 10, 483 (2003) Abstract
Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells: L. Battinelli, et al.; Planta Med. 69, 910 (2003) Abstract
Evaluation of the antioxidant capacity of limonin, nomilin, and limonin glucoside: A.P. Breksa, 3rd & G.D. Manners; J. Agric. Food Chem. 54, 3827 (2006) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Natural Products - Antiviral/anti-HIV Agents • Natural Products - Immunomodulators • Active Substances from Fruit and Vegetables
 
 
ALX-350-285 Revised 19-Feb-08
Proscillaridin A
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-285-M005   5 mg 17.00 USD Add To Cart
Product Specification
FORMULA: C30H42O8
MW: 530.7
CAS NUMBER: 466-06-8
RTECS: UK6650000
PURITY: ≥90%
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.
IDENTITY: Determined by IR.

Product Description
Cardiac glycoside. Specific Na+/K+-ATPase inhibitor. Shows high cytotoxicity in tumor cells. Very potent immunosuppressor. DNA topoisomerase I & II inhibitor.
Product Specific Literature References
Clinical studies on proscillaridin a new squill glycoside: L. Gould, et al.; J. Clin. Pharmacol. New Drugs 11, 135 (1971) Abstract
Proscillaridin A immunoreactivity: a new endogenous cardiac glycoside?: S.Q. Li, et al.; Ann. N Y Acad. Sci. 834, 646 (1997) Abstract
Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells: S. Johansson, et al.; Anticancer Drugs 12, 475 (2001) Abstract
Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A: K. Bielawski, et al.; Biol. Pharm. Bull. 29, 1493 (2006) Abstract
Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells: K. Winnicka, et al.; Arch. Pharm. Res. 30, 1216 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Topoisomerase Inhibitors • Na+/K+-ATPase/Related Products • Natural Products - Immunomodulators
 
 
ALX-350-286 Revised 31-May-07
Resibufogenin
Add to Clipboard
SYNONYMS (3β,5β,15β)-14,15-Epoxy-3-hydroxy-5-bufa-20,22-dienolide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-286-M010   10 mg 300.00 USD Add To Cart
Product Specification
FORMULA: C24H32O4
MW: 384.5
CAS NUMBER: 465-39-4
MERCK INDEX: 14: 8146
RTECS: EI2975000
SOURCE/HOST: Isolated from Bufonis venom.
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in chloroform.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Specific Na+/K+-ATPase inhibitor.
Product Specific Literature References
Effects of resibufogenin from toad venom on isolated Purkinje fibers: J.T. Xie, et al.; Am. J. Chin. Med. 28, 187 (2000) Abstract
Resibufogenin corrects hypertension in a rat model of human preeclampsia: H. Vu, et al.; Exp. Biol. Med. (Maywood) 231, 215 (2006) Abstract
Further Categories Containing This Product:
Na+/K+-ATPase/Related Products • Natural Products - Immunomodulators
 
 
ALX-350-121 Revised 14-Mar-08
Rocaglamide
Add to Clipboard
SYNONYMS Rocaglamide A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-121-C100   100 µg 220.00 USD Add To Cart
Product Specification
FORMULA: C29H31NO7
MW: 505.6
CAS NUMBER: 84573-16-0
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Immunosuppressant. Potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-κB and AP-1 activities. In contrast to the immunosuppressant cyclosporin A (Prod. No. ALX-380-002), rocaglamide does not inhibit calcineurin phosphatase activity. Induces apoptosis.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000)
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000)
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001)
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006)
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006)
The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities: J.Y. Zhu, et al.; Int. J. Cancer 121, 1839 (2007) Abstract
Related Products
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • NF-kB Pathway Inhibitors • Nuclear Factor of Activated T Cells [NF-AT] • Other Natural Products - DNA Regulation/Transcription • Natural Products - Chemopreventive Agents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Immunomodulators
 
 
ALX-350-140 Revised 22-Aug-07
Rocaglamide AL 
Add to Clipboard
SYNONYMS 3’-4’-Methylenedioxyrocaglamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-140-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C26H24O7
MW: 448.5
CAS NUMBER: 201212-33-1
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000)
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000) Abstract
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001)
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006)
Related Products
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • NF-kB Pathway Inhibitors • Other Natural Products - DNA Regulation/Transcription • Nuclear Factor of Activated T Cells [NF-AT] • Natural Products - Immunomodulators
 
 
ALX-350-141 Revised 22-Aug-07
Rocaglamide C
Add to Clipboard
SYNONYMS 3’-Hydroxyrocaglamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-141-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C29H31NO8
MW: 521.6
CAS NUMBER: 189322-67-6
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000)
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000)
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001)
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006)
Related Products
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • NF-kB Pathway Inhibitors • Other Natural Products - DNA Regulation/Transcription • Nuclear Factor of Activated T Cells [NF-AT] • Natural Products - Immunomodulators
 
 
ALX-350-142 Revised 22-Aug-07
Rocaglamide I
Add to Clipboard
SYNONYMS 1-Acetyl-3’-hydroxyrocaglamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-142-C050   50 µg 160.00 USD Add To Cart
Product Specification
FORMULA: C31H33NO9
MW: 563.6
CAS NUMBER: 189322-68-7
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS, 1H-NMR.

Product Description
Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000)
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000)
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001)
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006) Abstract
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006)
Related Products
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • NF-kB Pathway Inhibitors • Other Natural Products - DNA Regulation/Transcription • Nuclear Factor of Activated T Cells [NF-AT] • Natural Products - Immunomodulators
 
 
ALX-350-143 Revised 22-Aug-07
Rocaglamide J
Add to Clipboard
SYNONYMS Aglafolin
2-Methylrocaglate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-143-C050   50 µg 160.00 USD